Aspergillus-related lung disease in people with cystic fibrosis: can imaging help us to diagnose disease?

Qianting Lv, Bernadette B.L.J. Elders, Adilia Warris, Daan Caudri, Pierluigi Ciet, Harm A.W.M. Tiddens

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In people with cystic fibrosis (PwCF), viscous sputum and dysfunction of the mucociliary escalator leads to early and chronic infections. The prevalence of Aspergillus fumigatus in sputum is high in PwCF and the contribution of A. fumigatus to the progression of structural lung disease has been reported. However, overall, relatively little is known about the contribution of A. fumigatus to CF lung disease. More knowledge is needed to aid clinical decisions on whether to start antifungal treatment. In this review, we give an overview of A. fumigatus colonisation and infection in PwCF and the different types of pulmonary disease caused by it. Furthermore, we discuss the current evidence for structural lung damage associated with A. fumigatus in PwCF on chest computed tomography and magnetic resonance imaging. We conclude that radiological outcomes to identify disease caused by A. fumigatus can be important for clinical studies and management.

Original languageEnglish
Article number210103
JournalEuropean respiratory review : an official journal of the European Respiratory Society
Issue number162
Publication statusPublished - 31 Dec 2021

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Copyright ©The authors 2021.

Research programs

  • EMC OR-01-54-02


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