Assessment of the antiviral properties of recombinant surfactant protein D against influenza B virus in vitro

Marine Hillaire, M van Eijk, Stella Trierum, Nella Nieuwkoop, Debby van Riel, Ron Fouchier, Thijs Kuiken, Ab Osterhaus, HP Haagsman, Guus Rimmelzwaan

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9 Citations (Scopus)

Abstract

The armamentarium of antiviral drugs against influenza viruses is limited. Furthermore, influenza viruses emerge that are resistant to existing antiviral drugs like the M2 and NA inhibitors. Therefore, there is an urgent need for the development of novel classes of antiviral drugs. Here we investigated the antiviral properties of recombinant porcine surfactant protein D (RpSP-D), an innate defense molecule with lectin properties, against influenza B viruses. We have previously shown that porcine SP-D has more potent neutralizing activity against influenza A viruses than human SP-D. Here we show that RpSP-D neutralizes influenza B viruses efficiently and inhibited the binding of these viruses to epithelial cells of the human trachea. (C) 2014 Elsevier B.V. All rights reserved.
Original languageUndefined/Unknown
Pages (from-to)43-46
Number of pages4
JournalVirus Research
Volume195
DOIs
Publication statusPublished - 2015

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