Arterial Stiffness and Cerebral Small Vessel Disease The Rotterdam Scan Study

Marielle Poels, Keren Zaccai, Germaine Verwoert, Meike Vernooij, Bert Hofman, Aad van der Lugt, JCM Witteman, Monique Breteler, F.U.S. Mattace Raso, Arfan Ikram

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Abstract

Background and Purpose-Aging and vascular risk factors contribute to arterial stiffening. Increased arterial stiffness exposes the small vessels in the brain to abnormal flow pulsations and, as such, may contribute to the pathogenesis of cerebral small vessel disease. In a population-based study, we investigated the association between arterial stiffness, as measured by aortic pulse wave velocity (aPWV), and small vessel disease. Methods-Overall, 1460 participants (mean age, 58.2 years) underwent aPWV measurement and brain MRI scanning. We calculated aPWV by measuring time differences and distances between pulse waves in the carotid and femoral arteries. Using automated MRI analysis, we obtained white matter lesion volumes. Infarcts and microbleeds were rated visually. We used linear and logistic regression models to associate aPWV with small vessel disease, adjusting for age, sex, mean arterial pressure, and heart rate Results-In the study group, higher aPWV was associated with larger white matter lesion volume (difference in volume per SD increase in aPWV 0.07; 95% CI, 0.02-0.12) but not with lacunar infarcts or microbleeds. In persons with uncontrolled hypertension, higher aPWV was significantly associated with larger white matter lesion volume (difference in volume per SD increase in aPWV 0.09; 95% CI, 0.00-0.18), deep or infratentorial microbleeds (OR, 2.13; 95% CI, 1.16-3.91), and to a lesser extent also Conclusions-In our study, increased arterial stiffness is associated with a larger volume of white matter lesions. (Stroke. 2012; 43:2637-2642.)
Original languageUndefined/Unknown
Pages (from-to)2637-2642
Number of pages6
JournalStroke
Volume43
Issue number10
DOIs
Publication statusPublished - 2012

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