Automatic scan range for dose-reduced multiphase CT imaging of the liver utilizing CNNs and Gaussian models

Manh Ha Luu*, Theo van Walsum, Hong Son Mai, Daniel Franklin, Thi Thu Thao Nguyen, Thi My Le, Adriaan Moelker, Van Khang Le, Dang Luu Vu, Ngoc Ha Le, Quoc Long Tran, Duc Trinh Chu, Nguyen Linh Trung

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

1 Citation (Scopus)

Abstract

Multiphase CT scanning of the liver is performed for several clinical applications; however, radiation exposure from CT scanning poses a nontrivial cancer risk to the patients. The radiation dose may be reduced by determining the scan range of the subsequent scans by the location of the target of interest in the first scan phase. The purpose of this study is to present and assess an automatic method for determining the scan range for multiphase CT scans. Our strategy is to first apply a CNN-based method for detecting the liver in 2D slices, and to use a liver range search algorithm for detecting the liver range in the scout volume. The target liver scan range for subsequent scans can be obtained by adding safety margins achieved from Gaussian liver motion models to the scan range determined from the scout. Experiments were performed on 657 multiphase CT volumes obtained from multiple hospitals. The experiment shows that the proposed liver detection method can detect the liver in 223 out of a total of 224 3D volumes on average within one second, with mean intersection of union, wall distance and centroid distance of 85.5%, 5.7 mm and 9.7 mm, respectively. In addition, the performance of the proposed liver detection method is comparable to the best of the state-of-the-art 3D liver detectors in the liver detection accuracy while it requires less processing time. Furthermore, we apply the liver scan range generation method on the liver CT images acquired from radiofrequency ablation and Y-90 transarterial radioembolization (selective internal radiation therapy) interventions of 46 patients from two hospitals. The result shows that the automatic scan range generation can significantly reduce the effective radiation dose by an average of 14.5% (2.56 mSv) compared to manual performance by the radiographer from Y-90 transarterial radioembolization, while no statistically significant difference in performance was found with the CT images from intra RFA intervention (p = 0.81). Finally, three radiologists assess both the original and the range-reduced images for evaluating the effect of the range reduction method on their clinical decisions. We conclude that the automatic liver scan range generation method is able to reduce excess radiation compared to the manual performance with a high accuracy and without penalizing the clinical decision.

Original languageEnglish
Article number102422
JournalMedical Image Analysis
Volume78
DOIs
Publication statusPublished - May 2022

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 102.01-2018.316 . We would like to thank Mayo Clinic for sharing the CT images. We also would like to thank NVIDA corporation for supporting a GPU RTX 8000 for this study. We would like to thank Mr. Le Quoc Anh for the technical assistance, and specially would like to thank Prof. Huynh Huu Tue for the counseling in the research.

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 102.01-2018.316. We would like to thank Mayo Clinic for sharing the CT images. We also would like to thank NVIDA corporation for supporting a GPU RTX 8000 for this study. We would like to thank Mr. Le Quoc Anh for the technical assistance, and specially would like to thank Prof. Huynh Huu Tue for the counseling in the research.

Publisher Copyright:
© 2022 Elsevier B.V.

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