Antimüllerian hormone serum levels: a putative marker for ovarian aging

Annemarie de Vet; Joop S.E. Laven; Frank H. de Jong; Axel P.N. Themmen; Bart C.J.M. Fauser

doi:10.1016/S0015-0282(01)02993-4

Antimüllerian hormone serum levels: a putative marker for ovarian aging

Annemarie de Vet
, Joop S.E. Laven
, Frank H. de Jong
, Axel P.N. Themmen
, Bart C.J.M. Fauser

Research output: Contribution to journal › Article › Academic › peer-review

802 Citations (Scopus)

4 Downloads (Pure)

Abstract

Objective: To investigate whether serum concentrations of antimüllerian hormone may be used as a marker for ovarian aging.
Design: Longitudinal observational study.
Setting: Academic research center.
Patient(s): Forty-one normo-ovulatory premenopausal women and 13 healthy postmenopausal women.
Main Outcome Measure(s): Concentrations of serum antimüllerian hormone, FSH, inhibin B, and estradiol and number of ovarian follicles on ultrasonography.
Result(s): Concentrations of antimüllerian hormone decreased significantly over time whereas the number of antral follicles and levels of FSH and inhibin B did not change. During visits 1 and 2, concentrations of antimüllerian hormone correlated with age; number of antral follicles; and, to a lesser extent, with FSH level but not with inhibin B levels.
Conclusion(s): Serum concentrations of antimüllerian hormone decreased over time in young normo-ovulatory women, whereas other markers associated with ovarian aging did not change. Concentrations of antimüllerian hormone correlate with the number of antral follicles and age and less strongly with FSH level. Concentrations of antimüllerian hormone may be a novel marker for ovarian aging.

Original language	English
Pages (from-to)	357-362
Number of pages	6
Journal	Fertility & Sterility
Volume	77
Issue number	2
DOIs	https://doi.org/10.1016/S0015-0282(01)02993-4
Publication status	Published - Feb 2002

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EMC 02-01-38-01-01
EMC 02-01-82-01-02
EMC 02-01-82-01-04
EMC MM-01-52-07

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10.1016/S0015-0282(01)02993-4

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http://hdl.handle.net/1765/62052

802 Citations
1 Article

Antimüllerian hormone serum levels: a putative marker for ovarian aging [Reprint]
de Vet, A., Laven, J. S. E., de Jong, F. H., Themmen, A. P. N. & Fauser, B. C. J. M., Oct 2019, In: Fertility & Sterility. 112, 4 S1, p. E183-E188
Research output: Contribution to journal › Article › Academic › peer-review

8 Citations (Scopus)

Cite this

@article{b169fc4b6e4f4503be81defe15cc59eb,

title = "Antim{\"u}llerian hormone serum levels: a putative marker for ovarian aging",

abstract = "Objective: To investigate whether serum concentrations of antim{\"u}llerian hormone may be used as a marker for ovarian aging. Design: Longitudinal observational study. Setting: Academic research center. Patient(s): Forty-one normo-ovulatory premenopausal women and 13 healthy postmenopausal women. Main Outcome Measure(s): Concentrations of serum antim{\"u}llerian hormone, FSH, inhibin B, and estradiol and number of ovarian follicles on ultrasonography. Result(s): Concentrations of antim{\"u}llerian hormone decreased significantly over time whereas the number of antral follicles and levels of FSH and inhibin B did not change. During visits 1 and 2, concentrations of antim{\"u}llerian hormone correlated with age; number of antral follicles; and, to a lesser extent, with FSH level but not with inhibin B levels. Conclusion(s): Serum concentrations of antim{\"u}llerian hormone decreased over time in young normo-ovulatory women, whereas other markers associated with ovarian aging did not change. Concentrations of antim{\"u}llerian hormone correlate with the number of antral follicles and age and less strongly with FSH level. Concentrations of antim{\"u}llerian hormone may be a novel marker for ovarian aging.",

author = "\{de Vet\}, Annemarie and Laven, \{Joop S.E.\} and \{de Jong\}, \{Frank H.\} and Themmen, \{Axel P.N.\} and Fauser, \{Bart C.J.M.\}",

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year = "2002",

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doi = "10.1016/S0015-0282(01)02993-4",

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volume = "77",

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T2 - a putative marker for ovarian aging

AU - de Vet, Annemarie

AU - Laven, Joop S.E.

AU - de Jong, Frank H.

AU - Themmen, Axel P.N.

AU - Fauser, Bart C.J.M.

PY - 2002/2

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N2 - Objective: To investigate whether serum concentrations of antimüllerian hormone may be used as a marker for ovarian aging. Design: Longitudinal observational study. Setting: Academic research center. Patient(s): Forty-one normo-ovulatory premenopausal women and 13 healthy postmenopausal women. Main Outcome Measure(s): Concentrations of serum antimüllerian hormone, FSH, inhibin B, and estradiol and number of ovarian follicles on ultrasonography. Result(s): Concentrations of antimüllerian hormone decreased significantly over time whereas the number of antral follicles and levels of FSH and inhibin B did not change. During visits 1 and 2, concentrations of antimüllerian hormone correlated with age; number of antral follicles; and, to a lesser extent, with FSH level but not with inhibin B levels. Conclusion(s): Serum concentrations of antimüllerian hormone decreased over time in young normo-ovulatory women, whereas other markers associated with ovarian aging did not change. Concentrations of antimüllerian hormone correlate with the number of antral follicles and age and less strongly with FSH level. Concentrations of antimüllerian hormone may be a novel marker for ovarian aging.

AB - Objective: To investigate whether serum concentrations of antimüllerian hormone may be used as a marker for ovarian aging. Design: Longitudinal observational study. Setting: Academic research center. Patient(s): Forty-one normo-ovulatory premenopausal women and 13 healthy postmenopausal women. Main Outcome Measure(s): Concentrations of serum antimüllerian hormone, FSH, inhibin B, and estradiol and number of ovarian follicles on ultrasonography. Result(s): Concentrations of antimüllerian hormone decreased significantly over time whereas the number of antral follicles and levels of FSH and inhibin B did not change. During visits 1 and 2, concentrations of antimüllerian hormone correlated with age; number of antral follicles; and, to a lesser extent, with FSH level but not with inhibin B levels. Conclusion(s): Serum concentrations of antimüllerian hormone decreased over time in young normo-ovulatory women, whereas other markers associated with ovarian aging did not change. Concentrations of antimüllerian hormone correlate with the number of antral follicles and age and less strongly with FSH level. Concentrations of antimüllerian hormone may be a novel marker for ovarian aging.

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EP - 362

JO - Fertility & Sterility

JF - Fertility & Sterility

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Antimüllerian hormone serum levels: a putative marker for ovarian aging

Abstract

Bibliographical note

Research programs

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Research output

Antimüllerian hormone serum levels: a putative marker for ovarian aging [Reprint]

Cite this