Associatie tussen bloeddrukbeheersing en therapietrouw aan antihypertensiva bij patiënten met milde tot matige hypertensie: Een observationen studie

Translated title of the contribution: Association between blood pressure control and medication adherence in patients with mild to moderate hypertension: An observational study

Hein A. Van Onzenoort, Willem J. Verberk, Leo M. Stolk, Alfons G. Kessels, Patricia J. Nelemans, Cees Neef, Paul Hugo M. Van Der Kuy, Peter W. De Leeuw

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective: To investigate the association between blood pressure control and adherence to medication measured by electronic monitoring in hypertensive patients. Design: Observational study. Methods: Patients with mild to moderate hypertension originated from the Home versus Office blood pressure MEasurements: Reduction of Unnecessary treatment Study (HUMERUS). Primary aim of the HUMERUS study was to investigate the effect of self-measurement of blood pressure on lowering blood pressure and on the number of antihypertensive drugs. Blood pressure target on which treatment decisions were made was set at <140/90 (systolic/diastolic) mmHg. Adherence to medication was assessed electronically in 228 patients during one year and was expressed as a percentage of days with correct dosing. Results: At the end of the follow-up period mean blood pressure decreased from 169/99 mmHg to 140/83 mmHg. Mean adherence to medication was 88% (standard deviation 11%) and the mean number of antihypertensive drugs was 1.7. Patients who reached blood pressure targets were not more adherent than patients who did not reach blood pressure targets (RR = 0.99; 95% confidence interval 0.75-1.30). However, during the first five visits patients who reached blood pressure targets were more likely to be adherent than patients who did not reach blood pressure targets (RR = 1.75). Conclusion: No association was found between blood pressure control and adherence to medication which might be explained by the high adherence among our patients.

Translated title of the contributionAssociation between blood pressure control and medication adherence in patients with mild to moderate hypertension: An observational study
Original languageDutch
Pages (from-to)179-182
Number of pages4
JournalPharmaceutische Weekblad Wetenschappelijk Platform
Volume2
Issue number8
Publication statusPublished - 17 Oct 2008
Externally publishedYes

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