Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model

G. M. de Jong; X. Z. Yap; J. Walk; W. A. Dik; M. B.B. McCall; P. J.J. van Genderen; J. J. van Hellemond; A. Verbon; R. W. Sauerwein

doi:10.1016/j.imlet.2023.04.005

Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model

G. M. de Jong, X. Z. Yap, J. Walk, W. A. Dik, M. B.B. McCall, P. J.J. van Genderen, J. J. van Hellemond, A. Verbon, R. W. Sauerwein^*

^*Corresponding author for this work

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Abstract

Background: Here we assessed a possible relationship between baseline TGF-β concentrations and acquisition of sterile immunity after Plasmodium falciparum sporozoite immunization. Methods: TGF-β concentrations were determined in samples of 65 malaria-naive volunteers in 4 studies either prior to and after challenge infection, or prior to and after first immunizing infection under chemoprophylaxis with P. falciparum sporozoites. Results: High baseline TGF-β concentrations were associated with rapid acquisition of sterile protection (p = 0.028). Conclusion: Baseline TGF-β concentrations predict the efficiency of acquisition of sterile immunity following sporozoite immunization and may represent a steady-state regulatory mechanism to keep in check immune systems with a low threshold for activation.

Original language	English
Pages (from-to)	20-23
Number of pages	4
Journal	Immunology Letters
Volume	258
DOIs	https://doi.org/10.1016/j.imlet.2023.04.005
Publication status	Published - Jun 2023

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1-s2.0-S0165247823000561-mainFinal published version, 771 KBLicence: CC BY

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de Jong, G. M., Yap, X. Z., Walk, J., Dik, W. A., McCall, M. B. B., van Genderen, P. J. J., van Hellemond, J. J., Verbon, A., & Sauerwein, R. W. (2023). Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model. Immunology Letters, 258, 20-23. https://doi.org/10.1016/j.imlet.2023.04.005

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title = "Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model",

abstract = "Background: Here we assessed a possible relationship between baseline TGF-β concentrations and acquisition of sterile immunity after Plasmodium falciparum sporozoite immunization. Methods: TGF-β concentrations were determined in samples of 65 malaria-naive volunteers in 4 studies either prior to and after challenge infection, or prior to and after first immunizing infection under chemoprophylaxis with P. falciparum sporozoites. Results: High baseline TGF-β concentrations were associated with rapid acquisition of sterile protection (p = 0.028). Conclusion: Baseline TGF-β concentrations predict the efficiency of acquisition of sterile immunity following sporozoite immunization and may represent a steady-state regulatory mechanism to keep in check immune systems with a low threshold for activation.",

author = "{de Jong}, {G. M.} and Yap, {X. Z.} and J. Walk and Dik, {W. A.} and McCall, {M. B.B.} and {van Genderen}, {P. J.J.} and {van Hellemond}, {J. J.} and A. Verbon and Sauerwein, {R. W.}",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = jun,

doi = "10.1016/j.imlet.2023.04.005",

language = "English",

volume = "258",

pages = "20--23",

journal = "Immunology Letters",

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T1 - Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model

AU - de Jong, G. M.

AU - Yap, X. Z.

AU - Walk, J.

AU - Dik, W. A.

AU - McCall, M. B.B.

AU - van Genderen, P. J.J.

AU - van Hellemond, J. J.

AU - Verbon, A.

AU - Sauerwein, R. W.

PY - 2023/6

Y1 - 2023/6

N2 - Background: Here we assessed a possible relationship between baseline TGF-β concentrations and acquisition of sterile immunity after Plasmodium falciparum sporozoite immunization. Methods: TGF-β concentrations were determined in samples of 65 malaria-naive volunteers in 4 studies either prior to and after challenge infection, or prior to and after first immunizing infection under chemoprophylaxis with P. falciparum sporozoites. Results: High baseline TGF-β concentrations were associated with rapid acquisition of sterile protection (p = 0.028). Conclusion: Baseline TGF-β concentrations predict the efficiency of acquisition of sterile immunity following sporozoite immunization and may represent a steady-state regulatory mechanism to keep in check immune systems with a low threshold for activation.

AB - Background: Here we assessed a possible relationship between baseline TGF-β concentrations and acquisition of sterile immunity after Plasmodium falciparum sporozoite immunization. Methods: TGF-β concentrations were determined in samples of 65 malaria-naive volunteers in 4 studies either prior to and after challenge infection, or prior to and after first immunizing infection under chemoprophylaxis with P. falciparum sporozoites. Results: High baseline TGF-β concentrations were associated with rapid acquisition of sterile protection (p = 0.028). Conclusion: Baseline TGF-β concentrations predict the efficiency of acquisition of sterile immunity following sporozoite immunization and may represent a steady-state regulatory mechanism to keep in check immune systems with a low threshold for activation.

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U2 - 10.1016/j.imlet.2023.04.005

DO - 10.1016/j.imlet.2023.04.005

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AN - SCOPUS:85158054942

SN - 0165-2478

VL - 258

SP - 20

EP - 23

JO - Immunology Letters

JF - Immunology Letters

ER -

Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model

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