Authors' response to Hogan

Bart L. Haagmans; Albert D.M.E. Osterhaus

doi:10.1371/journal.pmed.0030415

Authors' response to Hogan

Bart L. Haagmans^*
, Albert D.M.E. Osterhaus

^*Corresponding author for this work

Virology

Research output: Contribution to journal › Comment/Letter to the editor › Professional

23 Downloads (Pure)

Abstract

In response to our Perspective on nonhuman primate models for SARS, which accompanied the article by Lawler et al., Robert Hogan questions the usefulness of nonhuman primates as good models for SARS.

As demonstrated by several groups, SARS coronavirus (SARS-CoV) replicates to high titers in the respiratory tract of a surprisingly broad range of animal species, albeit showing remarkable differences in cell tropism. We have argued that efficient infection of type 1 and 2 pneumocytes as seen in macaques and humans—most likely due to the similarities in the spike protein binding domains of the host SARS-CoV receptor ACE2—is a prerequisite for the SARS-CoV infection–induced pathology observed in humans. So far there is no strong evidence that a similar tropism is observed in other animal species.

[...]

Original language	English
Pages (from-to)	1657-1658
Number of pages	2
Journal	PLoS Medicine
Volume	3
Issue number	9
DOIs	https://doi.org/10.1371/journal.pmed.0030415
Publication status	Published - 26 Sept 2006

Access to Document

10.1371/journal.pmed.0030415Licence: CC BY

Authors’ Response to HoganFinal published version, 76.2 KBLicence: CC BY

Cite this

@article{dbde7425d11d4ac4a3256a39adf86fdb,

title = "Authors' response to Hogan",

abstract = "In response to our Perspective on nonhuman primate models for SARS, which accompanied the article by Lawler et al., Robert Hogan questions the usefulness of nonhuman primates as good models for SARS. As demonstrated by several groups, SARS coronavirus (SARS-CoV) replicates to high titers in the respiratory tract of a surprisingly broad range of animal species, albeit showing remarkable differences in cell tropism. We have argued that efficient infection of type 1 and 2 pneumocytes as seen in macaques and humans—most likely due to the similarities in the spike protein binding domains of the host SARS-CoV receptor ACE2—is a prerequisite for the SARS-CoV infection–induced pathology observed in humans. So far there is no strong evidence that a similar tropism is observed in other animal species. [...]",

author = "Haagmans, \{Bart L.\} and Osterhaus, \{Albert D.M.E.\}",

year = "2006",

month = sep,

day = "26",

doi = "10.1371/journal.pmed.0030415",

language = "English",

volume = "3",

pages = "1657--1658",

journal = "PLoS Medicine",

issn = "1549-1277",

publisher = "Public Library of Science",

number = "9",

}

TY - JOUR

T1 - Authors' response to Hogan

AU - Haagmans, Bart L.

AU - Osterhaus, Albert D.M.E.

PY - 2006/9/26

Y1 - 2006/9/26

N2 - In response to our Perspective on nonhuman primate models for SARS, which accompanied the article by Lawler et al., Robert Hogan questions the usefulness of nonhuman primates as good models for SARS. As demonstrated by several groups, SARS coronavirus (SARS-CoV) replicates to high titers in the respiratory tract of a surprisingly broad range of animal species, albeit showing remarkable differences in cell tropism. We have argued that efficient infection of type 1 and 2 pneumocytes as seen in macaques and humans—most likely due to the similarities in the spike protein binding domains of the host SARS-CoV receptor ACE2—is a prerequisite for the SARS-CoV infection–induced pathology observed in humans. So far there is no strong evidence that a similar tropism is observed in other animal species. [...]

AB - In response to our Perspective on nonhuman primate models for SARS, which accompanied the article by Lawler et al., Robert Hogan questions the usefulness of nonhuman primates as good models for SARS. As demonstrated by several groups, SARS coronavirus (SARS-CoV) replicates to high titers in the respiratory tract of a surprisingly broad range of animal species, albeit showing remarkable differences in cell tropism. We have argued that efficient infection of type 1 and 2 pneumocytes as seen in macaques and humans—most likely due to the similarities in the spike protein binding domains of the host SARS-CoV receptor ACE2—is a prerequisite for the SARS-CoV infection–induced pathology observed in humans. So far there is no strong evidence that a similar tropism is observed in other animal species. [...]

UR - https://www.scopus.com/pages/publications/33749024474

U2 - 10.1371/journal.pmed.0030415

DO - 10.1371/journal.pmed.0030415

M3 - Comment/Letter to the editor

AN - SCOPUS:33749024474

SN - 1549-1277

VL - 3

SP - 1657

EP - 1658

JO - PLoS Medicine

JF - PLoS Medicine

IS - 9

ER -

Authors' response to Hogan

Abstract

Access to Document

Other files and links

Fingerprint

Nonhuman primate models for SARS

Cite this