Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

EK Speliotes; CJ Willer; SI Berndt; KL Monda; G Thorleifsson; AU Jackson; HL Allen; CM Lindgren; J Luan; R Magi; JC Randall; S Vedantam; TW Winkler; L Qi; T Workalemahu; IM Heid; V Steinthorsdottir; HM Stringham; MN Weedon; E Wheeler; AR Wood; T Ferreira; RJ Weyant; AV Segre; Karol Estrada Gil; LM Liang; J Nemesh; JH Park; S Gustafsson; TO Kilpelanen; JA Yang; N Bouatia-Naji; T Esko; MF Feitosa; Z Kutalik; M Mangino; S Raychaudhuri; A Scherag; AV Smith; R Welch; JH Zhao; KK Aben; DM Absher; Najaf Amin; AL Dixon; E Fisher; NL Glazer; ME Goddard; NL Heard-Costa; V Hoesel; JJ (Jouke Jan) Hottenga; A Johansson; T Johnson; S Ketkar; C Lamina; SX Li; MF Moffatt; RH Myers; N Narisu; JRB Perry; Marjolein Peters; M Preuss; S Ripatti; Fernando Rivadeneira; C Sandholt; LJ Scott; NJ Timpson; JP Tyrer; S van Wingerden; RM Watanabe; CC White; F Wiklund; C Barlassina; DI Chasman; MN Cooper; JO Jansson; RW Lawrence; N Pellikka; I Prokopenko; JX Shi; E Thiering; H Alavere; MTS Alibrandi; P Almgren; AM Arnold; T Aspelund; LD Atwood; B Balkau; AJ Balmforth; AJ Bennett; Y Ben-Shlomo; RN Bergman; S Bergmann; H Biebermann; AIF Blakemore; T Boes; LL Bonnycastle; SR Bornstein; MJ Brown; TA Buchanan; F Busonero; H Campbell; FP Cappuccio; C Cavalcanti-Proenca; YDI Chen; CM Chen; PS Chines; R Clarke; L Coin; J Connell; INM Day; Mariska Heijer; JB Duan; S Ebrahim; P Elliott; R Elosua; G Eiriksdottir; MR Erdos; JG Eriksson; MF Facheris; SB Felix; P Fischer-Posovszky; AR Folsom; N Friedrich; NB Freimer; M Fu; S Gaget; PV Gejman; EJC de Geus; C Gieger; AP Gjesing; A Goel; P Goyette; H Grallert; J Grassler; DM Greenawalt; CJ Groves; V Gudnason; C Guiducci; AL Hartikainen; N Hassanali; AS Hall; AS Havulinna; C Hayward; AC Heath; C Hengstenberg; AA Hicks; A Hinney; Bert Hofman; G Homuth; J Hui; W Igl; C Iribarren; B Isomaa; KB Jacobs; I Jarick; E Jewell; U John; T Jorgensen; P Jousilahti; A Jula; M Kaakinen; E Kajantie; LM Kaplan; S Kathiresan; J Kettunen; L Kinnunen; JW Knowles; I Kolcic; IR Konig; S Koskinen; P Kovacs; J Kuusisto; P Kraft; K Kvaloy; J Laitinen; O Lantieri; C Lanzani; LJ (Lenore) Launer; C Lecoeur; T Lehtimaki; G Lettre; JJ Liu; ML Lokki; M Lorentzon; RN Luben; B Ludwig; P Manunta; D Marek; M (Michel) Marre; NG Martin; WL McArdle; A McCarthy; B McKnight; T Meitinger; O Melander; D Meyre; K Midthjell; GW Montgomery; MA Morken; AP Morris; R Mulic; JS Ngwa; M Nelis; MJ Neville; DR Nyholt; CJ O'Donnell; S O'Rahilly; KK Ong; Ben Oostra; G Pare; AN Parker; M Perola; I Pichler; KH Pietilainen; CGP Platou; O Polasek; A Pouta; S Rafelt; O Raitakari; NW Rayner; M Ridderstrale; W Rief; A Ruokonen; NR Robertson; P Rzehak; V Salomaa; AR Sanders; MS Sandhu; S Sanna; J Saramies; MJ Savolainen; S Scherag; S Schipf; S Schreiber; H Schunkert; K Silander; J Sinisalo; DS Siscovick; JH Smit; N Soranzo; U Sovio; J Stephens; I Surakka; AJ Swift; ML Tammesoo; JC Tardif; M Teder-Laving; TM Teslovich; JR Thompson; B Thomson; A Tonjes; T Tuomi; Joyce van Meurs; GJ van Ommen; V Vatin; J Viikari; S Visvikis-Siest; V Vitart; CIG Vogel; BF Voight; LL Waite; H Wallaschofski; GB Walters; E Widen; S Wiegand; SH Wild; G Willemsen; DR Witte; JCM Witteman; JF Xu; QY Zhang; T Hansen; L Zgaga; A Ziegler; P Zitting; JP Beilby; IS Farooqi; J Hebebrand; HV Huikuri; AL James; M Kahonen; DF Levinson; F Macciardi; MS Nieminen; C Ohlsson; LJ Palmer; PM Ridker; M Stumvoll; JS Beckmann; H Boeing; E Boerwinkle; DI Boomsma; MJ Caulfield; SJ Chanock; FS Collins; LA Cupples; GD Smith; J Erdmann; P Froguel; H Gronberg; U Gyllensten; P Hall; TB Harris; AT Hattersley; RB Hayes; J (Joachim) Heinrich; FB Hu; K Hveem; T Illig; MR Jarvelin; J Kaprio; F Karpe; KT Khaw; LA Kiemeney; H Krude; M Laakso; DA Lawlor; A Metspalu; PB Munroe; WH Ouwehand; O Pedersen; BW Penninx; A Peters; PP Pramstaller; T Quertermous; T Reinehr; A Rissanen; I Rudan; NJ Samani; PEH Schwarz; AR Shuldiner; TD Spector; J Tuomilehto; M Uda; André Uitterlinden; TT Valle; M Wabitsch; G Waeber; NJ Wareham; H Watkins; JF Wilson; AF Wright; M.C. Zillikens; N Chatterjee; SA McCarroll; S Purcell; EE Schadt; PM Visscher; TL Assimes; IB Borecki; P Deloukas; CS Fox; LC Groop; T Haritunians; DJ Hunter; RC Kaplan; KL Mohlke; JR O'Connell; L Peltonen; D Schlessinger; DP Strachan; Cornelia Duijn; HE Wichmann; TM Frayling; U Thorsteinsdottir; GR Abecasis; I Barroso; M Boehnke; K Stefansson; KE North; MI McCarthy; JN Hirschhorn; E Ingelsson; RJF Loos

