Antibodies against aquaporin-4 in neuromyelitis optica: distinction between recurrent and monophasic patients

Immy Ketelslegers, PW Modderman, A Vennegoor, J Killestein, D (Dörte) Hamann, Rogier Hintzen

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The detection of antibodies against aquaporin-4 (AQP4) has improved the diagnosis of neuromyelitis optica (NMO). We evaluated a recently established cell-based anti-AQP4 assay in 273 patients with inflammatory CNS demyelination. The assay had a specificity of 99% and a sensitivity of 56% to detect all NMO patients and of 74% to detect the recurrent NMO patients, similar to the initial studies reported. AQP4 antibodies were absent in monophasic NMO patients, while samples in recurrent cases remained positive during follow-up. We conclude that the pathogenesis of monophasic NMO may be different from that of relapsing NMO.
Original languageUndefined/Unknown
Pages (from-to)1527-1530
Number of pages4
JournalMultiple Sclerosis
Issue number12
Publication statusPublished - 2011

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