TY - JOUR
T1 - Arterial wall properties in patients with renal failure
AU - Konings, Constantijn J.A.M.
AU - Dammers, Ruben
AU - Rensma, Pieter L.
AU - Kooman, Jeroen P.
AU - Hoeks, Arnold P.G.
AU - Kornet, Lilian
AU - Gladziwa, Ulrich
AU - Van der Sande, Frank M.
AU - Leunissen, Karel M.L.
PY - 2002
Y1 - 2002
N2 - Hemodialysis (HD) patients commonly show abnormalities of the arterial system. Only a few studies have focused on arterial wall properties in patients with early stages of renal insufficiency and patients on peritoneal dialysis (PD) therapy. In this study, the distensibility coefficient (DC), a marker of arterial stiffening and intima media thickness (IMT) of the common carotid artery (CCA) and a surrogate marker of atherosclerosis, was assessed in four age-matched groups of patients: 18 HD patients, 36 PD patients, 30 patients with chronic renal failure (CRF) not yet on dialysis therapy with a creatinine clearance (CCI) between 10 and 70 mL/min, and 25 normotensive controls with normal renal function. Arterial wall properties were assessed by an automated vessel wall detection system. In patients with CRF and HD patients, but not PD patients, the DC of the CCA was significantly reduced (P < 0.05) compared with controls (CRF, 12.6 ± 7.5 10-3/kPa; HD, 11.6 ± 7.6 10-3/kPa; and PD, 14.7 ± 6.2 10-3/kPa compared with controls, 16.7 ± 4.6 10-3/kPa). In patients with CRF, a significant relationship was found between CCI and the DC (r = 0.41; P = 0.02). IMT was not different among patients with CRF (589 ± 115 μm), HD (622 ± 115 μm) and PD patients (585 ± 121 μm), and controls (668 ± 150 μm). In conclusion, compared with controls, the DC of the CCA was significantly reduced in HD patients and those with CRF, but not PD patients. In patients with CRF, the DC correlated significantly with CCI. IMT did not differ between groups of renal patients and controls.
AB - Hemodialysis (HD) patients commonly show abnormalities of the arterial system. Only a few studies have focused on arterial wall properties in patients with early stages of renal insufficiency and patients on peritoneal dialysis (PD) therapy. In this study, the distensibility coefficient (DC), a marker of arterial stiffening and intima media thickness (IMT) of the common carotid artery (CCA) and a surrogate marker of atherosclerosis, was assessed in four age-matched groups of patients: 18 HD patients, 36 PD patients, 30 patients with chronic renal failure (CRF) not yet on dialysis therapy with a creatinine clearance (CCI) between 10 and 70 mL/min, and 25 normotensive controls with normal renal function. Arterial wall properties were assessed by an automated vessel wall detection system. In patients with CRF and HD patients, but not PD patients, the DC of the CCA was significantly reduced (P < 0.05) compared with controls (CRF, 12.6 ± 7.5 10-3/kPa; HD, 11.6 ± 7.6 10-3/kPa; and PD, 14.7 ± 6.2 10-3/kPa compared with controls, 16.7 ± 4.6 10-3/kPa). In patients with CRF, a significant relationship was found between CCI and the DC (r = 0.41; P = 0.02). IMT was not different among patients with CRF (589 ± 115 μm), HD (622 ± 115 μm) and PD patients (585 ± 121 μm), and controls (668 ± 150 μm). In conclusion, compared with controls, the DC of the CCA was significantly reduced in HD patients and those with CRF, but not PD patients. In patients with CRF, the DC correlated significantly with CCI. IMT did not differ between groups of renal patients and controls.
UR - http://www.scopus.com/inward/record.url?scp=0036273934&partnerID=8YFLogxK
U2 - 10.1053/ajkd.2002.33392
DO - 10.1053/ajkd.2002.33392
M3 - Article
C2 - 12046032
AN - SCOPUS:0036273934
SN - 0272-6386
VL - 39
SP - 1206
EP - 1212
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 6
ER -