Aorta pathology and pregnancy

Research output: Contribution to journalArticleAcademicpeer-review

38 Citations (Scopus)


In addition to the haemodynamic changes in pregnancy, hormones also induce changes in the aortic wall. Women with diseases like Marfan syndrome, Ehlers-Danlo syndrome, or other aortic abnormalities, have an increased risk of complications during pregnancy. Counselling and risk assessment before pregnancy is mandatory for all women with known aortic disease. Proper information should be provided about the risks of morbidity and mortality during pregnancy and information on the risks for the fetus, including the potential recurrence of disease in the offspring. Evaluation of past medical and family history, the aortic size before conception, and any increase in size before and during pregnancy, is essential to try and estimate the risk of aortic dissection. If the aorta is dilated, prophylactic repair before pregnancy may be indicated. In some cases, elective surgery during pregnancy may be warranted. In women with a severely dilated ascending aorta, caesarean section is, at present, the advised mode of delivery. (C) 2014 Elsevier Ltd. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)537-550
Number of pages14
JournalBest Practice & Research in Clinical Obstetrics & Gynaecology
Issue number4
Publication statusPublished - 2014

Cite this