Association of body mass index and intestinal (faecal) Streptococcus in adults in Xining city, China P.R

M. Ma, J. Su, Y. Wang, L. Wang, Y. Li, G. Ding, Z. Ma, M. P. Peppelenbosch*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Abstract

Body mass index (BMI) and gut microbiota show significant interaction, but most studies on the relationship between BMI and gut microbiota have been done in Western countries. Relationships that are also identified in other cultural backgrounds are likely to have functional importance. Hence here we explore gut microbiota in adults living in Xining city (China P.R.) and relate results to subject BMI. Analysis of bacterial 16s rRNA gene was performed on faecal samples from participants with normal-weight (n=24), overweight (n=24), obesity (n=11) and type 2 diabetes (T2D) (n=8). The results show that unweighted but not weighted Unifrac distance was significantly different when gut microbiota composition was compared between the groups. Importantly, the genus Streptococcus was remarkably decreased in both obese subjects and subjects suffering from T2D, as compared to normal-weight subjects. Accordingly, strong association was identified between the genus Streptococcus and BMI and especially Streptococcus salivarius subsp. thermophiles was a major contributor in this respect. As previous studies have shown that Streptococcus salivarius subsp. thermophiles is also negatively associated with obesity in Western cohorts, our results suggest that this species is a potential probiotic for the prevention of obesity and related disorders.

Original languageEnglish
Pages (from-to)465-471
Number of pages7
JournalBeneficial microbes
Volume13
Issue number6
Early online date20 Oct 2022
DOIs
Publication statusPublished - 2022

Bibliographical note

Funding Information:
This study was supported by the Changjiang Scholars and Innovative Research Team in University (IRT_17R88) and Fundamental Research Funds for the Central Universities (31920180122).

Publisher Copyright:
© 2022 Wageningen Academic Publishers.

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