Association analysis between an epigenetic risk score and blood pressure

Helena Bui; Amena Keshawarz; Mengyao Wang; Mikyeong Lee; Scott M Ratliff; Lisha Lin; Kira S Birditt; Jessica D Faul; Annette Peters; Christian Gieger; Thomas Delerue; Sharon L R Kardia; Wei Zhao; Xiuqing Guo; Jie Yao; Jerome I Rotter; Yi Li; Xue Liu; Dan Liu; Juliana F Tavares; Gökhan Pehlivan; Monique M B Breteler; Irma Karabegovic; Carolina Ochoa-Rosales; Trudy Voortman; Mohsen Ghanbari; Joyce B J van Meurs; Mohamed Kamal Nasr; Marcus Dörr; Hans J Grabe; Stephanie J London; Alexander Teumer; Melanie Waldenberger; David R Weir; Jennifer A Smith; Daniel Levy; Jiantao Ma; Chunyu Liu

doi:10.21203/rs.3.rs-4243866/v1

Association analysis between an epigenetic risk score and blood pressure

Helena Bui, Amena Keshawarz, Mengyao Wang, Mikyeong Lee, Scott M Ratliff, Lisha Lin, Kira S Birditt, Jessica D Faul, Annette Peters, Christian Gieger, Thomas Delerue, Sharon L R Kardia, Wei Zhao, Xiuqing Guo, Jie Yao, Jerome I Rotter, Yi Li, Xue Liu, Dan Liu, Juliana F TavaresGökhan Pehlivan, Monique M B Breteler, Irma Karabegovic, Carolina Ochoa-Rosales, Trudy Voortman, Mohsen Ghanbari, Joyce B J van Meurs, Mohamed Kamal Nasr, Marcus Dörr, Hans J Grabe, Stephanie J London, Alexander Teumer, Melanie Waldenberger, David R Weir, Jennifer A Smith, Daniel Levy, Jiantao Ma, Chunyu Liu

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Abstract

BACKGROUND:

Epigenome-wide association studies have revealed multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases.

RESULTS:

We generated an alcohol consumption epigenetic risk score (ERS) based on previously reported 144 alcohol-associated CpGs and examined the association of the ERS with systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension (HTN) in 3,898 Framingham Heart Study (FHS) participants. We found an association of alcohol intake with the ERS in the meta-analysis with 0.09 units higher ERS per drink consumed per day ( p < 0.0001). Cross-sectional analyses in FHS revealed that a one-unit increment of the ERS was associated with 1.93 mm Hg higher SBP ( p = 4.64E-07), 0.68 mm Hg higher DBP (p = 0.006), and an odds ratio of 1.78 for HTN ( p < 2E-16). Meta-analysis of the cross-sectional association of the ERS with BP traits in eight independent external cohorts (n = 11,544) showed similar relationships with blood pressure levels, i.e., a one-unit increase in ERS was associated with 0.74 ( p = 0.002) and 0.50 ( p = 0.0006) mm Hg higher SBP and DBP, but could not confirm the association with hypertension. Longitudinal analyses in FHS (n = 3,260) and five independent external cohorts (n = 4,021) showed that the baseline ERS was not associated with a change in blood pressure over time or with incident HTN.

CONCLUSIONS:

Our findings provide proof-of-concept that utilizing an ERS is a useful approach to capture the recent health consequences of lifestyle behaviors such as alcohol consumption.

Original language	English
Journal	Research Square
DOIs	https://doi.org/10.21203/rs.3.rs-4243866/v1
Publication status	Published - 19 Apr 2024

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Association analysis between an epigenetic alcoholFinal published version, 1.18 MBLicence: CC BY

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Bui, H., Keshawarz, A., Wang, M., Lee, M., Ratliff, S. M., Lin, L., Birditt, K. S., Faul, J. D., Peters, A., Gieger, C., Delerue, T., Kardia, S. L. R., Zhao, W., Guo, X., Yao, J., Rotter, J. I., Li, Y., Liu, X., Liu, D., ... Liu, C. (2024). Association analysis between an epigenetic risk score and blood pressure. Research Square. https://doi.org/10.21203/rs.3.rs-4243866/v1

