Automatic lipid detection in human coronary atherosclerosis using spectroscopic intravascular photoacoustic imaging

Krista Jansen; Antonius Fw Van Der Steen; Heleen Mm Van Beusekom; Geert Springeling; Min Wu; Frits Mastik; Gijs Van Soest

doi:10.1109/ULTSYM.2012.0009

Automatic lipid detection in human coronary atherosclerosis using spectroscopic intravascular photoacoustic imaging

Krista Jansen, Antonius Fw Van Der Steen, Heleen Mm Van Beusekom, Geert Springeling, Min Wu, Frits Mastik, Gijs Van Soest

Cardiology

Research output: Chapter/Conference proceeding › Conference proceeding › Academic › peer-review

2 Citations (Scopus)

Abstract

Lipid content is a key factor in vulnerable atherosclerotic plaques that may lead to myocardial infarction. Intravascular photoacoustic (IVPA) imaging is a possible method to identify lipid content in the artery wall. We developed a method to automatically detect lipids in human coronary atherosclerosis using spectroscopic IVPA. In cross-sectional IVPA/intravascular ultrasound (IVUS) scans of fresh ex vivo human coronary arteries, we correlated the photoacoustic spectra to a reference lipid spectrum in the 1200 nm spectral range. Correlation coeffcients above a certain cut-off value indicated similarity between IVPA and reference lipid spectra. Automatically detected lipid areas exhibited good correspondence with the histological lipid stain of the same cross section.

Original language	English
Title of host publication	2012 IEEE International Ultrasonics Symposium, IUS 2012
Pages	32-35
Number of pages	4
DOIs	https://doi.org/10.1109/ULTSYM.2012.0009
Publication status	Published - 2012
Event	2012 IEEE International Ultrasonics Symposium, IUS 2012 - Dresden, Germany Duration: 7 Oct 2012 → 10 Oct 2012

Publication series

Series	IEEE International Ultrasonics Symposium, IUS
ISSN	1948-5719

Conference

Conference	2012 IEEE International Ultrasonics Symposium, IUS 2012
Country/Territory	Germany
City	Dresden
Period	7/10/12 → 10/10/12

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10.1109/ULTSYM.2012.0009

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title = "Automatic lipid detection in human coronary atherosclerosis using spectroscopic intravascular photoacoustic imaging",

abstract = "Lipid content is a key factor in vulnerable atherosclerotic plaques that may lead to myocardial infarction. Intravascular photoacoustic (IVPA) imaging is a possible method to identify lipid content in the artery wall. We developed a method to automatically detect lipids in human coronary atherosclerosis using spectroscopic IVPA. In cross-sectional IVPA/intravascular ultrasound (IVUS) scans of fresh ex vivo human coronary arteries, we correlated the photoacoustic spectra to a reference lipid spectrum in the 1200 nm spectral range. Correlation coeffcients above a certain cut-off value indicated similarity between IVPA and reference lipid spectra. Automatically detected lipid areas exhibited good correspondence with the histological lipid stain of the same cross section.",

author = "Krista Jansen and {Van Der Steen}, {Antonius Fw} and {Van Beusekom}, {Heleen Mm} and Geert Springeling and Min Wu and Frits Mastik and {Van Soest}, Gijs",

year = "2012",

doi = "10.1109/ULTSYM.2012.0009",

language = "English",

isbn = "9781467345613",

series = "IEEE International Ultrasonics Symposium, IUS",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

pages = "32--35",

booktitle = "2012 IEEE International Ultrasonics Symposium, IUS 2012",

note = "2012 IEEE International Ultrasonics Symposium, IUS 2012 ; Conference date: 07-10-2012 Through 10-10-2012",

}

Jansen, K, Van Der Steen, AF , Van Beusekom, HM, Springeling, G, Wu, M, Mastik, F & Van Soest, G 2012, Automatic lipid detection in human coronary atherosclerosis using spectroscopic intravascular photoacoustic imaging. in 2012 IEEE International Ultrasonics Symposium, IUS 2012., 6562032, IEEE International Ultrasonics Symposium, IUS, pp. 32-35, 2012 IEEE International Ultrasonics Symposium, IUS 2012, Dresden, Germany, 7/10/12. https://doi.org/10.1109/ULTSYM.2012.0009

Automatic lipid detection in human coronary atherosclerosis using spectroscopic intravascular photoacoustic imaging. / Jansen, Krista; Van Der Steen, Antonius Fw ; Van Beusekom, Heleen Mm et al.
2012 IEEE International Ultrasonics Symposium, IUS 2012. 2012. p. 32-35 6562032 (IEEE International Ultrasonics Symposium, IUS).

Research output: Chapter/Conference proceeding › Conference proceeding › Academic › peer-review

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T1 - Automatic lipid detection in human coronary atherosclerosis using spectroscopic intravascular photoacoustic imaging

AU - Jansen, Krista

AU - Van Der Steen, Antonius Fw

AU - Van Beusekom, Heleen Mm

AU - Springeling, Geert

AU - Wu, Min

AU - Mastik, Frits

AU - Van Soest, Gijs

PY - 2012

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N2 - Lipid content is a key factor in vulnerable atherosclerotic plaques that may lead to myocardial infarction. Intravascular photoacoustic (IVPA) imaging is a possible method to identify lipid content in the artery wall. We developed a method to automatically detect lipids in human coronary atherosclerosis using spectroscopic IVPA. In cross-sectional IVPA/intravascular ultrasound (IVUS) scans of fresh ex vivo human coronary arteries, we correlated the photoacoustic spectra to a reference lipid spectrum in the 1200 nm spectral range. Correlation coeffcients above a certain cut-off value indicated similarity between IVPA and reference lipid spectra. Automatically detected lipid areas exhibited good correspondence with the histological lipid stain of the same cross section.

AB - Lipid content is a key factor in vulnerable atherosclerotic plaques that may lead to myocardial infarction. Intravascular photoacoustic (IVPA) imaging is a possible method to identify lipid content in the artery wall. We developed a method to automatically detect lipids in human coronary atherosclerosis using spectroscopic IVPA. In cross-sectional IVPA/intravascular ultrasound (IVUS) scans of fresh ex vivo human coronary arteries, we correlated the photoacoustic spectra to a reference lipid spectrum in the 1200 nm spectral range. Correlation coeffcients above a certain cut-off value indicated similarity between IVPA and reference lipid spectra. Automatically detected lipid areas exhibited good correspondence with the histological lipid stain of the same cross section.

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T3 - IEEE International Ultrasonics Symposium, IUS

SP - 32

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BT - 2012 IEEE International Ultrasonics Symposium, IUS 2012

T2 - 2012 IEEE International Ultrasonics Symposium, IUS 2012

Y2 - 7 October 2012 through 10 October 2012

ER -

Automatic lipid detection in human coronary atherosclerosis using spectroscopic intravascular photoacoustic imaging

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