Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies

JM Murabito; CC White; Maryam Kavousi; YV Sun; MF Feitosa; V Nambi; C Lamina; A Schillert; S Coassin; JC Bis; Linda Broer; DC Crawford; N Franceschini; R Frikke-Schmidt; M Haun; S Holewijn; JE Huffman; SJ Hwang; S Kiechl; B Kollerits; ME Montasser; IM (Ilja) Nolte; ME Rudock; A Senft; A Teumer; P van der Harst; V Vitart; LL Waite; AR Wood; CL Wassel; DM Absher; MA Allison; Najaf Amin; A Arnold; FW Asselbergs; Yuriy Aulchenko; S Bandinelli; M Barbalic; M Boban; K Brown-Gentry; DJ Couper; MH Criqui; Abbas Dehghan; Mariska Heijer; B Dieplinger; JZ (Jing Zhong) Ding; M Dorr; C Espinola-Klein; SB Felix; L Ferrucci; AR Folsom; G Fraedrich; Q Gibson; R Goodloe; G Gunjaca; M Haltmayer; G Heiss; Bert Hofman; A Kieback; LA Kiemeney; I Kolcic; IJ Kullo; SB Kritchevsky; KJ Lackner; XH Li; WG Lieb; K Lohman; C Meisinger; D Melzer; ER Mohler; I Mudnic; T Mueller; G Navis; F Oberhollenzer; JW Olin; J O'Connell; CJ O'Donnell; W Palmas; BW Penninx; A Petersmann; O Polasek; BM Psaty; B Rantner; K Rice; Fernando Rivadeneira; JI Rotter; A Seldenrijk; M Stadler; M Summerer; T Tanaka; A Tybjaerg-Hansen; André Uitterlinden; WH van Gilst; SH Vermeulen; SH Wild; PS Wild; J Willeit; T Zeller; T Zemunik; L Zgaga; TL Assimes; S Blankenberg; E Boerwinkle; H Campbell; JP Cooke; J van der Graaf; D Herrington; SLR Kardia; BD Mitchell; A Murray; T Munzel; AB Newman; Ben Oostra; I Rudan; AR Shuldiner; H Snieder; Cornelia Duijn; U Volker; AF Wright; HE Wichmann; JF Wilson; JCM Witteman; YM Liu; C Hayward; IB Borecki; A Ziegler; KE North; LA Cupples; F Kronenberg

doi:10.1161/CIRCGENETICS.111.961292

Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies

JM Murabito, CC White, Maryam Kavousi, YV Sun, MF Feitosa, V Nambi, C Lamina, A Schillert, S Coassin, JC Bis, Linda Broer, DC Crawford, N Franceschini, R Frikke-Schmidt, M Haun, S Holewijn, JE Huffman, SJ Hwang, S Kiechl, B KolleritsME Montasser, IM (Ilja) Nolte, ME Rudock, A Senft, A Teumer, P van der Harst, V Vitart, LL Waite, AR Wood, CL Wassel, DM Absher, MA Allison, Najaf Amin, A Arnold, FW Asselbergs, Yuriy Aulchenko, S Bandinelli, M Barbalic, M Boban, K Brown-Gentry, DJ Couper, MH Criqui, Abbas Dehghan, Mariska Heijer, B Dieplinger, JZ (Jing Zhong) Ding, M Dorr, C Espinola-Klein, SB Felix, L Ferrucci, AR Folsom, G Fraedrich, Q Gibson, R Goodloe, G Gunjaca, M Haltmayer, G Heiss, Bert Hofman, A Kieback, LA Kiemeney, I Kolcic, IJ Kullo, SB Kritchevsky, KJ Lackner, XH Li, WG Lieb, K Lohman, C Meisinger, D Melzer, ER Mohler, I Mudnic, T Mueller, G Navis, F Oberhollenzer, JW Olin, J O'Connell, CJ O'Donnell, W Palmas, BW Penninx, A Petersmann, O Polasek, BM Psaty, B Rantner, K Rice, Fernando Rivadeneira, JI Rotter, A Seldenrijk, M Stadler, M Summerer, T Tanaka, A Tybjaerg-Hansen, André Uitterlinden, WH van Gilst, SH Vermeulen, SH Wild, PS Wild, J Willeit, T Zeller, T Zemunik, L Zgaga, TL Assimes, S Blankenberg, E Boerwinkle, H Campbell, JP Cooke, J van der Graaf, D Herrington, SLR Kardia, BD Mitchell, A Murray, T Munzel, AB Newman, Ben Oostra, I Rudan, AR Shuldiner, H Snieder, Cornelia Duijn, U Volker, AF Wright, HE Wichmann, JF Wilson, JCM Witteman, YM Liu, C Hayward, IB Borecki, A Ziegler, KE North, LA Cupples, F Kronenberg