doi:10.1038/ng.686

Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

EK Speliotes, CJ Willer, SI Berndt, KL Monda, G Thorleifsson, AU Jackson, HL Allen, CM Lindgren, J Luan, R Magi, JC Randall, S Vedantam, TW Winkler, L Qi, T Workalemahu, IM Heid, V Steinthorsdottir, HM Stringham, MN Weedon, E WheelerAR Wood, T Ferreira, RJ Weyant, AV Segre, Karol Estrada Gil, LM Liang, J Nemesh, JH Park, S Gustafsson, TO Kilpelanen, JA Yang, N Bouatia-Naji, T Esko, MF Feitosa, Z Kutalik, M Mangino, S Raychaudhuri, A Scherag, AV Smith, R Welch, JH Zhao, KK Aben, DM Absher, Najaf Amin, AL Dixon, E Fisher, NL Glazer, ME Goddard, NL Heard-Costa, V Hoesel, JJ (Jouke Jan) Hottenga, A Johansson, T Johnson, S Ketkar, C Lamina, SX Li, MF Moffatt, RH Myers, N Narisu, JRB Perry, Marjolein Peters, M Preuss, S Ripatti, Fernando Rivadeneira, C Sandholt, LJ Scott, NJ Timpson, JP Tyrer, S van Wingerden, RM Watanabe, CC White, F Wiklund, C Barlassina, DI Chasman, MN Cooper, JO Jansson, RW Lawrence, N Pellikka, I Prokopenko, JX Shi, E Thiering, H Alavere, MTS Alibrandi, P Almgren, AM Arnold, T Aspelund, LD Atwood, B Balkau, AJ Balmforth, AJ Bennett, Y Ben-Shlomo, RN Bergman, S Bergmann, H Biebermann, AIF Blakemore, T Boes, LL Bonnycastle, SR Bornstein, MJ Brown, TA Buchanan, F Busonero, H Campbell, FP Cappuccio, C Cavalcanti-Proenca, YDI Chen, CM Chen, PS Chines, R Clarke, L Coin, J Connell, INM Day, Mariska Heijer, JB Duan, S Ebrahim, P Elliott, R Elosua, G Eiriksdottir, MR Erdos, JG Eriksson, MF Facheris, SB Felix, P Fischer-Posovszky, AR Folsom, N Friedrich, NB Freimer, M Fu, S Gaget, PV Gejman, EJC de Geus, C Gieger, AP Gjesing, A Goel, P Goyette, H Grallert, J Grassler, DM Greenawalt, CJ Groves, V Gudnason, C Guiducci, AL Hartikainen, N Hassanali, AS Hall, AS Havulinna, C Hayward, AC Heath, C Hengstenberg, AA Hicks, A Hinney, Bert Hofman, G Homuth, J Hui, W Igl, C Iribarren, B Isomaa, KB Jacobs, I Jarick, E Jewell, U John, T Jorgensen, P Jousilahti, A Jula, M Kaakinen, E Kajantie, LM Kaplan, S Kathiresan, J Kettunen, L Kinnunen, JW Knowles, I Kolcic, IR Konig, S Koskinen, P Kovacs, J Kuusisto, P Kraft, K Kvaloy, J Laitinen, O Lantieri, C Lanzani, LJ (Lenore) Launer, C Lecoeur, T Lehtimaki, G Lettre, JJ Liu, ML Lokki, M Lorentzon, RN Luben, B Ludwig, P Manunta, D Marek, M (Michel) Marre, NG Martin, WL McArdle, A McCarthy, B McKnight, T Meitinger, O Melander, D Meyre, K Midthjell, GW Montgomery, MA Morken, AP Morris, R Mulic, JS Ngwa, M Nelis, MJ Neville, DR Nyholt, CJ O'Donnell, S O'Rahilly, KK Ong, Ben Oostra, G Pare, AN Parker, M Perola, I Pichler, KH Pietilainen, CGP Platou, O Polasek, A Pouta, S Rafelt, O Raitakari, NW Rayner, M Ridderstrale, W Rief, A Ruokonen, NR Robertson, P Rzehak, V Salomaa, AR Sanders, MS