Association between vitamin D receptor gene polymorphisms and type 1 diabetes mellitus in Iranian population

Zahra Mohammadnejad, Mohsen Ghanbari, Rashin Ganjali, Jalil Tavakkol Afshari, Mahyar Heydarpour, Seyed Morteza Taghavi, Sedigheh Fatemi, Houshang Rafatpanah*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

55 Citations (Scopus)

Abstract

Type 1 diabetes mellitus (T1DM) is one of the T-cell mediated autoimmune diseases and vitamin D suppresses activation of T-cell and has immunomodulatory effects. In this study the association between four vitamin D receptor (VDR) gene polymorphisms, at positions FokI, BsmI, ApaI and TaqI, and susceptibility to T1DM was investigated. We assessed 87 Iranian patients with T1DM and one hundred healthy controls with no history of diabetes or other autoimmune diseases. Our results demonstrated that genotypes frequency of the TaqI VDR polymorphism differed significantly between T1DM patients and controls, TT genotype and T allele was more frequent in healthy controls compared with TIDM patients (P = 0.003; OR = 0.51, 95% CI = 0.31-0.84). Therefore, allele t is the risk-allele for developing TIDM in this study. No significant association was observed between others VDR SNPs and disease susceptibility. In conclusion, our case-control study indicated that the VDR TaqI polymorphism is associated with TIDM in Iranian population.

Original languageEnglish
Pages (from-to)831-837
Number of pages7
JournalMolecular Biology Reports
Volume39
Issue number2
DOIs
Publication statusPublished - Feb 2012
Externally publishedYes

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