Association Between Population Density and Genetic Risk for Schizophrenia

LucÍa Colodro-Conde; Baptiste Couvy-Duchesne; John B. Whitfield; Fabian Streit; Scott Gordon; Kathryn E. Kemper; Loic Yengo; Zhili Zheng; Maciej Trzaskowski; Eveline L. Zeeuw; Michel G. Nivard; Marjolijn Das; Rachel E. Neale; Stuart Macgregor; Catherine M. Olsen; David C. Whiteman; Dorret I. Boomsma; Jian Yang; Marcella Rietschel; John J. McGrath; Sarah E. Medland; Nicholas G. Martin

doi:10.1001/jamapsychiatry.2018.1581

Association Between Population Density and Genetic Risk for Schizophrenia

LucÍa Colodro-Conde, Baptiste Couvy-Duchesne, John B. Whitfield, Fabian Streit, Scott Gordon, Kathryn E. Kemper, Loic Yengo, Zhili Zheng, Maciej Trzaskowski, Eveline L. Zeeuw, Michel G. Nivard, Marjolijn Das, Rachel E. Neale, Stuart Macgregor, Catherine M. Olsen, David C. Whiteman, Dorret I. Boomsma, Jian Yang, Marcella Rietschel, John J. McGrathSarah E. Medland, Nicholas G. Martin

Sociology

Research output: Contribution to journal › Article › Academic › peer-review

69 Citations (Scopus)

6 Downloads (Pure)

Abstract

Question Are adults with higher genetic risk for schizophrenia more likely to live in urbanized and populated areas than those with lower risk?
Findings In this cross-sectional study of 4 community-based samples from Australia, the United Kingdom, and the Netherlands, significantly higher genetic loading for schizophrenia was identified in participants living in more densely populated areas; mendelian randomization on a subsample suggests that schizophrenia may have a causal association with the tendency to live in urban areas.
Meaning The higher rates of schizophrenia in cities may be accentuated by selective migration to cities of participants with higher genetic risks.

Original language	English
Pages (from-to)	901-910
Number of pages	10
Journal	JAMA Psychiatry
Volume	75
Issue number	9
Early online date	23 Jun 2018
DOIs	https://doi.org/10.1001/jamapsychiatry.2018.1581
Publication status	Published - Sept 2018

Bibliographical note

Results of the study were presented at the 39th Annual Society for Mental Health Research Conference; December 6, 2017; Canberra, Australia.
This paper was presented at the 48th Behavior Genetics Annual Meeting; June 23, 2018; Boston, Massachusetts.

Research programs

ESSB SOC

Access to Document

10.1001/jamapsychiatry.2018.1581

Association Between Population Density and Genetic Risk for SchizophreniaFinal published version, 487 KBLicence: Article 25fa Dutch Copyright Act

http://hdl.handle.net/1765/112918

Cite this

Colodro-Conde, L., Couvy-Duchesne, B., Whitfield, J. B., Streit, F., Gordon, S., Kemper, K. E., Yengo, L., Zheng, Z., Trzaskowski, M., Zeeuw, E. L., Nivard, M. G., Das, M., Neale, R. E., Macgregor, S., Olsen, C. M., Whiteman, D. C., Boomsma, D. I., Yang, J., Rietschel, M., ... Martin, N. G. (2018). Association Between Population Density and Genetic Risk for Schizophrenia. JAMA Psychiatry, 75(9), 901-910. https://doi.org/10.1001/jamapsychiatry.2018.1581

@article{71273ff32b3541ba86081f88ea10acf1,

title = "Association Between Population Density and Genetic Risk for Schizophrenia",

abstract = "Question Are adults with higher genetic risk for schizophrenia more likely to live in urbanized and populated areas than those with lower risk?Findings In this cross-sectional study of 4 community-based samples from Australia, the United Kingdom, and the Netherlands, significantly higher genetic loading for schizophrenia was identified in participants living in more densely populated areas; mendelian randomization on a subsample suggests that schizophrenia may have a causal association with the tendency to live in urban areas.Meaning The higher rates of schizophrenia in cities may be accentuated by selective migration to cities of participants with higher genetic risks.",

