Antidepressants with a high serotonin reuptake transporter affinity and serum lipid levels in a population-based study in older adults

Raymond Noordam, Nikkie Aarts, Toke de Keyser, Bert Hofman, Bruno Stricker, Loes Visser

Research output: Contribution to journalArticleAcademicpeer-review

6 Citations (Scopus)

Abstract

Objective: We aimed to investigate the association between antidepressants and serum lipid levels in a population-based study in older adults. Methods: We included participants from the prospective Rotterdam Study with data on lipid levels (total, low-density lipoprotein (LDL) and high-density lipoprotein cholesterol, and triglycerides). We classified antidepressants based on binding affinity to the serotonin transporter (low/intermediate- and high-affinity antidepressants). We compared lipid levels in users of these groups of antidepressants with lipid levels in non-users. Furthermore, we studied effect modification by the 102C>T polymorphism (HTR2A gene), which is associated with antidepressant drug response and metabolic outcomes. Results: Compared with non-users (N = 6438), LDL cholesterol level was higher (2.9 versus 3.1 mmol/L, respectively; p = 0.05) in users of high-affinity antidepressants (N = 89). Similar levels of the other lipids were observed between the groups for the other lipids. The mean difference in serum LDL cholesterol level between non-users and users of high-affinity antidepressants was largest in participants with the CC genotype compared with the other genotypes (notably 0.47 mmol/L), indicative of effect modification (p-value for interaction = 0.03). Conclusion: Antidepressants with a high serotonin reuptake transporter affinity were associated with higher LDL cholesterol levels, which were modified by a common genetic variation in the HTR2A gene.
Original languageUndefined/Unknown
Pages (from-to)1112-1118
Number of pages7
JournalJournal of Psychopharmacology
Volume29
Issue number10
DOIs
Publication statusPublished - 2015

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