Antifungal Activity of Natural Naphthoquinones and Anthraquinones Against Madurella mycetomatis

MA Jingyi; Matthew Todd; Wendy van de Sande; Bernhard Biersack

doi:10.1002/cbdv.202300151

Antifungal Activity of Natural Naphthoquinones and Anthraquinones Against Madurella mycetomatis

MA Jingyi
, Matthew Todd
, Wendy van de Sande^*
, Bernhard Biersack^*

^*Corresponding author for this work

Medical Microbiology & Infectious Diseases

University of Bayreuth
University College London

Research output: Contribution to journal › Article › Academic › peer-review

14 Citations (Scopus)

42 Downloads (Pure)

Abstract

Eumycetoma, the fungal form of the neglected tropical disease mycetoma, is a crippling infectious disease with low response rates to currently available antifungal drugs. In this study, a series of natural naphthoquinones and anthraquinones was evaluated for their activity against Madurella mycetomatis, which is the most common causative agent of eumycetoma. The metabolic activity of Madurella mycetomatis as well as the viability of Galleria mellonella larvae upon treatment with quinones was investigated. Several hydroxy-substituted naphthoquinones exhibited activity against Madurella mycetomatis. In particular, naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) was identified as a considerably active antifungal compound against Madurella mycetomatis (IC50 = 1.4 µM), while it showed reduced toxicity to Galleria mellonella larvae, which is a well-established in vivo invertebrate model for mycetoma drug studies.

Original language	English
Article number	e202300151
Journal	Chemistry and Biodiversity
Volume	20
Issue number	5
Early online date	17 Apr 2023
DOIs	https://doi.org/10.1002/cbdv.202300151
Publication status	Published - May 2023

Bibliographical note

Funding Information:
The authors thank Antony Sama and all those contributors to MycetOS not named as authors for their help with this research. We are grateful to Prof. Ahmed Fahal of the Mycetoma Research Center in Sudan for providing the M. mycetomatis strains MM49 and MM55, Prof. Dipak Thampke and Jagdish Chander for providing strains I1, I3 and I11, and Prof. Beatriz Bustamante for providing strain Peru72012 used for the in vitro antifungal susceptibility testing. Open Access funding enabled and organized by Projekt DEAL.

Publisher Copyright:
© 2023 The Authors. Chemistry & Biodiversity published by Wiley-VHCA AG, Zurich, Switzerland.

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SDG 3 Good Health and Well-being

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Antifungal Activity of Natural Naphthoquinones and Anthraquinones Against Madurella mycetomatisFinal published version, 647 KBLicence: CC BY-NC

Cite this

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title = "Antifungal Activity of Natural Naphthoquinones and Anthraquinones Against Madurella mycetomatis",

abstract = "Eumycetoma, the fungal form of the neglected tropical disease mycetoma, is a crippling infectious disease with low response rates to currently available antifungal drugs. In this study, a series of natural naphthoquinones and anthraquinones was evaluated for their activity against Madurella mycetomatis, which is the most common causative agent of eumycetoma. The metabolic activity of Madurella mycetomatis as well as the viability of Galleria mellonella larvae upon treatment with quinones was investigated. Several hydroxy-substituted naphthoquinones exhibited activity against Madurella mycetomatis. In particular, naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) was identified as a considerably active antifungal compound against Madurella mycetomatis (IC50 = 1.4 µM), while it showed reduced toxicity to Galleria mellonella larvae, which is a well-established in vivo invertebrate model for mycetoma drug studies.",

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N1 - Funding Information: The authors thank Antony Sama and all those contributors to MycetOS not named as authors for their help with this research. We are grateful to Prof. Ahmed Fahal of the Mycetoma Research Center in Sudan for providing the M. mycetomatis strains MM49 and MM55, Prof. Dipak Thampke and Jagdish Chander for providing strains I1, I3 and I11, and Prof. Beatriz Bustamante for providing strain Peru72012 used for the in vitro antifungal susceptibility testing. Open Access funding enabled and organized by Projekt DEAL. Publisher Copyright: © 2023 The Authors. Chemistry & Biodiversity published by Wiley-VHCA AG, Zurich, Switzerland.

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N2 - Eumycetoma, the fungal form of the neglected tropical disease mycetoma, is a crippling infectious disease with low response rates to currently available antifungal drugs. In this study, a series of natural naphthoquinones and anthraquinones was evaluated for their activity against Madurella mycetomatis, which is the most common causative agent of eumycetoma. The metabolic activity of Madurella mycetomatis as well as the viability of Galleria mellonella larvae upon treatment with quinones was investigated. Several hydroxy-substituted naphthoquinones exhibited activity against Madurella mycetomatis. In particular, naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) was identified as a considerably active antifungal compound against Madurella mycetomatis (IC50 = 1.4 µM), while it showed reduced toxicity to Galleria mellonella larvae, which is a well-established in vivo invertebrate model for mycetoma drug studies.

AB - Eumycetoma, the fungal form of the neglected tropical disease mycetoma, is a crippling infectious disease with low response rates to currently available antifungal drugs. In this study, a series of natural naphthoquinones and anthraquinones was evaluated for their activity against Madurella mycetomatis, which is the most common causative agent of eumycetoma. The metabolic activity of Madurella mycetomatis as well as the viability of Galleria mellonella larvae upon treatment with quinones was investigated. Several hydroxy-substituted naphthoquinones exhibited activity against Madurella mycetomatis. In particular, naphthazarin (5,8-dihydroxy-1,4-naphthoquinone) was identified as a considerably active antifungal compound against Madurella mycetomatis (IC50 = 1.4 µM), while it showed reduced toxicity to Galleria mellonella larvae, which is a well-established in vivo invertebrate model for mycetoma drug studies.

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Antifungal Activity of Natural Naphthoquinones and Anthraquinones Against Madurella mycetomatis

Abstract

Bibliographical note

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