Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

RJ Garten; CT Davis; CA Russell; B Shu; S Lindstrom; A Balish; WM Sessions; XY Xu; E Skepner; V Deyde; M Okomo-Adhiambo; L Gubareva; J Barnes; CB Smith; SL Emery; MJ Hillman; P Rivailler; J Smagala; Miranda de Graaf; DF Burke; Ron Fouchier; C Pappas; CM Alpuche-Aranda; H Lopez-Gatell; H Olivera; I Lopez; CA Myers; D Faix; PJ Blair; C Yu; KM Keene; PD Dotson; D Boxrud; AR Sambol; SH Abid; KS George; T Bannerman; AL Moore; DJ Stringer; P Blevins; GJ Demmler-Harrison; M Ginsberg; P Kriner; S Waterman; S Smole; HF Guevara; EA Belongia; PA Clark; ST Beatrice; R Donis; J Katz; L Finelli; CB Bridges; M Shaw; DB Jernigan; TM Uyeki; Derek Smith; AI Klimov; NJ Cox

doi:10.1126/science.1176225

Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

RJ Garten
, CT Davis
, CA Russell
, B Shu
, S Lindstrom
, A Balish
, WM Sessions
, XY Xu
, E Skepner
, V Deyde
, M Okomo-Adhiambo
, L Gubareva
, J Barnes
, CB Smith
, SL Emery
, MJ Hillman
, P Rivailler
, J Smagala
, Miranda de Graaf
, DF Burke

Ron Fouchier, C Pappas, CM Alpuche-Aranda, H Lopez-Gatell, H Olivera, I Lopez, CA Myers, D Faix, PJ Blair, C Yu, KM Keene, PD Dotson, D Boxrud, AR Sambol, SH Abid, KS George, T Bannerman, AL Moore, DJ Stringer, P Blevins, GJ Demmler-Harrison, M Ginsberg, P Kriner, S Waterman, S Smole, HF Guevara, EA Belongia, PA Clark, ST Beatrice, R Donis, J Katz, L Finelli, CB Bridges, M Shaw, DB Jernigan, TM Uyeki, Derek Smith, AI Klimov, NJ Cox

Virology

Research output: Contribution to journal › Article › Academic › peer-review

2205 Citations (Scopus)

Abstract

Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).

Original language	Undefined/Unknown
Pages (from-to)	197-201
Number of pages	5
Journal	Science
Volume	325
Issue number	5937
DOIs	https://doi.org/10.1126/science.1176225
Publication status	Published - 2009

Research programs

EMC MM-04-27-01

Access to Document

10.1126/science.1176225

http://hdl.handle.net/1765/25228

Cite this

Garten, RJ., Davis, CT., Russell, CA., Shu, B., Lindstrom, S., Balish, A., Sessions, WM., Xu, XY., Skepner, E., Deyde, V., Okomo-Adhiambo, M., Gubareva, L., Barnes, J., Smith, CB., Emery, SL., Hillman, MJ., Rivailler, P., Smagala, J., de Graaf, M., ... Cox, NJ. (2009). Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans. Science, 325(5937), 197-201. https://doi.org/10.1126/science.1176225

@article{709888ce1ff44e25a2b5ecc58adc39bc,

title = "Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans",

abstract = "Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).",

author = "RJ Garten and CT Davis and CA Russell and B Shu and S Lindstrom and A Balish and WM Sessions and XY Xu and E Skepner and V Deyde and M Okomo-Adhiambo and L Gubareva and J Barnes and CB Smith and SL Emery and MJ Hillman and P Rivailler and J Smagala and \{de Graaf\}, Miranda and DF Burke and Ron Fouchier and C Pappas and CM Alpuche-Aranda and H Lopez-Gatell and H Olivera and I Lopez and CA Myers and D Faix and PJ Blair and C Yu and KM Keene and PD Dotson and D Boxrud and AR Sambol and SH Abid and KS George and T Bannerman and AL Moore and DJ Stringer and P Blevins and GJ Demmler-Harrison and M Ginsberg and P Kriner and S Waterman and S Smole and HF Guevara and EA Belongia and PA Clark and ST Beatrice and R Donis and J Katz and L Finelli and CB Bridges and M Shaw and DB Jernigan and TM Uyeki and Derek Smith and AI Klimov and NJ Cox",

