Application of single-vial ready-for-use formulation of In-111- or Lu-177-labelled somatostatin analogs

Erik de Blois, Ho Sze Chan, R de Zanger, Mark Konijnenberg, Wout Breeman

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)

Abstract

For the sake of safety it would be desirable to store and transport the ready-for-use liquid formulation (diagnostics and therapeutics) of radiolabelled peptides. The use of ethanol, in combination with a mixture of gentisic- and ascorbic acid, has superior effects on stabilizing radiolabelled somatostatin analogs. As a consequence, In-111- and Lu-177-labelled somatostatin analogs can be stored and transported in a single-vial ready-for-use liquid formulation up to 7 days after radiolabelling. (C) 2013 Elsevier Ltd. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)28-33
Number of pages6
JournalApplied Radiation & Isotopes
Volume85
DOIs
Publication statusPublished - 2014

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