Sandhu, S Sanna, J Saramies, MJ Savolainen, S Scherag, S Schipf, S Schreiber, H Schunkert, K Silander, J Sinisalo, DS Siscovick, JH Smit, N Soranzo, U Sovio, J Stephens, I Surakka, AJ Swift, ML Tammesoo, JC Tardif, M Teder-Laving, TM Teslovich, JR Thompson, B Thomson, A Tonjes, T Tuomi, Joyce van Meurs, GJ van Ommen, V Vatin, J Viikari, S Visvikis-Siest, V Vitart, CIG Vogel, BF Voight, LL Waite, H Wallaschofski, GB Walters, E Widen, S Wiegand, SH Wild, G Willemsen, DR Witte, JCM Witteman, JF Xu, QY Zhang, T Hansen, L Zgaga, A Ziegler, P Zitting, JP Beilby, IS Farooqi, J Hebebrand, HV Huikuri, AL James, M Kahonen, DF Levinson, F Macciardi, MS Nieminen, C Ohlsson, LJ Palmer, PM Ridker, M Stumvoll, JS Beckmann, H Boeing, E Boerwinkle, DI Boomsma, MJ Caulfield, SJ Chanock, FS Collins, LA Cupples, GD Smith, J Erdmann, P Froguel, H Gronberg, U Gyllensten, P Hall, TB Harris, AT Hattersley, RB Hayes, J (Joachim) Heinrich, FB Hu, K Hveem, T Illig, MR Jarvelin, J Kaprio, F Karpe, KT Khaw, LA Kiemeney, H Krude, M Laakso, DA Lawlor, A Metspalu, PB Munroe, WH Ouwehand, O Pedersen, BW Penninx, A Peters, PP Pramstaller, T Quertermous, T Reinehr, A Rissanen, I Rudan, NJ Samani, PEH Schwarz, AR Shuldiner, TD Spector, J Tuomilehto, M Uda, André Uitterlinden, TT Valle, M Wabitsch, G Waeber, NJ Wareham, H Watkins, JF Wilson, AF Wright, M.C. Zillikens, N Chatterjee, SA McCarroll, S Purcell, EE Schadt, PM Visscher, TL Assimes, IB Borecki, P Deloukas, CS Fox, LC Groop, T Haritunians, DJ Hunter, RC Kaplan, KL Mohlke, JR O'Connell, L Peltonen, D Schlessinger, DP Strachan, Cornelia Duijn, HE Wichmann, TM Frayling, U Thorsteinsdottir, GR Abecasis, I Barroso, M Boehnke, K Stefansson, KE North, MI McCarthy, JN Hirschhorn, E Ingelsson, RJF Loos

Research output: Contribution to journal › Article › Academic › peer-review

2426 Citations (Scopus)

Abstract

Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

Original language	Undefined/Unknown
Pages (from-to)	937-U53
Journal	Nature Genetics
Volume	42
Issue number	11
DOIs	https://doi.org/10.1038/ng.686
Publication status	Published - 2010

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EMC MM-01-39-02

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This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1038/ng.686

http://hdl.handle.net/1765/28292

Cite this

Speliotes, EK., Willer, CJ., Berndt, SI., Monda, KL., Thorleifsson, G., Jackson, AU., Allen, HL., Lindgren, CM., Luan, J., Magi, R., Randall, JC., Vedantam, S., Winkler, TW., Qi, L., Workalemahu, T., Heid, IM., Steinthorsdottir, V., Stringham, HM., Weedon, MN., ... Loos, RJF. (2010). Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nature Genetics, 42(11), 937-U53. https://doi.org/10.1038/ng.686

