Bergmann Glial AMPA Receptors Are Required for Fine Motor Coordination

AS Saab, A Neumeyer, HM Jahn, Alexander Cupido, AAM Simek, Henk-jan Boele, A Scheller, K Le Meur, M Gotz, H Monyer, R Sprengel, ME Rubio, JW Deitmer, Chris de Zeeuw, F Kirchhoff

Research output: Contribution to journalArticleAcademicpeer-review

124 Citations (Scopus)

Abstract

The impact of glial neurotransmitter receptors in vivo is still elusive. In the cerebellum, Bergmann glial (BG) cells express alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors (AMPARs) composed exclusively of GluA1 and/or GluA4 subunits. With the use of conditional gene inactivation, we found that the majority of cerebellar GluA1/A4-type AMPARs are expressed in BG cells. In young mice, deletion of BG AMPARs resulted in retraction of glial appendages from Purkinje cell (PC) synapses, increased amplitude and duration of evoked PC currents, and a delayed formation of glutamatergic synapses. In adult mice, AMPAR inactivation also caused retraction of glial processes. The physiological and structural changes were accompanied by behavioral impairments in fine motor coordination. Thus, BG AMPARs are essential to optimize synaptic integration and cerebellar output function throughout life.
Original languageUndefined/Unknown
Pages (from-to)749-753
Number of pages5
JournalScience
Volume337
Issue number6095
DOIs
Publication statusPublished - 2012

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