Association study of copy number variants with brain volume in schizophrenia patients and healthy controls

Afke Terwisscha van Scheltinga*, Steven Bakker, Neeltje van Haren, Jacobine Buizer-Voskamp, Heleen Boos, Jacob Vorstman, Wiepke Cahn, Hilleke Hulshoff Pol, Roel Ophoff, René Kahn

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

7 Citations (Scopus)

Abstract

Schizophrenia patients have more copy number variations (CNVs) than healthy controls, and reduced brain volumes. Although this could suggest a causal relationship, we found no association between global CNV burden and three brain volume measures (on a MRI scan) in a sample of 173 schizophrenia patients and 176 healthy controls.

Original languageEnglish
Pages (from-to)1011-1013
Number of pages3
JournalPsychiatry Research
Volume200
Issue number2-3
DOIs
Publication statusPublished - 30 Dec 2012
Externally publishedYes

Bibliographical note

Funding Information:
We thank Thomas E. Gladwin and Flip Mulder for technical support. This work was supported by a Veni grant to SCB from Zorg Onderzoek Nederland, Medische Wetenschappen (ZON-MW, the Netherlands organization for health research and development , project number: 91686137 ) and by Top Institute Pharma (TI-Pharma, project T5-203). Genome-wide SNP genotyping was funded by the National Institute of Mental Health grant RO1 MG078075 to RAO.

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