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Abstract

Background-Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts. Methods and Results-Continuous ABI and PAD (ABI <= 0.9) phenotypes adjusted for age and sex were examined. Each study conducted genotyping and imputed data to the <= 2.5 million single nucleotide polymorphisms (SNPs) in HapMap. Linear and logistic regression models were used to test each SNP for association with ABI and PAD using additive genetic models. Study-specific data were combined using fixed effects inverse variance weighted meta-analyses. There were a total of 41 692 participants of Eur Conclusions-Genome-wide association studies in more than 40 000 individuals identified 1 genome wide significant association on chromosome 9p21 with ABI. Two candidate genes for PAD and 1 SNP for coronary artery disease are associated with ABI. (Circ Cardiovasc Genet. 2012;5:100-112.)

Original language	Undefined/Unknown
Pages (from-to)	100-112
Number of pages	13
Journal	Circulation-cardiovascular genetics
Volume	5
Issue number	1
DOIs	https://doi.org/10.1161/CIRCGENETICS.111.961292
Publication status	Published - 2012

Research programs

EMC MGC-02-96-01
EMC MM-01-39-09-A
EMC MM-04-42-02
EMC NIHES-01-64-01
EMC NIHES-01-64-02

Access to Document

10.1161/CIRCGENETICS.111.961292

http://hdl.handle.net/1765/71010

Cite this

Murabito, JM., White, CC., Kavousi, M., Sun, YV., Feitosa, MF., Nambi, V., Lamina, C., Schillert, A., Coassin, S., Bis, JC., Broer, L., Crawford, DC., Franceschini, N., Frikke-Schmidt, R., Haun, M., Holewijn, S., Huffman, JE., Hwang, SJ., Kiechl, S., ... Kronenberg, F. (2012). Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies. Circulation-cardiovascular genetics, 5(1), 100-112. https://doi.org/10.1161/CIRCGENETICS.111.961292

@article{9abd659e00ff4f13b7522016c8abe042,

title = "Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies",

abstract = "Background-Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts. Methods and Results-Continuous ABI and PAD (ABI <= 0.9) phenotypes adjusted for age and sex were examined. Each study conducted genotyping and imputed data to the <= 2.5 million single nucleotide polymorphisms (SNPs) in HapMap. Linear and logistic regression models were used to test each SNP for association with ABI and PAD using additive genetic models. Study-specific data were combined using fixed effects inverse variance weighted meta-analyses. There were a total of 41 692 participants of Eur Conclusions-Genome-wide association studies in more than 40 000 individuals identified 1 genome wide significant association on chromosome 9p21 with ABI. Two candidate genes for PAD and 1 SNP for coronary artery disease are associated with ABI. (Circ Cardiovasc Genet. 2012;5:100-112.)",

author = "JM Murabito and CC White and Maryam Kavousi and YV Sun and MF Feitosa and V Nambi and C Lamina and A Schillert and S Coassin and JC Bis and Linda Broer and DC Crawford and N Franceschini and R Frikke-Schmidt and M Haun and S Holewijn and JE Huffman and SJ Hwang and S Kiechl and B Kollerits and ME Montasser and Nolte, {IM (Ilja)} and ME Rudock and A Senft and A Teumer and {van der Harst}, P and V Vitart and LL Waite and AR Wood and CL Wassel and DM Absher and MA Allison and Najaf Amin and A Arnold and FW Asselbergs and Yuriy Aulchenko and S Bandinelli and M Barbalic and M Boban and K Brown-Gentry and DJ Couper and MH Criqui and Abbas Dehghan and Mariska Heijer and B Dieplinger and Ding, {JZ (Jing Zhong)} and M Dorr and C Espinola-Klein and SB Felix and L Ferrucci and AR Folsom and G Fraedrich and Q Gibson and R Goodloe and G Gunjaca and M Haltmayer and G Heiss and Bert Hofman and A Kieback and LA Kiemeney and I Kolcic and IJ Kullo and SB Kritchevsky and KJ Lackner and XH Li and WG Lieb and K Lohman and C Meisinger and D Melzer and ER Mohler and I Mudnic and T Mueller and G Navis and F Oberhollenzer and JW Olin and J O'Connell and CJ O'Donnell and W Palmas and BW Penninx and A Petersmann and O Polasek and BM Psaty and B Rantner and K Rice and Fernando Rivadeneira and JI Rotter and A Seldenrijk and M Stadler and M Summerer and T Tanaka and A Tybjaerg-Hansen and Andr{\'e} Uitterlinden and {van Gilst}, WH and SH Vermeulen and SH Wild and PS Wild and J Willeit and T Zeller and T Zemunik and L Zgaga and TL Assimes and S Blankenberg and E Boerwinkle and H Campbell and JP Cooke and {van der Graaf}, J and D Herrington and SLR Kardia and BD Mitchell and A Murray and T Munzel and AB Newman and Ben Oostra and I Rudan and AR Shuldiner and H Snieder and Cornelia Duijn and U Volker and AF Wright and HE Wichmann and JF Wilson and JCM Witteman and YM Liu and C Hayward and IB Borecki and A Ziegler and KE North and LA Cupples and F Kronenberg",

