Automatic Segmentation of the Optic Nerve Head Region in Optical Coherence Tomography: A Methodological Review

Rita Marques, Danilo Andrade De Jesus*, João Barbosa-Breda, Jan Van Eijgen, Ingeborg Stalmans, Theo van Walsum, Stefan Klein, Pedro G. Vaz, Luisa Sánchez Brea

*Corresponding author for this work

Research output: Contribution to journalReview articlePopular

2 Citations (Scopus)
1 Downloads (Pure)

Abstract

The optic nerve head (ONH) represents the intraocular section of the optic nerve, which is prone to damage by intraocular pressure (IOP). The advent of optical coherence tomography (OCT) has enabled the evaluation of novel ONH parameters, namely the depth and curvature of the lamina cribrosa (LC). Together with the Bruch's membrane minimum-rim-width (BMO-MRW), these seem to be promising ONH parameters for diagnosis and monitoring of retinal diseases such as glaucoma. Nonetheless, these OCT derived biomarkers are mostly extracted through manual segmentation, which is time-consuming and prone to bias, thus limiting their usability in clinical practice. The automatic segmentation of ONH in OCT scans could further improve the current clinical management of glaucoma and other diseases. This review summarizes the current state-of-the-art in automatic segmentation of the ONH in OCT. PubMed and Scopus were used to perform a systematic review. Additional works from other databases (IEEE, Google Scholar and ARVO IOVS) were also included, resulting in a total of 29 reviewed studies. For each algorithm, the methods, the size and type of dataset used for validation, and the respective results were carefully analysed. The results show a lack of consensus regarding the definition of segmented regions, extracted parameters and validation approaches, highlighting the importance and need of standardized methodologies for ONH segmentation. Only with a concrete set of guidelines, these automatic segmentation algorithms will build trust in data-driven segmentation models and be able to enter clinical practice.

Original languageEnglish
Article number106801
JournalComputer Methods and Programs in Biomedicine
Volume220
Early online date13 Apr 2022
DOIs
Publication statusPublished - Jun 2022

Bibliographical note

Funding Information:
This work was supported by the Horizon 2020 Research and Innovation Programme (grant agreement no. 780989: Multi-modal, multi-scale retinal imaging project) and by Portuguese National Funds through the FCT, FundaȺo Para a CiȬncia e a Tecnologia, I.P., in the scope of the project UIDB/04559/2020.

Funding Information:
This work was supported by the Horizon 2020 Research and Innovation Programme (grant agreement no. 780989: Multi-modal, multi-scale retinal imaging project) and by Portuguese National Funds through the FCT, Funda?o Para a Ci?ncia e a Tecnologia, I.P. in the scope of the project UIDB/04559/2020.

Publisher Copyright:
© 2022 Elsevier B.V.

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