Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model

G. M. de Jong; X. Z. Yap; J. Walk; W. A. Dik; M. B.B. McCall; P. J.J. van Genderen; J. J. van Hellemond; A. Verbon; R. W. Sauerwein

doi:10.1016/j.imlet.2023.04.005

Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model

G. M. de Jong
, X. Z. Yap
, J. Walk
, W. A. Dik
, M. B.B. McCall
, P. J.J. van Genderen
, J. J. van Hellemond
, A. Verbon
, R. W. Sauerwein^*

^*Corresponding author for this work

Radboud University Medical Center

Research output: Contribution to journal › Article › Academic › peer-review

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Abstract

Background: Here we assessed a possible relationship between baseline TGF-β concentrations and acquisition of sterile immunity after Plasmodium falciparum sporozoite immunization. Methods: TGF-β concentrations were determined in samples of 65 malaria-naive volunteers in 4 studies either prior to and after challenge infection, or prior to and after first immunizing infection under chemoprophylaxis with P. falciparum sporozoites. Results: High baseline TGF-β concentrations were associated with rapid acquisition of sterile protection (p = 0.028). Conclusion: Baseline TGF-β concentrations predict the efficiency of acquisition of sterile immunity following sporozoite immunization and may represent a steady-state regulatory mechanism to keep in check immune systems with a low threshold for activation.

Original language	English
Pages (from-to)	20-23
Number of pages	4
Journal	Immunology Letters
Volume	258
DOIs	https://doi.org/10.1016/j.imlet.2023.04.005
Publication status	Published - Jun 2023

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10.1016/j.imlet.2023.04.005

1-s2.0-S0165247823000561-mainFinal published version, 771 KBLicence: CC BY

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de Jong, G. M., Yap, X. Z., Walk, J., Dik, W. A., McCall, M. B. B., van Genderen, P. J. J., van Hellemond, J. J., Verbon, A., & Sauerwein, R. W. (2023). Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model. Immunology Letters, 258, 20-23. https://doi.org/10.1016/j.imlet.2023.04.005

@article{975b08b237bb4834acdbd459e5a63d7b,

title = "Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model",

abstract = "Background: Here we assessed a possible relationship between baseline TGF-β concentrations and acquisition of sterile immunity after Plasmodium falciparum sporozoite immunization. Methods: TGF-β concentrations were determined in samples of 65 malaria-naive volunteers in 4 studies either prior to and after challenge infection, or prior to and after first immunizing infection under chemoprophylaxis with P. falciparum sporozoites. Results: High baseline TGF-β concentrations were associated with rapid acquisition of sterile protection (p = 0.028). Conclusion: Baseline TGF-β concentrations predict the efficiency of acquisition of sterile immunity following sporozoite immunization and may represent a steady-state regulatory mechanism to keep in check immune systems with a low threshold for activation.",

author = "\{de Jong\}, \{G. M.\} and Yap, \{X. Z.\} and J. Walk and Dik, \{W. A.\} and McCall, \{M. B.B.\} and \{van Genderen\}, \{P. J.J.\} and \{van Hellemond\}, \{J. J.\} and A. Verbon and Sauerwein, \{R. W.\}",

note = "Publisher Copyright: {\textcopyright} 2023",

year = "2023",

month = jun,

doi = "10.1016/j.imlet.2023.04.005",

language = "English",

volume = "258",

pages = "20--23",

journal = "Immunology Letters",

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TY - JOUR

T1 - Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model

AU - de Jong, G. M.

AU - Yap, X. Z.

AU - Walk, J.

AU - Dik, W. A.

AU - McCall, M. B.B.

AU - van Genderen, P. J.J.

AU - van Hellemond, J. J.

AU - Verbon, A.

AU - Sauerwein, R. W.

PY - 2023/6

Y1 - 2023/6

N2 - Background: Here we assessed a possible relationship between baseline TGF-β concentrations and acquisition of sterile immunity after Plasmodium falciparum sporozoite immunization. Methods: TGF-β concentrations were determined in samples of 65 malaria-naive volunteers in 4 studies either prior to and after challenge infection, or prior to and after first immunizing infection under chemoprophylaxis with P. falciparum sporozoites. Results: High baseline TGF-β concentrations were associated with rapid acquisition of sterile protection (p = 0.028). Conclusion: Baseline TGF-β concentrations predict the efficiency of acquisition of sterile immunity following sporozoite immunization and may represent a steady-state regulatory mechanism to keep in check immune systems with a low threshold for activation.

AB - Background: Here we assessed a possible relationship between baseline TGF-β concentrations and acquisition of sterile immunity after Plasmodium falciparum sporozoite immunization. Methods: TGF-β concentrations were determined in samples of 65 malaria-naive volunteers in 4 studies either prior to and after challenge infection, or prior to and after first immunizing infection under chemoprophylaxis with P. falciparum sporozoites. Results: High baseline TGF-β concentrations were associated with rapid acquisition of sterile protection (p = 0.028). Conclusion: Baseline TGF-β concentrations predict the efficiency of acquisition of sterile immunity following sporozoite immunization and may represent a steady-state regulatory mechanism to keep in check immune systems with a low threshold for activation.

UR - https://www.scopus.com/pages/publications/85158054942

U2 - 10.1016/j.imlet.2023.04.005

DO - 10.1016/j.imlet.2023.04.005

M3 - Article

C2 - 37075916

AN - SCOPUS:85158054942

SN - 0165-2478

VL - 258

SP - 20

EP - 23

JO - Immunology Letters

JF - Immunology Letters

ER -

Baseline TGF-β correlates with protection after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model

Abstract

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