ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes

AR Krebs, Jeroen Demmers, K Karmodiya, NC Chang, AC Chang, L Tora

Research output: Contribution to journalArticleAcademicpeer-review

40 Citations (Scopus)

Abstract

The Ada-Two-A-containing (ATAC) histone acetyltransferase and Mediator coactivator complexes regulate independent and distinct steps during transcription initiation and elongation. Here, we report the identification of a new stable molecular assembly formed between the ATAC and Mediator complexes in mouse embryonic stem cells. Moreover, we identify leucine zipper motif-containing protein 1 as a subunit of this meta-coactivator complex (MECO). Finally, we demonstrate that the MECO regulates a subset of RNA polymerase II-transcribed non-coding RNA genes. Our findings establish that transcription coactivator complexes can form stable subcomplexes to facilitate their combined actions on specific target genes.
Original languageUndefined/Unknown
Pages (from-to)541-547
Number of pages7
JournalEMBO Reports
Volume11
Issue number7
DOIs
Publication statusPublished - 2010

Research programs

  • EMC MGC-02-21-01

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