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doi = "10.1126/science.1176225",

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Garten, RJ, Davis, CT, Russell, CA, Shu, B, Lindstrom, S, Balish, A, Sessions, WM, Xu, XY, Skepner, E, Deyde, V, Okomo-Adhiambo, M, Gubareva, L, Barnes, J, Smith, CB, Emery, SL, Hillman, MJ, Rivailler, P, Smagala, J, de Graaf, M, Burke, DF, Fouchier, R, Pappas, C, Alpuche-Aranda, CM, Lopez-Gatell, H, Olivera, H, Lopez, I, Myers, CA, Faix, D, Blair, PJ, Yu, C, Keene, KM, Dotson, PD, Boxrud, D, Sambol, AR, Abid, SH, George, KS, Bannerman, T, Moore, AL, Stringer, DJ, Blevins, P, Demmler-Harrison, GJ, Ginsberg, M, Kriner, P, Waterman, S, Smole, S, Guevara, HF, Belongia, EA, Clark, PA, Beatrice, ST, Donis, R, Katz, J, Finelli, L, Bridges, CB, Shaw, M, Jernigan, DB, Uyeki, TM, Smith, D, Klimov, AI & Cox, NJ 2009, 'Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans', Science, vol. 325, no. 5937, pp. 197-201. https://doi.org/10.1126/science.1176225

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T1 - Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

AU - Garten, RJ

AU - Davis, CT

AU - Russell, CA

AU - Shu, B

AU - Lindstrom, S

AU - Balish, A

AU - Sessions, WM

AU - Xu, XY

AU - Skepner, E

AU - Deyde, V

AU - Okomo-Adhiambo, M

AU - Gubareva, L

AU - Barnes, J

AU - Smith, CB

AU - Emery, SL

AU - Hillman, MJ

AU - Rivailler, P

AU - Smagala, J

AU - de Graaf, Miranda

AU - Burke, DF

AU - Fouchier, Ron

AU - Pappas, C

AU - Alpuche-Aranda, CM

AU - Lopez-Gatell, H

AU - Olivera, H

AU - Lopez, I

AU - Myers, CA

AU - Faix, D

AU - Blair, PJ

AU - Yu, C

AU - Keene, KM

AU - Dotson, PD

AU - Boxrud, D

AU - Sambol, AR

AU - Abid, SH

AU - George, KS

AU - Bannerman, T

AU - Moore, AL

AU - Stringer, DJ

AU - Blevins, P

AU - Demmler-Harrison, GJ

AU - Ginsberg, M

AU - Kriner, P

AU - Waterman, S

AU - Smole, S

AU - Guevara, HF

AU - Belongia, EA

AU - Clark, PA

AU - Beatrice, ST

AU - Donis, R

AU - Katz, J

AU - Finelli, L

AU - Bridges, CB

AU - Shaw, M

AU - Jernigan, DB

AU - Uyeki, TM

AU - Smith, Derek

AU - Klimov, AI

AU - Cox, NJ

PY - 2009

Y1 - 2009

N2 - Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).

AB - Since its identification in April 2009, an A(H1N1) virus containing a unique combination of gene segments from both North American and Eurasian swine lineages has continued to circulate in humans. The lack of similarity between the 2009 A(H1N1) virus and its nearest relatives indicates that its gene segments have been circulating undetected for an extended period. Its low genetic diversity suggests that the introduction into humans was a single event or multiple events of similar viruses. Molecular markers predictive of adaptation to humans are not currently present in 2009 A(H1N1) viruses, suggesting that previously unrecognized molecular determinants could be responsible for the transmission among humans. Antigenically the viruses are homogeneous and similar to North American swine A(H1N1) viruses but distinct from seasonal human A(H1N1).

U2 - 10.1126/science.1176225

DO - 10.1126/science.1176225

M3 - Article

C2 - 19465683

SN - 0036-8075

VL - 325

SP - 197

EP - 201

JO - Science

JF - Science

IS - 5937

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