Atopic dermatitis: From monitoring to control

Research output: Types of ThesisDoctoral ThesisInternal

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Abstract

Atopic dermatitis (AD) is the most common inflammatory skin disorder, affecting the lives of many individuals and their families. In addition to a complex heterogeneous pathogenesis and clinical presentation, management of AD can be challenging. In the AD care pathway, many professionals interact with the same patient on multiple occasions, often over the course of several years. Although pivotal, current management of AD is poorly investigated. Understanding the challenges in the treatment of AD and opportunities to improve care remains therefore difficult.

Treatment of AD is based on three pillars: avoidance of irritants, strengthening of the skin barrier, and reducing inflammation. The ultimate goal of these strategies is to re-duce symptoms, improve quality of life, and achieve disease control. However, measuring these constructs in clinical practice and research can be challenging. Consequently, significant efforts have been made to establish a consensus-based core outcome set (COS) of well-validated measurement instruments for research and clinical practice. Nevertheless, several challenges remain present. For example, further validation of questionnaires set out to measure control in AD is needed as stakeholders including patients urged the need to include AD control as part of a COS. Next, as a potential intervention to achieve more control over AD, patients in the Netherlands have expressed a strong desire to investigate the role of antibacterial therapeutic clothing in AD. By reducing Staphylococcus aureus skin colonization, antibacterial therapeutic clothing aims to reduce AD symptoms and achieve more control. However, literature on the effectiveness of antibacterial therapeutic remains scarce and inconclusive.

The aim of this thesis was to 1) enhance understanding and evaluate potential barriers in the current AD management, 2) contribute to the development, validation, and enhancement of measurement instruments, and 3) assess the role of antibacterial clothing in AD.
Original languageEnglish
Supervisors/Advisors
  • Nijsten, Tamar, Supervisor
  • Schuttelaar, Marie louise, Supervisor
  • Schappin, Renske, Co-supervisor
Award date28 May 2024
Place of PublicationRotterdam
Publication statusPublished - 28 May 2024

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