@article{773f70d2b8fc4f0bac31bc5938c70e75,

title = "Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index",

abstract = "Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.",

author = "EK Speliotes and CJ Willer and SI Berndt and KL Monda and G Thorleifsson and AU Jackson and HL Allen and CM Lindgren and J Luan and R Magi and JC Randall and S Vedantam and TW Winkler and L Qi and T Workalemahu and IM Heid and V Steinthorsdottir and HM Stringham and MN Weedon and E Wheeler and AR Wood and T Ferreira and RJ Weyant and AV Segre and {Estrada Gil}, Karol and LM Liang and J Nemesh and JH Park and S Gustafsson and TO Kilpelanen and JA Yang and N Bouatia-Naji and T Esko and MF Feitosa and Z Kutalik and M Mangino and S Raychaudhuri and A Scherag and AV Smith and R Welch and JH Zhao and KK Aben and DM Absher and Najaf Amin and AL Dixon and E Fisher and NL Glazer and ME Goddard and NL Heard-Costa and V Hoesel and Hottenga, {JJ (Jouke Jan)} and A Johansson and T Johnson and S Ketkar and C Lamina and SX Li and MF Moffatt and RH Myers and N Narisu and JRB Perry and Marjolein Peters and M Preuss and S Ripatti and Fernando Rivadeneira and C Sandholt and LJ Scott and NJ Timpson and JP Tyrer and {van Wingerden}, S and RM Watanabe and CC White and F Wiklund and C Barlassina and DI Chasman and MN Cooper and JO Jansson and RW Lawrence and N Pellikka and I Prokopenko and JX Shi and E Thiering and H Alavere and MTS Alibrandi and P Almgren and AM Arnold and T Aspelund and LD Atwood and B Balkau and AJ Balmforth and AJ Bennett and Y Ben-Shlomo and RN Bergman and S Bergmann and H Biebermann and AIF Blakemore and T Boes and LL Bonnycastle and SR Bornstein and MJ Brown and TA Buchanan and F Busonero and H Campbell and FP Cappuccio and C Cavalcanti-Proenca and YDI Chen and CM Chen and PS Chines and R Clarke and L Coin and J Connell and INM Day and Mariska Heijer and JB Duan and S Ebrahim and P Elliott and R Elosua and G Eiriksdottir and MR Erdos and JG Eriksson and MF Facheris and SB Felix and P Fischer-Posovszky and AR Folsom and N Friedrich and NB Freimer and M Fu and S Gaget and PV Gejman and {de Geus}, EJC and C Gieger and AP Gjesing and A Goel and P Goyette and H Grallert and J Grassler and DM Greenawalt and CJ Groves and V Gudnason and C Guiducci and AL Hartikainen and N Hassanali and AS Hall and AS Havulinna and C Hayward and AC Heath and C Hengstenberg and AA Hicks and A Hinney and Bert Hofman and G Homuth and J Hui and W Igl and C Iribarren and B Isomaa and KB Jacobs and I Jarick and E Jewell and U John and T Jorgensen and P Jousilahti and A Jula and M Kaakinen and E Kajantie and LM Kaplan and S Kathiresan and J Kettunen and L Kinnunen and JW Knowles and I Kolcic and IR Konig and S Koskinen and P Kovacs and J Kuusisto and P Kraft and K Kvaloy and J Laitinen and O Lantieri and C Lanzani and Launer, {LJ (Lenore)} and C Lecoeur and T Lehtimaki and G Lettre and JJ Liu and ML Lokki and M Lorentzon and RN Luben and B Ludwig and P Manunta and D Marek and Marre, {M (Michel)} and NG Martin and WL McArdle and A McCarthy and B McKnight and T Meitinger and O Melander and D Meyre and K Midthjell and GW Montgomery and MA Morken and AP Morris and R Mulic and JS Ngwa and M Nelis and MJ Neville and DR Nyholt and CJ O'Donnell and S O'Rahilly and KK Ong and Ben Oostra and G Pare and AN Parker and M Perola and I Pichler and KH Pietilainen and CGP Platou and O Polasek and A Pouta and S Rafelt and O Raitakari and NW Rayner and M Ridderstrale and W Rief and A Ruokonen and NR Robertson and P Rzehak and V Salomaa and AR Sanders and MS Sandhu and S Sanna and J Saramies and MJ Savolainen and S Scherag and S Schipf and S Schreiber and H Schunkert and K Silander and J Sinisalo and DS Siscovick and JH Smit and N Soranzo and U Sovio and J Stephens and I Surakka and AJ Swift and ML Tammesoo and JC Tardif and M Teder-Laving and TM Teslovich and JR Thompson and B Thomson and A Tonjes and T Tuomi and {van Meurs}, Joyce and {van Ommen}, GJ and V Vatin and J Viikari and S Visvikis-Siest and V Vitart and CIG Vogel and BF Voight and LL Waite and H Wallaschofski and GB Walters and E Widen and S Wiegand and SH Wild and G Willemsen and DR Witte and JCM Witteman and JF Xu and QY Zhang and T Hansen and L Zgaga and A Ziegler and P Zitting and JP Beilby and IS Farooqi and J Hebebrand and HV Huikuri and AL James and M Kahonen and DF Levinson and F Macciardi and MS Nieminen and C Ohlsson and LJ Palmer and PM Ridker and M Stumvoll and JS Beckmann and H Boeing and E Boerwinkle and DI Boomsma and MJ Caulfield and SJ Chanock and FS Collins and LA Cupples and GD Smith and J Erdmann and P Froguel and H Gronberg and U Gyllensten and P Hall and TB Harris and AT Hattersley and RB Hayes and Heinrich, {J (Joachim)} and FB Hu and K Hveem and T Illig and MR Jarvelin and J Kaprio and F Karpe and KT Khaw and LA Kiemeney and H Krude and M Laakso and DA Lawlor and A Metspalu and PB Munroe and WH Ouwehand and O Pedersen and BW Penninx and A Peters and PP Pramstaller and T Quertermous and T Reinehr and A Rissanen and I Rudan and NJ Samani and PEH Schwarz and AR Shuldiner and TD Spector and J Tuomilehto and M Uda and Andr{\'e} Uitterlinden and TT Valle and M Wabitsch and G Waeber and NJ Wareham and H Watkins and JF Wilson and AF Wright and M.C. Zillikens and N Chatterjee and SA McCarroll and S Purcell and EE Schadt and PM Visscher and TL Assimes and IB Borecki and P Deloukas and CS Fox and LC Groop and T Haritunians and DJ Hunter and RC Kaplan and KL Mohlke and JR O'Connell and L Peltonen and D Schlessinger and DP Strachan and Cornelia Duijn and HE Wichmann and TM Frayling and U Thorsteinsdottir and GR Abecasis and I Barroso and M Boehnke and K Stefansson and KE North and MI McCarthy and JN Hirschhorn and E Ingelsson and RJF Loos",

