Artificial nutrition and hydration in the last week of life in cancer patients. A systematic literature review of practices and effects

Natasja Raijmakers, Lia Zuylen, M Costantini, A Caraceni, J Clark, G Lundquist, R Voltz, JE Ellershaw, Agnes van der Heide

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97 Citations (Scopus)


Materials and methods: We systematically searched for papers in PubMed, CINAHL, PsycInfo and EMBASE. All English papers published between January 1998 and July 2009 that contained data on frequencies or effects of AN or AH in cancer patients in the last days of life were included. Results: Reported percentages of patients receiving AN or AH in the last week of life varied from 3% to 53% and from 12% to 88%, respectively. Five studies reported on the effects of AH: two found positive effects (less chronic nausea, less physical dehydration signs), two found negative effects (more ascites, more intestinal drainage) and four found also no effects on terminal delirium, thirst, chronic nausea and fluid overload. No study reported on the sole effect of AN. Conclusions: Providing AN or AH to cancer patients who are in the last week of life is a frequent practice. The effects on comfort, symptoms and length of survival seem limited. Further research will contribute to better understanding of this important topic in end-of-life care.
Original languageUndefined/Unknown
Pages (from-to)1478-1486
Number of pages9
JournalAnnals of Oncology
Issue number7
Publication statusPublished - 2011

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