TY - JOUR
T1 - Associations of relative fat mass, a new index of adiposity, with type-2 diabetes in the general population
AU - Suthahar, Navin
AU - Wang, Kan
AU - Zwartkruis, Victor W.
AU - Bakker, Stephan J.L.
AU - Inzucchi, Silvio E.
AU - Meems, Laura M.G.
AU - Eijgenraam, Tim R.
AU - Ahmadizar, Fariba
AU - Sijbrands, Eric G.
AU - Gansevoort, Ron． T.
AU - Kieneker, Lyanne M.
AU - van Veldhuisen, Dirk J.
AU - Kavousi, Maryam
AU - de Boer, Rudolf A.
N1 - Funding Information:
Drs. Suthahar, Zwartkruis and de Boer are supported by the Netherlands Heart Foundation (CVON SHE-PREDICTS-HF, grant 2017-21; CVON RED-CVD, grant 2017-11; CVON PREDICT2, grant 2018-30; and CVON DOUBLE DOSE, grant 2020B005), and Dr. de Boer also by a grant from the European Research Council (ERC CoG 818715, SECRETE-HF).
Publisher Copyright:
© 2022 The Author(s)
PY - 2023/3
Y1 - 2023/3
N2 - Background: Relative fat mass (RFM) is a novel sex-specific anthropometric equation (based on height and waist measurements) to estimate whole-body fat percentage. Objective: To examine associations of RFM with incident type-2 diabetes (T2D), and to benchmark its performance against body-mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR). Methods: This prospective longitudinal study included data from three Dutch community-based cohorts free of baseline diabetes. First, we examined data from the PREVEND cohort (median age and follow-up duration: 48.0 and 12.5 years, respectively) using Cox regression models. Validation was performed in the Lifelines (median age and follow-up duration: 45.5 and 3.8 years, respectively) and Rotterdam (median age and follow-up duration: 68.0 and 13.9 years, respectively) cohorts. Results: Among 7961 PREVEND participants, 522 (6.6%) developed T2D. In a multivariable model, all adiposity indices were significantly associated with incident T2D (P
all<0.001). While 1 SD increase in BMI, WC and WHR were associated with 68%, 77% and 61% increased risk of developing T2D [Hazard ratio (HR)
BMI: 1.68 (95%CI: 1.57-1.80), HR
WC: 1.77 (95% CI: 1.63-1.92) and HR
WHR: 1.61 (95%CI: 1.48-1.75)], an equivalent increase in RFM was associated with 119% increased risk [HR: 2.19 (95%CI: 1.96-2.44)]. RFM was associated with incident T2D across all age groups, with the largest effect size in the youngest (<40 years) age category [HR: 2.90 (95%CI: 2.15-3.92)]. Results were broadly similar in Lifelines (n = 93,870) and Rotterdam (n = 5279) cohorts. Conclusions: RFM is strongly associated with new-onset T2D and displays the potential to be used in the general practice setting to estimate the risk of future diabetes.
AB - Background: Relative fat mass (RFM) is a novel sex-specific anthropometric equation (based on height and waist measurements) to estimate whole-body fat percentage. Objective: To examine associations of RFM with incident type-2 diabetes (T2D), and to benchmark its performance against body-mass index (BMI), waist circumference (WC) and waist-to-hip ratio (WHR). Methods: This prospective longitudinal study included data from three Dutch community-based cohorts free of baseline diabetes. First, we examined data from the PREVEND cohort (median age and follow-up duration: 48.0 and 12.5 years, respectively) using Cox regression models. Validation was performed in the Lifelines (median age and follow-up duration: 45.5 and 3.8 years, respectively) and Rotterdam (median age and follow-up duration: 68.0 and 13.9 years, respectively) cohorts. Results: Among 7961 PREVEND participants, 522 (6.6%) developed T2D. In a multivariable model, all adiposity indices were significantly associated with incident T2D (P
all<0.001). While 1 SD increase in BMI, WC and WHR were associated with 68%, 77% and 61% increased risk of developing T2D [Hazard ratio (HR)
BMI: 1.68 (95%CI: 1.57-1.80), HR
WC: 1.77 (95% CI: 1.63-1.92) and HR
WHR: 1.61 (95%CI: 1.48-1.75)], an equivalent increase in RFM was associated with 119% increased risk [HR: 2.19 (95%CI: 1.96-2.44)]. RFM was associated with incident T2D across all age groups, with the largest effect size in the youngest (<40 years) age category [HR: 2.90 (95%CI: 2.15-3.92)]. Results were broadly similar in Lifelines (n = 93,870) and Rotterdam (n = 5279) cohorts. Conclusions: RFM is strongly associated with new-onset T2D and displays the potential to be used in the general practice setting to estimate the risk of future diabetes.
UR - http://www.scopus.com/inward/record.url?scp=85146020760&partnerID=8YFLogxK
U2 - 10.1016/j.ejim.2022.12.024
DO - 10.1016/j.ejim.2022.12.024
M3 - Article
C2 - 36604231
AN - SCOPUS:85146020760
SN - 0953-6205
VL - 109
SP - 73
EP - 78
JO - European Journal of Internal Medicine
JF - European Journal of Internal Medicine
ER -