year = "2010",

doi = "10.1038/ng.686",

language = "Undefined/Unknown",

volume = "42",

pages = "937--U53",

journal = "Nature Genetics",

issn = "1061-4036",

publisher = "Nature Research",

number = "11",

}

Speliotes, EK, Willer, CJ, Berndt, SI, Monda, KL, Thorleifsson, G, Jackson, AU, Allen, HL, Lindgren, CM, Luan, J, Magi, R, Randall, JC, Vedantam, S, Winkler, TW, Qi, L, Workalemahu, T, Heid, IM, Steinthorsdottir, V, Stringham, HM, Weedon, MN, Wheeler, E, Wood, AR, Ferreira, T, Weyant, RJ, Segre, AV, Estrada Gil, K, Liang, LM, Nemesh, J, Park, JH, Gustafsson, S, Kilpelanen, TO, Yang, JA, Bouatia-Naji, N, Esko, T, Feitosa, MF, Kutalik, Z, Mangino, M, Raychaudhuri, S, Scherag, A, Smith, AV, Welch, R, Zhao, JH, Aben, KK, Absher, DM, Amin, N, Dixon, AL, Fisher, E, Glazer, NL, Goddard, ME, Heard-Costa, NL, Hoesel, V, Hottenga, JJ, Johansson, A, Johnson, T, Ketkar, S, Lamina, C, Li, SX, Moffatt, MF, Myers, RH, Narisu, N, Perry, JRB, Peters, M, Preuss, M, Ripatti, S, Rivadeneira, F, Sandholt, C, Scott, LJ, Timpson, NJ, Tyrer, JP, van Wingerden, S, Watanabe, RM, White, CC, Wiklund, F, Barlassina, C, Chasman, DI, Cooper, MN, Jansson, JO, Lawrence, RW, Pellikka, N, Prokopenko, I, Shi, JX, Thiering, E, Alavere, H, Alibrandi, MTS, Almgren, P, Arnold, AM, Aspelund, T, Atwood, LD, Balkau, B, Balmforth, AJ, Bennett, AJ, Ben-Shlomo, Y, Bergman, RN, Bergmann, S, Biebermann, H, Blakemore, AIF, Boes, T, Bonnycastle, LL, Bornstein, SR, Brown, MJ, Buchanan, TA, Busonero, F, Campbell, H, Cappuccio, FP, Cavalcanti-Proenca, C, Chen, YDI, Chen, CM, Chines, PS, Clarke, R, Coin, L, Connell, J, Day, INM, Heijer, M, Duan, JB, Ebrahim, S, Elliott, P, Elosua, R, Eiriksdottir, G, Erdos, MR, Eriksson, JG, Facheris, MF, Felix, SB, Fischer-Posovszky, P, Folsom, AR, Friedrich, N, Freimer, NB, Fu, M, Gaget, S, Gejman, PV, de Geus, EJC, Gieger, C, Gjesing, AP, Goel, A, Goyette, P, Grallert, H, Grassler, J, Greenawalt, DM, Groves, CJ, Gudnason, V, Guiducci, C, Hartikainen, AL, Hassanali, N, Hall, AS, Havulinna, AS, Hayward, C, Heath, AC, Hengstenberg, C, Hicks, AA, Hinney, A, Hofman, B, Homuth, G, Hui, J, Igl, W, Iribarren, C, Isomaa, B, Jacobs, KB, Jarick, I, Jewell, E, John, U, Jorgensen, T, Jousilahti, P, Jula, A, Kaakinen, M, Kajantie, E, Kaplan, LM, Kathiresan, S, Kettunen, J, Kinnunen, L, Knowles, JW, Kolcic, I, Konig, IR, Koskinen, S, Kovacs, P, Kuusisto, J, Kraft, P, Kvaloy, K, Laitinen, J, Lantieri, O, Lanzani, C, Launer, LJ, Lecoeur, C, Lehtimaki, T, Lettre, G, Liu, JJ, Lokki, ML, Lorentzon, M, Luben, RN, Ludwig, B, Manunta, P, Marek, D, Marre, M, Martin, NG, McArdle, WL, McCarthy, A, McKnight, B, Meitinger, T, Melander, O, Meyre, D, Midthjell, K, Montgomery, GW, Morken, MA, Morris, AP, Mulic, R, Ngwa, JS, Nelis, M, Neville, MJ, Nyholt, DR, O'Donnell, CJ, O'Rahilly, S, Ong, KK, Oostra, B, Pare, G, Parker, AN, Perola, M, Pichler, I, Pietilainen, KH, Platou, CGP, Polasek, O, Pouta, A, Rafelt, S, Raitakari, O, Rayner, NW, Ridderstrale, M, Rief, W, Ruokonen, A, Robertson, NR, Rzehak, P, Salomaa, V, Sanders, AR, Sandhu, MS, Sanna, S, Saramies, J, Savolainen, MJ, Scherag, S, Schipf, S, Schreiber, S, Schunkert, H, Silander, K, Sinisalo, J, Siscovick, DS, Smit, JH, Soranzo, N, Sovio, U, Stephens, J, Surakka, I, Swift, AJ, Tammesoo, ML, Tardif, JC, Teder-Laving, M, Teslovich, TM, Thompson, JR, Thomson, B, Tonjes, A, Tuomi, T, van