author = "Luc{\'I}a Colodro-Conde and Baptiste Couvy-Duchesne and Whitfield, {John B.} and Fabian Streit and Scott Gordon and Kemper, {Kathryn E.} and Loic Yengo and Zhili Zheng and Maciej Trzaskowski and Zeeuw, {Eveline L.} and Nivard, {Michel G.} and Marjolijn Das and Neale, {Rachel E.} and Stuart Macgregor and Olsen, {Catherine M.} and Whiteman, {David C.} and Boomsma, {Dorret I.} and Jian Yang and Marcella Rietschel and McGrath, {John J.} and Medland, {Sarah E.} and Martin, {Nicholas G.}",

note = "Results of the study were presented at the 39th Annual Society for Mental Health Research Conference; December 6, 2017; Canberra, Australia. This paper was presented at the 48th Behavior Genetics Annual Meeting; June 23, 2018; Boston, Massachusetts.",

year = "2018",

month = sep,

doi = "10.1001/jamapsychiatry.2018.1581",

language = "English",

volume = "75",

pages = "901--910",

journal = "JAMA Psychiatry",

issn = "2168-622X",

publisher = "American Medical Association",

number = "9",

}

Colodro-Conde, L, Couvy-Duchesne, B, Whitfield, JB, Streit, F, Gordon, S, Kemper, KE, Yengo, L, Zheng, Z, Trzaskowski, M, Zeeuw, EL, Nivard, MG, Das, M, Neale, RE, Macgregor, S, Olsen, CM, Whiteman, DC, Boomsma, DI, Yang, J, Rietschel, M, McGrath, JJ, Medland, SE & Martin, NG 2018, 'Association Between Population Density and Genetic Risk for Schizophrenia', JAMA Psychiatry, vol. 75, no. 9, pp. 901-910. https://doi.org/10.1001/jamapsychiatry.2018.1581

TY - JOUR

T1 - Association Between Population Density and Genetic Risk for Schizophrenia

AU - Colodro-Conde, LucÍa

AU - Couvy-Duchesne, Baptiste

AU - Whitfield, John B.

AU - Streit, Fabian

AU - Gordon, Scott

AU - Kemper, Kathryn E.

AU - Yengo, Loic

AU - Zheng, Zhili

AU - Trzaskowski, Maciej

AU - Zeeuw, Eveline L.

AU - Nivard, Michel G.

AU - Das, Marjolijn

AU - Neale, Rachel E.

AU - Macgregor, Stuart

AU - Olsen, Catherine M.

AU - Whiteman, David C.

AU - Boomsma, Dorret I.

AU - Yang, Jian

AU - Rietschel, Marcella

AU - McGrath, John J.

AU - Medland, Sarah E.

AU - Martin, Nicholas G.

N1 - Results of the study were presented at the 39th Annual Society for Mental Health Research Conference; December 6, 2017; Canberra, Australia. This paper was presented at the 48th Behavior Genetics Annual Meeting; June 23, 2018; Boston, Massachusetts.

PY - 2018/9

Y1 - 2018/9

N2 - Question Are adults with higher genetic risk for schizophrenia more likely to live in urbanized and populated areas than those with lower risk?Findings In this cross-sectional study of 4 community-based samples from Australia, the United Kingdom, and the Netherlands, significantly higher genetic loading for schizophrenia was identified in participants living in more densely populated areas; mendelian randomization on a subsample suggests that schizophrenia may have a causal association with the tendency to live in urban areas.Meaning The higher rates of schizophrenia in cities may be accentuated by selective migration to cities of participants with higher genetic risks.

AB - Question Are adults with higher genetic risk for schizophrenia more likely to live in urbanized and populated areas than those with lower risk?Findings In this cross-sectional study of 4 community-based samples from Australia, the United Kingdom, and the Netherlands, significantly higher genetic loading for schizophrenia was identified in participants living in more densely populated areas; mendelian randomization on a subsample suggests that schizophrenia may have a causal association with the tendency to live in urban areas.Meaning The higher rates of schizophrenia in cities may be accentuated by selective migration to cities of participants with higher genetic risks.

U2 - 10.1001/jamapsychiatry.2018.1581

DO - 10.1001/jamapsychiatry.2018.1581

M3 - Article

C2 - 29936532

SN - 2168-622X

VL - 75

SP - 901

EP - 910

JO - JAMA Psychiatry

JF - JAMA Psychiatry

IS - 9

ER -

Association Between Population Density and Genetic Risk for Schizophrenia

Abstract

Bibliographical note

Research programs

Access to Document

Fingerprint

Cite this