Autoantibodies in Sjögren's syndrome and its classification criteria

Sharon Veenbergen*, Ana Kozmar, Paul L.A. van Daele, Marco W.J. Schreurs

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

21 Citations (Scopus)
134 Downloads (Pure)

Abstract

Sjögren's syndrome (SS) is a systemic autoimmune disease characterized by immune-mediated injury of exocrine glands. Extensive lymphocytic infiltrates may contribute to the destruction and loss of secretory function of glands. B-cell hyperactivity is a key feature of the disease resulting in the production of a diverse array of autoantibodies in these patients. Although not specific for SS, anti-Ro/SSA and anti-La/SSB antibodies have been useful biomarkers for disease classification and diagnosis. During recent years, novel autoantibodies have been discovered in SS. In this review, we summarize the historical role and clinical relevance that autoantibodies have played in the classification criteria of Sjögren's syndrome, discuss laboratory aspects in antibody detection and review the role of novel autoantibodies in predicting particular stages of the disease, clinical phenotypes and long-term complications.

Original languageEnglish
Article number100138
JournalJournal of Translational Autoimmunity
Volume5
Early online date27 Dec 2021
DOIs
Publication statusPublished - Jan 2022

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