Meurs, J, van Ommen, GJ, Vatin, V, Viikari, J, Visvikis-Siest, S, Vitart, V, Vogel, CIG, Voight, BF, Waite, LL, Wallaschofski, H, Walters, GB, Widen, E, Wiegand, S, Wild, SH, Willemsen, G, Witte, DR, Witteman, JCM, Xu, JF, Zhang, QY, Hansen, T, Zgaga, L, Ziegler, A, Zitting, P, Beilby, JP, Farooqi, IS, Hebebrand, J, Huikuri, HV, James, AL, Kahonen, M, Levinson, DF, Macciardi, F, Nieminen, MS, Ohlsson, C, Palmer, LJ, Ridker, PM, Stumvoll, M, Beckmann, JS, Boeing, H, Boerwinkle, E, Boomsma, DI, Caulfield, MJ, Chanock, SJ, Collins, FS, Cupples, LA, Smith, GD, Erdmann, J, Froguel, P, Gronberg, H, Gyllensten, U, Hall, P, Harris, TB, Hattersley, AT, Hayes, RB, Heinrich, J, Hu, FB, Hveem, K, Illig, T, Jarvelin, MR, Kaprio, J, Karpe, F, Khaw, KT, Kiemeney, LA, Krude, H, Laakso, M, Lawlor, DA, Metspalu, A, Munroe, PB, Ouwehand, WH, Pedersen, O, Penninx, BW, Peters, A, Pramstaller, PP, Quertermous, T, Reinehr, T, Rissanen, A, Rudan, I, Samani, NJ, Schwarz, PEH, Shuldiner, AR, Spector, TD, Tuomilehto, J, Uda, M, Uitterlinden, A, Valle, TT, Wabitsch, M, Waeber, G, Wareham, NJ, Watkins, H, Wilson, JF, Wright, AF, Zillikens, MC, Chatterjee, N, McCarroll, SA, Purcell, S, Schadt, EE, Visscher, PM, Assimes, TL, Borecki, IB, Deloukas, P, Fox, CS, Groop, LC, Haritunians, T, Hunter, DJ, Kaplan, RC, Mohlke, KL, O'Connell, JR, Peltonen, L, Schlessinger, D, Strachan, DP, Duijn, C, Wichmann, HE, Frayling, TM, Thorsteinsdottir, U, Abecasis, GR, Barroso, I, Boehnke, M, Stefansson, K, North, KE, McCarthy, MI, Hirschhorn, JN, Ingelsson, E & Loos, RJF 2010, 'Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index', Nature Genetics, vol. 42, no. 11, pp. 937-U53. https://doi.org/10.1038/ng.686

TY - JOUR

T1 - Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index

AU - Speliotes, EK

AU - Willer, CJ

AU - Berndt, SI

AU - Monda, KL

AU - Thorleifsson, G

AU - Jackson, AU

AU - Allen, HL

AU - Lindgren, CM

AU - Luan, J

AU - Magi, R

AU - Randall, JC

AU - Vedantam, S

AU - Winkler, TW

AU - Qi, L

AU - Workalemahu, T

AU - Heid, IM

AU - Steinthorsdottir, V

AU - Stringham, HM

AU - Weedon, MN

AU - Wheeler, E

AU - Wood, AR

AU - Ferreira, T

AU - Weyant, RJ

AU - Segre, AV

AU - Estrada Gil, Karol

AU - Liang, LM

AU - Nemesh, J

AU - Park, JH

AU - Gustafsson, S

AU - Kilpelanen, TO

AU - Yang, JA

AU - Bouatia-Naji, N

AU - Esko, T

AU - Feitosa, MF

AU - Kutalik, Z

AU - Mangino, M

AU - Raychaudhuri, S

AU - Scherag, A

AU - Smith, AV

AU - Welch, R

AU - Zhao, JH

AU - Aben, KK

AU - Absher, DM

AU - Amin, Najaf

AU - Dixon, AL

AU - Fisher, E

AU - Glazer, NL

AU - Goddard, ME

AU - Heard-Costa, NL

AU - Hoesel, V

AU - Hottenga, JJ (Jouke Jan)