year = "2012",

doi = "10.1161/CIRCGENETICS.111.961292",

language = "Undefined/Unknown",

volume = "5",

pages = "100--112",

journal = "Circulation-cardiovascular genetics",

issn = "1942-325X",

publisher = "Lippincott Williams & Wilkins",

number = "1",

}

Murabito, JM, White, CC, Kavousi, M, Sun, YV, Feitosa, MF, Nambi, V, Lamina, C, Schillert, A, Coassin, S, Bis, JC, Broer, L, Crawford, DC, Franceschini, N, Frikke-Schmidt, R, Haun, M, Holewijn, S, Huffman, JE, Hwang, SJ, Kiechl, S, Kollerits, B, Montasser, ME, Nolte, IM, Rudock, ME, Senft, A, Teumer, A, van der Harst, P, Vitart, V, Waite, LL, Wood, AR, Wassel, CL, Absher, DM, Allison, MA, Amin, N, Arnold, A, Asselbergs, FW, Aulchenko, Y, Bandinelli, S, Barbalic, M, Boban, M, Brown-Gentry, K, Couper, DJ, Criqui, MH, Dehghan, A, Heijer, M, Dieplinger, B, Ding, JZ, Dorr, M, Espinola-Klein, C, Felix, SB, Ferrucci, L, Folsom, AR, Fraedrich, G, Gibson, Q, Goodloe, R, Gunjaca, G, Haltmayer, M, Heiss, G, Hofman, B, Kieback, A, Kiemeney, LA, Kolcic, I, Kullo, IJ, Kritchevsky, SB, Lackner, KJ, Li, XH, Lieb, WG, Lohman, K, Meisinger, C, Melzer, D, Mohler, ER, Mudnic, I, Mueller, T, Navis, G, Oberhollenzer, F, Olin, JW, O'Connell, J, O'Donnell, CJ, Palmas, W, Penninx, BW, Petersmann, A, Polasek, O, Psaty, BM, Rantner, B, Rice, K, Rivadeneira, F, Rotter, JI, Seldenrijk, A, Stadler, M, Summerer, M, Tanaka, T, Tybjaerg-Hansen, A, Uitterlinden, A, van Gilst, WH, Vermeulen, SH, Wild, SH, Wild, PS, Willeit, J, Zeller, T, Zemunik, T, Zgaga, L, Assimes, TL, Blankenberg, S, Boerwinkle, E, Campbell, H, Cooke, JP, van der Graaf, J, Herrington, D, Kardia, SLR, Mitchell, BD, Murray, A, Munzel, T, Newman, AB, Oostra, B, Rudan, I, Shuldiner, AR, Snieder, H, Duijn, C, Volker, U, Wright, AF, Wichmann, HE, Wilson, JF, Witteman, JCM, Liu, YM, Hayward, C, Borecki, IB, Ziegler, A, North, KE, Cupples, LA & Kronenberg, F 2012, 'Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies', Circulation-cardiovascular genetics, vol. 5, no. 1, pp. 100-112. https://doi.org/10.1161/CIRCGENETICS.111.961292

TY - JOUR

T1 - Association Between Chromosome 9p21 Variants and the Ankle-Brachial Index Identified by a Meta-Analysis of 21 Genome-Wide Association Studies

AU - Murabito, JM

AU - White, CC

AU - Kavousi, Maryam

AU - Sun, YV

AU - Feitosa, MF

AU - Nambi, V

AU - Lamina, C

AU - Schillert, A

AU - Coassin, S

AU - Bis, JC

AU - Broer, Linda

AU - Crawford, DC

AU - Franceschini, N

AU - Frikke-Schmidt, R

AU - Haun, M

AU - Holewijn, S

AU - Huffman, JE

AU - Hwang, SJ

AU - Kiechl, S

AU - Kollerits, B

AU - Montasser, ME

AU - Nolte, IM (Ilja)

AU - Rudock, ME

AU - Senft, A

AU - Teumer, A

AU - van der Harst, P

AU - Vitart, V

AU - Waite, LL

AU - Wood, AR

AU - Wassel, CL

AU - Absher, DM

AU - Allison, MA

AU - Amin, Najaf

AU - Arnold, A

AU - Asselbergs, FW

AU - Aulchenko, Yuriy

AU - Bandinelli, S

AU - Barbalic, M

AU - Boban, M

AU - Brown-Gentry, K

AU - Couper, DJ

AU - Criqui, MH

AU - Dehghan, Abbas

AU - Heijer, Mariska

AU - Dieplinger, B

AU - Ding, JZ (Jing Zhong)

