Asymptomatic Middle East Respiratory Syndrome Coronavirus Infection in Rabbits

Bart Haagmans, Judith van den Brand, Lisette Provacia, Stalinraj Victor, Koert Stittelaar, Sarah Getu, Leon Waal, Theo Bestebroer, Geert Amerongen, Georges Verjans, Ron Fouchier, Saskia Smits, Thijs Kuiken, Ab Osterhaus

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Abstract

The ability of Middle East respiratory syndrome coronavirus (MERS-CoV) to infect small animal species may be restricted given the fact that mice, ferrets, and hamsters were shown to resist MERS-CoV infection. We inoculated rabbits with MERS-CoV. Although virus was detected in the lungs, neither significant histopathological changes nor clinical symptoms were observed. Infectious virus, however, was excreted from the upper respiratory tract, indicating a potential route of MERS-CoV transmission in some animal species.
Original languageUndefined/Unknown
Pages (from-to)6131-6135
Number of pages5
JournalJournal of Virology
Volume89
Issue number11
DOIs
Publication statusPublished - 2015

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