BACKGROUND: Body weight variability (BWV) refers to intraindividual weight loss and gain over a period. The association of long-term BWV with dementia remains unclear and whether this association is beyond body weight change is undetermined. METHODS: In the Health and Retirement Study, a total of 5 547 dementia-free participants (56.7% women; mean [SD] age, 71.1 [3.2] years) at baseline (2008) were followed up to 8 years (mean = 6.8 years) to detect incident dementia. Body weight was self-reported biennially from 1992 to 2008. BWV was measured as the coefficient of variation utilizing the body weight reported 9 times across 16 years before baseline. Cox-proportional hazard model was used to estimate the hazard ratio (HR) and 95% confidence interval (CI). RESULTS: Among the 5 547 participants, a total of 427 incident dementia cases were identified during follow-up. Greater long-term BWV was significantly associated with a higher risk of dementia (HR comparing extreme quartiles: 2.01, 95% CI: 1.48-2.72; HR of each SD increment: 1.21, 95% CI: 1.10-1.32; p-trend < .001) independent of mean body weight and body weight change. This significant association was even observed for BWV estimated approximately 15 years preceding dementia diagnosis (HR of each SD increment: 1.13, 95% CI: 1.03-1.23) and was more pronounced for that closer to diagnosis. CONCLUSION: Our prospective study suggested that greater BWV may be a novel risk factor for dementia.
|Number of pages||7|
|Journal||The journals of gerontology. Series A, Biological sciences and medical sciences|
|Publication status||Published - Oct 2022|
This work was supported by the Zhejiang University Education Foundation
Global Partnership Fund (to C.Y.). The Health and Retirement Study is sponsored
by the National Institute on Aging (NIA U01AG009740) and the Social Security
Administration. The study director is Dr. David R. Weir of the Survey Research
Center at the University of Michigan’s Institute for Social Research. The funding
organizations had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval
of the manuscript; and decision to submit the manuscript for publication.
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