AU - Dorr, M

AU - Espinola-Klein, C

AU - Felix, SB

AU - Ferrucci, L

AU - Folsom, AR

AU - Fraedrich, G

AU - Gibson, Q

AU - Goodloe, R

AU - Gunjaca, G

AU - Haltmayer, M

AU - Heiss, G

AU - Hofman, Bert

AU - Kieback, A

AU - Kiemeney, LA

AU - Kolcic, I

AU - Kullo, IJ

AU - Kritchevsky, SB

AU - Lackner, KJ

AU - Li, XH

AU - Lieb, WG

AU - Lohman, K

AU - Meisinger, C

AU - Melzer, D

AU - Mohler, ER

AU - Mudnic, I

AU - Mueller, T

AU - Navis, G

AU - Oberhollenzer, F

AU - Olin, JW

AU - O'Connell, J

AU - O'Donnell, CJ

AU - Palmas, W

AU - Penninx, BW

AU - Petersmann, A

AU - Polasek, O

AU - Psaty, BM

AU - Rantner, B

AU - Rice, K

AU - Rivadeneira, Fernando

AU - Rotter, JI

AU - Seldenrijk, A

AU - Stadler, M

AU - Summerer, M

AU - Tanaka, T

AU - Tybjaerg-Hansen, A

AU - Uitterlinden, André

AU - van Gilst, WH

AU - Vermeulen, SH

AU - Wild, SH

AU - Wild, PS

AU - Willeit, J

AU - Zeller, T

AU - Zemunik, T

AU - Zgaga, L

AU - Assimes, TL

AU - Blankenberg, S

AU - Boerwinkle, E

AU - Campbell, H

AU - Cooke, JP

AU - van der Graaf, J

AU - Herrington, D

AU - Kardia, SLR

AU - Mitchell, BD

AU - Murray, A

AU - Munzel, T

AU - Newman, AB

AU - Oostra, Ben

AU - Rudan, I

AU - Shuldiner, AR

AU - Snieder, H

AU - Duijn, Cornelia

AU - Volker, U

AU - Wright, AF

AU - Wichmann, HE

AU - Wilson, JF

AU - Witteman, JCM

AU - Liu, YM

AU - Hayward, C

AU - Borecki, IB

AU - Ziegler, A

AU - North, KE

AU - Cupples, LA

AU - Kronenberg, F

PY - 2012

Y1 - 2012

N2 - Background-Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts. Methods and Results-Continuous ABI and PAD (ABI <= 0.9) phenotypes adjusted for age and sex were examined. Each study conducted genotyping and imputed data to the <= 2.5 million single nucleotide polymorphisms (SNPs) in HapMap. Linear and logistic regression models were used to test each SNP for association with ABI and PAD using additive genetic models. Study-specific data were combined using fixed effects inverse variance weighted meta-analyses. There were a total of 41 692 participants of Eur Conclusions-Genome-wide association studies in more than 40 000 individuals identified 1 genome wide significant association on chromosome 9p21 with ABI. Two candidate genes for PAD and 1 SNP for coronary artery disease are associated with ABI. (Circ Cardiovasc Genet. 2012;5:100-112.)

AB - Background-Genetic determinants of peripheral arterial disease (PAD) remain largely unknown. To identify genetic variants associated with the ankle-brachial index (ABI), a noninvasive measure of PAD, we conducted a meta-analysis of genome-wide association study data from 21 population-based cohorts. Methods and Results-Continuous ABI and PAD (ABI <= 0.9) phenotypes adjusted for age and sex were examined. Each study conducted genotyping and imputed data to the <= 2.5 million single nucleotide polymorphisms (SNPs) in HapMap. Linear and logistic regression models were used to test each SNP for association with ABI and PAD using additive genetic models. Study-specific data were combined using fixed effects inverse variance weighted meta-analyses. There were a total of 41 692 participants of Eur Conclusions-Genome-wide association studies in more than 40 000 individuals identified 1 genome wide significant association on chromosome 9p21 with ABI. Two candidate genes for PAD and 1 SNP for coronary artery disease are associated with ABI. (Circ Cardiovasc Genet. 2012;5:100-112.)

U2 - 10.1161/CIRCGENETICS.111.961292

DO - 10.1161/CIRCGENETICS.111.961292

M3 - Article

C2 - 22199011

SN - 1942-325X

VL - 5

SP - 100

EP - 112

JO - Circulation-cardiovascular genetics

JF - Circulation-cardiovascular genetics

IS - 1

ER -