AU - Johansson, A

AU - Johnson, T

AU - Ketkar, S

AU - Lamina, C

AU - Li, SX

AU - Moffatt, MF

AU - Myers, RH

AU - Narisu, N

AU - Perry, JRB

AU - Peters, Marjolein

AU - Preuss, M

AU - Ripatti, S

AU - Rivadeneira, Fernando

AU - Sandholt, C

AU - Scott, LJ

AU - Timpson, NJ

AU - Tyrer, JP

AU - van Wingerden, S

AU - Watanabe, RM

AU - White, CC

AU - Wiklund, F

AU - Barlassina, C

AU - Chasman, DI

AU - Cooper, MN

AU - Jansson, JO

AU - Lawrence, RW

AU - Pellikka, N

AU - Prokopenko, I

AU - Shi, JX

AU - Thiering, E

AU - Alavere, H

AU - Alibrandi, MTS

AU - Almgren, P

AU - Arnold, AM

AU - Aspelund, T

AU - Atwood, LD

AU - Balkau, B

AU - Balmforth, AJ

AU - Bennett, AJ

AU - Ben-Shlomo, Y

AU - Bergman, RN

AU - Bergmann, S

AU - Biebermann, H

AU - Blakemore, AIF

AU - Boes, T

AU - Bonnycastle, LL

AU - Bornstein, SR

AU - Brown, MJ

AU - Buchanan, TA

AU - Busonero, F

AU - Campbell, H

AU - Cappuccio, FP

AU - Cavalcanti-Proenca, C

AU - Chen, YDI

AU - Chen, CM

AU - Chines, PS

AU - Clarke, R

AU - Coin, L

AU - Connell, J

AU - Day, INM

AU - Heijer, Mariska

AU - Duan, JB

AU - Ebrahim, S

AU - Elliott, P

AU - Elosua, R

AU - Eiriksdottir, G

AU - Erdos, MR

AU - Eriksson, JG

AU - Facheris, MF

AU - Felix, SB

AU - Fischer-Posovszky, P

AU - Folsom, AR

AU - Friedrich, N

AU - Freimer, NB

AU - Fu, M

AU - Gaget, S

AU - Gejman, PV

AU - de Geus, EJC

AU - Gieger, C

AU - Gjesing, AP

AU - Goel, A

AU - Goyette, P

AU - Grallert, H

AU - Grassler, J

AU - Greenawalt, DM

AU - Groves, CJ

AU - Gudnason, V

AU - Guiducci, C

AU - Hartikainen, AL

AU - Hassanali, N

AU - Hall, AS

AU - Havulinna, AS

AU - Hayward, C

AU - Heath, AC

AU - Hengstenberg, C

AU - Hicks, AA

AU - Hinney, A

AU - Hofman, Bert

AU - Homuth, G

AU - Hui, J

AU - Igl, W

AU - Iribarren, C

AU - Isomaa, B

AU - Jacobs, KB

AU - Jarick, I

AU - Jewell, E

AU - John, U

AU - Jorgensen, T

AU - Jousilahti, P

AU - Jula, A

AU - Kaakinen, M

AU - Kajantie, E

AU - Kaplan, LM

AU - Kathiresan, S

AU - Kettunen, J

AU - Kinnunen, L

AU - Knowles, JW

AU - Kolcic, I

AU - Konig, IR

AU - Koskinen, S

AU - Kovacs, P

AU - Kuusisto, J

AU - Kraft, P

AU - Kvaloy, K

AU - Laitinen, J

AU - Lantieri, O

AU - Lanzani, C

AU - Launer, LJ (Lenore)

AU - Lecoeur, C

AU - Lehtimaki, T

AU - Lettre, G

AU - Liu, JJ

AU - Lokki, ML

AU - Lorentzon, M

AU - Luben, RN

AU - Ludwig, B

AU - Manunta, P

AU - Marek, D

AU - Marre, M (Michel)

