Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits

Bart Haagmans; Judith van den Brand; Lisette Provacia; Stalinraj Victor; Koert Stittelaar; Sarah Getu; Leon Waal; Theo Bestebroer; Geert Amerongen; Georges Verjans; Ron Fouchier; Saskia Smits; Thijs Kuiken; Ab Osterhaus

doi:10.1128/JVI.00661-15

Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits

Bart Haagmans, Judith van den Brand, Lisette Provacia, Stalinraj Victor, Koert Stittelaar, Sarah Getu, Leon Waal, Theo Bestebroer, Geert Amerongen, Georges Verjans, Ron Fouchier, Saskia Smits, Thijs Kuiken, Ab Osterhaus

Virology

Research output: Contribution to journal › Article › Academic › peer-review

72 Citations (Scopus)

Abstract

The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species.

Original language	Undefined/Unknown
Pages (from-to)	6131-6135
Number of pages	5
Journal	Journal of Virology
Volume	89
Issue number	11
DOIs	https://doi.org/10.1128/JVI.00661-15
Publication status	Published - 2015

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10.1128/JVI.00661-15

Cite this

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title = "Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits",

abstract = "The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species.",

author = "Bart Haagmans and {van den Brand}, Judith and Lisette Provacia and Stalinraj Victor and Koert Stittelaar and Sarah Getu and Leon Waal and Theo Bestebroer and Geert Amerongen and Georges Verjans and Ron Fouchier and Saskia Smits and Thijs Kuiken and Ab Osterhaus",

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T1 - Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits

AU - Haagmans, Bart

AU - van den Brand, Judith

AU - Provacia, Lisette

AU - Victor, Stalinraj

AU - Stittelaar, Koert

AU - Getu, Sarah

AU - Waal, Leon

AU - Bestebroer, Theo

AU - Amerongen, Geert

AU - Verjans, Georges

AU - Fouchier, Ron

AU - Smits, Saskia

AU - Kuiken, Thijs

AU - Osterhaus, Ab

PY - 2015

Y1 - 2015

N2 - The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species.

AB - The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species.

U2 - 10.1128/JVI.00661-15

DO - 10.1128/JVI.00661-15

M3 - Article

VL - 89

SP - 6131

EP - 6135

JO - Journal of Virology

JF - Journal of Virology

SN - 0022-538X

IS - 11

ER -