TY - JOUR
T1 - Benefit of adjuvant chemotherapy on recurrence free survival per consensus molecular subtype in stage III colon cancer
AU - van de Weerd, Simone
AU - Torang, Arezo
AU - van den Berg, Inge
AU - Lammers, Veerle
AU - van den Bergh, Saskia
AU - Brouwer, Nelleke
AU - Nagtegaal, Iris D.
AU - Koopman, Miriam
AU - Vink, Geraldine R.
AU - van der Baan, Frederieke H.
AU - van Krieken, Han
AU - Koster, Jan
AU - Ijzermans, Jan N.
AU - Roodhart, Jeanine M. L.
AU - Medema, Jan Paul
N1 - Publisher Copyright:
© 2024 The Author(s). International Journal of Cancer published by John Wiley & Sons Ltd on behalf of UICC.
PY - 2024/8/8
Y1 - 2024/8/8
N2 - The consensus molecular subtype (CMS) classification divides colon tumors into four subtypes holding promise as a predictive biomarker. However, the effect of adjuvant chemotherapy on recurrence free survival (RFS) per CMS in stage III patients remains inadequately explored. With this intention, we selected stage III colon cancer (CC) patients from the MATCH cohort (n = 575) and RadboudUMC (n = 276) diagnosed between 2005 and 2018. Patients treated with and without adjuvant chemotherapy were matched based on tumor location, T- and N-stage (n = 522). Tumor material was available for 464 patients, with successful RNA extraction and CMS subtyping achieved in 390 patients (surgery alone group: 192, adjuvant chemotherapy group: 198). In the overall cohort, CMS4 was associated with poorest prognosis (HR 1.55; p =.03). Multivariate analysis revealed favorable RFS for the adjuvant chemotherapy group in CMS1, CMS2, and CMS4 tumors (HR 0.19; p =.01, HR 0.27; p <.01, HR 0.19; p <.01, respectively), while no significant difference between treatment groups was observed within CMS3 (HR 0.68; p =.51). CMS subtyping in this non-randomized cohort identified patients with poor prognosis and patients who may not benefit significantly from adjuvant chemotherapy.
AB - The consensus molecular subtype (CMS) classification divides colon tumors into four subtypes holding promise as a predictive biomarker. However, the effect of adjuvant chemotherapy on recurrence free survival (RFS) per CMS in stage III patients remains inadequately explored. With this intention, we selected stage III colon cancer (CC) patients from the MATCH cohort (n = 575) and RadboudUMC (n = 276) diagnosed between 2005 and 2018. Patients treated with and without adjuvant chemotherapy were matched based on tumor location, T- and N-stage (n = 522). Tumor material was available for 464 patients, with successful RNA extraction and CMS subtyping achieved in 390 patients (surgery alone group: 192, adjuvant chemotherapy group: 198). In the overall cohort, CMS4 was associated with poorest prognosis (HR 1.55; p =.03). Multivariate analysis revealed favorable RFS for the adjuvant chemotherapy group in CMS1, CMS2, and CMS4 tumors (HR 0.19; p =.01, HR 0.27; p <.01, HR 0.19; p <.01, respectively), while no significant difference between treatment groups was observed within CMS3 (HR 0.68; p =.51). CMS subtyping in this non-randomized cohort identified patients with poor prognosis and patients who may not benefit significantly from adjuvant chemotherapy.
UR - http://www.scopus.com/inward/record.url?scp=85200974315&partnerID=8YFLogxK
U2 - 10.1002/ijc.35120
DO - 10.1002/ijc.35120
M3 - Article
C2 - 39115332
SN - 0020-7136
VL - 156
SP - 456
EP - 466
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 2
ER -