@article{399927d783d14887a6bce6e2fa4e5f1a,

title = "Association analysis between an epigenetic risk score and blood pressure",

abstract = "BACKGROUND: Epigenome-wide association studies have revealed multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases.RESULTS: We generated an alcohol consumption epigenetic risk score (ERS) based on previously reported 144 alcohol-associated CpGs and examined the association of the ERS with systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension (HTN) in 3,898 Framingham Heart Study (FHS) participants. We found an association of alcohol intake with the ERS in the meta-analysis with 0.09 units higher ERS per drink consumed per day ( p < 0.0001). Cross-sectional analyses in FHS revealed that a one-unit increment of the ERS was associated with 1.93 mm Hg higher SBP ( p = 4.64E-07), 0.68 mm Hg higher DBP (p = 0.006), and an odds ratio of 1.78 for HTN ( p < 2E-16). Meta-analysis of the cross-sectional association of the ERS with BP traits in eight independent external cohorts (n = 11,544) showed similar relationships with blood pressure levels, i.e., a one-unit increase in ERS was associated with 0.74 ( p = 0.002) and 0.50 ( p = 0.0006) mm Hg higher SBP and DBP, but could not confirm the association with hypertension. Longitudinal analyses in FHS (n = 3,260) and five independent external cohorts (n = 4,021) showed that the baseline ERS was not associated with a change in blood pressure over time or with incident HTN. CONCLUSIONS: Our findings provide proof-of-concept that utilizing an ERS is a useful approach to capture the recent health consequences of lifestyle behaviors such as alcohol consumption.",

author = "Helena Bui and Amena Keshawarz and Mengyao Wang and Mikyeong Lee and Ratliff, {Scott M} and Lisha Lin and Birditt, {Kira S} and Faul, {Jessica D} and Annette Peters and Christian Gieger and Thomas Delerue and Kardia, {Sharon L R} and Wei Zhao and Xiuqing Guo and Jie Yao and Rotter, {Jerome I} and Yi Li and Xue Liu and Dan Liu and Tavares, {Juliana F} and G{\"o}khan Pehlivan and Breteler, {Monique M B} and Irma Karabegovic and Carolina Ochoa-Rosales and Trudy Voortman and Mohsen Ghanbari and {van Meurs}, {Joyce B J} and Nasr, {Mohamed Kamal} and Marcus D{\"o}rr and Grabe, {Hans J} and London, {Stephanie J} and Alexander Teumer and Melanie Waldenberger and Weir, {David R} and Smith, {Jennifer A} and Daniel Levy and Jiantao Ma and Chunyu Liu",

year = "2024",

month = apr,

day = "19",

doi = "10.21203/rs.3.rs-4243866/v1",

language = "English",

}

Bui, H, Keshawarz, A, Wang, M, Lee, M, Ratliff, SM, Lin, L, Birditt, KS, Faul, JD, Peters, A, Gieger, C, Delerue, T, Kardia, SLR, Zhao, W, Guo, X, Yao, J, Rotter, JI, Li, Y, Liu, X, Liu, D, Tavares, JF, Pehlivan, G, Breteler, MMB, Karabegovic, I, Ochoa-Rosales, C , Voortman, T , Ghanbari, M , van Meurs, JBJ, Nasr, MK, Dörr, M, Grabe, HJ, London, SJ, Teumer, A, Waldenberger, M, Weir, DR, Smith, JA, Levy, D, Ma, J & Liu, C 2024, 'Association analysis between an epigenetic risk score and blood pressure', Research Square. https://doi.org/10.21203/rs.3.rs-4243866/v1

