APC, signal transduction and genetic instability in colorectal cancer

Riccardo Fodde*, Ron Smits, Hans Clevers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

759 Citations (Scopus)
15 Downloads (Pure)


Colorectal cancer arises through a gradual series of histological changes, each of which is accompanied by a specific genetic alteration. In general, an intestinal cell needs to comply with two essential requirements to develop into a cancer: it must acquire selective advantage to allow for the initial clonal expansion, and genetic instability to allow for multiple hits in other genes that are responsible for tumour progression and malignant transformation. Inactivation of APC - the gene responsible for most cases of colorectal cancer - might fulfil both requirements.

Original languageEnglish
Pages (from-to)55-67
Number of pages13
JournalNature Reviews Cancer
Issue number1
Publication statusPublished - 1 Oct 2001
Externally publishedYes


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