AU - Martin, NG

AU - McArdle, WL

AU - McCarthy, A

AU - McKnight, B

AU - Meitinger, T

AU - Melander, O

AU - Meyre, D

AU - Midthjell, K

AU - Montgomery, GW

AU - Morken, MA

AU - Morris, AP

AU - Mulic, R

AU - Ngwa, JS

AU - Nelis, M

AU - Neville, MJ

AU - Nyholt, DR

AU - O'Donnell, CJ

AU - O'Rahilly, S

AU - Ong, KK

AU - Oostra, Ben

AU - Pare, G

AU - Parker, AN

AU - Perola, M

AU - Pichler, I

AU - Pietilainen, KH

AU - Platou, CGP

AU - Polasek, O

AU - Pouta, A

AU - Rafelt, S

AU - Raitakari, O

AU - Rayner, NW

AU - Ridderstrale, M

AU - Rief, W

AU - Ruokonen, A

AU - Robertson, NR

AU - Rzehak, P

AU - Salomaa, V

AU - Sanders, AR

AU - Sandhu, MS

AU - Sanna, S

AU - Saramies, J

AU - Savolainen, MJ

AU - Scherag, S

AU - Schipf, S

AU - Schreiber, S

AU - Schunkert, H

AU - Silander, K

AU - Sinisalo, J

AU - Siscovick, DS

AU - Smit, JH

AU - Soranzo, N

AU - Sovio, U

AU - Stephens, J

AU - Surakka, I

AU - Swift, AJ

AU - Tammesoo, ML

AU - Tardif, JC

AU - Teder-Laving, M

AU - Teslovich, TM

AU - Thompson, JR

AU - Thomson, B

AU - Tonjes, A

AU - Tuomi, T

AU - van Meurs, Joyce

AU - van Ommen, GJ

AU - Vatin, V

AU - Viikari, J

AU - Visvikis-Siest, S

AU - Vitart, V

AU - Vogel, CIG

AU - Voight, BF

AU - Waite, LL

AU - Wallaschofski, H

AU - Walters, GB

AU - Widen, E

AU - Wiegand, S

AU - Wild, SH

AU - Willemsen, G

AU - Witte, DR

AU - Witteman, JCM

AU - Xu, JF

AU - Zhang, QY

AU - Hansen, T

AU - Zgaga, L

AU - Ziegler, A

AU - Zitting, P

AU - Beilby, JP

AU - Farooqi, IS

AU - Hebebrand, J

AU - Huikuri, HV

AU - James, AL

AU - Kahonen, M

AU - Levinson, DF

AU - Macciardi, F

AU - Nieminen, MS

AU - Ohlsson, C

AU - Palmer, LJ

AU - Ridker, PM

AU - Stumvoll, M

AU - Beckmann, JS

AU - Boeing, H

AU - Boerwinkle, E

AU - Boomsma, DI

AU - Caulfield, MJ

AU - Chanock, SJ

AU - Collins, FS

AU - Cupples, LA

AU - Smith, GD

AU - Erdmann, J

AU - Froguel, P

AU - Gronberg, H

AU - Gyllensten, U

AU - Hall, P

AU - Harris, TB

AU - Hattersley, AT

AU - Hayes, RB

AU - Heinrich, J (Joachim)

AU - Hu, FB

AU - Hveem, K

AU - Illig, T

AU - Jarvelin, MR

AU - Kaprio, J

AU - Karpe, F

AU - Khaw, KT

AU - Kiemeney, LA

AU - Krude, H

AU - Laakso, M

AU - Lawlor, DA

AU - Metspalu, A

AU - Munroe, PB

AU - Ouwehand, WH

AU - Pedersen, O

AU - Penninx, BW

AU - Peters, A

AU - Pramstaller, PP

AU - Quertermous, T

AU - Reinehr, T

AU - Rissanen, A

AU - Rudan, I

AU - Samani, NJ

AU - Schwarz, PEH

AU - Shuldiner, AR

AU - Spector, TD

AU - Tuomilehto, J

AU - Uda, M

AU - Uitterlinden, André

AU - Valle, TT

AU - Wabitsch, M

AU - Waeber, G

AU - Wareham, NJ

AU - Watkins, H

AU - Wilson, JF

AU - Wright, AF

AU - Zillikens, M.C.

AU - Chatterjee, N

AU - McCarroll, SA

AU - Purcell, S

AU - Schadt, EE

AU - Visscher, PM

AU - Assimes, TL

AU - Borecki, IB

AU - Deloukas, P

AU - Fox, CS

AU - Groop, LC

AU - Haritunians, T

AU - Hunter, DJ

AU - Kaplan, RC

AU - Mohlke, KL

AU - O'Connell, JR

AU - Peltonen, L

AU - Schlessinger, D

AU - Strachan, DP

AU - Duijn, Cornelia

AU - Wichmann, HE

AU - Frayling, TM

AU - Thorsteinsdottir, U

AU - Abecasis, GR

AU - Barroso, I

AU - Boehnke, M

AU - Stefansson, K

AU - North, KE

AU - McCarthy, MI

AU - Hirschhorn, JN

AU - Ingelsson, E

AU - Loos, RJF

PY - 2010

Y1 - 2010

N2 - Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

AB - Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and similar to 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P < 5 x 10(-8)), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.

U2 - 10.1038/ng.686

DO - 10.1038/ng.686

M3 - Article

C2 - 20935630

SN - 1061-4036

VL - 42

SP - 937-U53

JO - Nature Genetics

JF - Nature Genetics

IS - 11

ER -