TY - JOUR

T1 - Association analysis between an epigenetic risk score and blood pressure

AU - Bui, Helena

AU - Keshawarz, Amena

AU - Wang, Mengyao

AU - Lee, Mikyeong

AU - Ratliff, Scott M

AU - Lin, Lisha

AU - Birditt, Kira S

AU - Faul, Jessica D

AU - Peters, Annette

AU - Gieger, Christian

AU - Delerue, Thomas

AU - Kardia, Sharon L R

AU - Zhao, Wei

AU - Guo, Xiuqing

AU - Yao, Jie

AU - Rotter, Jerome I

AU - Li, Yi

AU - Liu, Xue

AU - Liu, Dan

AU - Tavares, Juliana F

AU - Pehlivan, Gökhan

AU - Breteler, Monique M B

AU - Karabegovic, Irma

AU - Ochoa-Rosales, Carolina

AU - Voortman, Trudy

AU - Ghanbari, Mohsen

AU - van Meurs, Joyce B J

AU - Nasr, Mohamed Kamal

AU - Dörr, Marcus

AU - Grabe, Hans J

AU - London, Stephanie J

AU - Teumer, Alexander

AU - Waldenberger, Melanie

AU - Weir, David R

AU - Smith, Jennifer A

AU - Levy, Daniel

AU - Ma, Jiantao

AU - Liu, Chunyu

PY - 2024/4/19

Y1 - 2024/4/19

N2 - BACKGROUND: Epigenome-wide association studies have revealed multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases.RESULTS: We generated an alcohol consumption epigenetic risk score (ERS) based on previously reported 144 alcohol-associated CpGs and examined the association of the ERS with systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension (HTN) in 3,898 Framingham Heart Study (FHS) participants. We found an association of alcohol intake with the ERS in the meta-analysis with 0.09 units higher ERS per drink consumed per day ( p < 0.0001). Cross-sectional analyses in FHS revealed that a one-unit increment of the ERS was associated with 1.93 mm Hg higher SBP ( p = 4.64E-07), 0.68 mm Hg higher DBP (p = 0.006), and an odds ratio of 1.78 for HTN ( p < 2E-16). Meta-analysis of the cross-sectional association of the ERS with BP traits in eight independent external cohorts (n = 11,544) showed similar relationships with blood pressure levels, i.e., a one-unit increase in ERS was associated with 0.74 ( p = 0.002) and 0.50 ( p = 0.0006) mm Hg higher SBP and DBP, but could not confirm the association with hypertension. Longitudinal analyses in FHS (n = 3,260) and five independent external cohorts (n = 4,021) showed that the baseline ERS was not associated with a change in blood pressure over time or with incident HTN. CONCLUSIONS: Our findings provide proof-of-concept that utilizing an ERS is a useful approach to capture the recent health consequences of lifestyle behaviors such as alcohol consumption.

AB - BACKGROUND: Epigenome-wide association studies have revealed multiple DNA methylation sites (CpGs) associated with alcohol consumption, an important lifestyle risk factor for cardiovascular diseases.RESULTS: We generated an alcohol consumption epigenetic risk score (ERS) based on previously reported 144 alcohol-associated CpGs and examined the association of the ERS with systolic blood pressure (SBP), diastolic blood pressure (DBP), and hypertension (HTN) in 3,898 Framingham Heart Study (FHS) participants. We found an association of alcohol intake with the ERS in the meta-analysis with 0.09 units higher ERS per drink consumed per day ( p < 0.0001). Cross-sectional analyses in FHS revealed that a one-unit increment of the ERS was associated with 1.93 mm Hg higher SBP ( p = 4.64E-07), 0.68 mm Hg higher DBP (p = 0.006), and an odds ratio of 1.78 for HTN ( p < 2E-16). Meta-analysis of the cross-sectional association of the ERS with BP traits in eight independent external cohorts (n = 11,544) showed similar relationships with blood pressure levels, i.e., a one-unit increase in ERS was associated with 0.74 ( p = 0.002) and 0.50 ( p = 0.0006) mm Hg higher SBP and DBP, but could not confirm the association with hypertension. Longitudinal analyses in FHS (n = 3,260) and five independent external cohorts (n = 4,021) showed that the baseline ERS was not associated with a change in blood pressure over time or with incident HTN. CONCLUSIONS: Our findings provide proof-of-concept that utilizing an ERS is a useful approach to capture the recent health consequences of lifestyle behaviors such as alcohol consumption.

U2 - 10.21203/rs.3.rs-4243866/v1

DO - 10.21203/rs.3.rs-4243866/v1

M3 - Article

C2 - 38699335

SN - 2693-5015

JO - Research Square

JF - Research Square

ER -

Association analysis between an epigenetic risk score and blood pressure

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