beta CaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses

Geeske van Woerden; Freek Hoebeek; ZY Gao; RY Nagaraja; CC Hoogenraad; Steven Kushner; Christian Hansel; Chris de Zeeuw; Ype Elgersma

doi:10.1038/nn.2329

beta CaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses

Geeske van Woerden, Freek Hoebeek, ZY Gao, RY Nagaraja, CC Hoogenraad, Steven Kushner, Christian Hansel, Chris de Zeeuw, Ype Elgersma

Research output: Contribution to journal › Article › Academic › peer-review

106 Citations (Scopus)

Abstract

We found that beta CaMKII, the predominant CaMKII isoform of the cerebellum, is important for controlling the direction of plasticity at the parallel fiber-Purkinje cell synapse; a protocol that induced synaptic depression in wild-type mice resulted in synaptic potentiation in Camk2b knockout mice and vice versa. These findings provide us with unique experimental insight into the mechanisms that transduce graded calcium signals into either synaptic depression or potentiation.

Original language	Undefined/Unknown
Pages (from-to)	823-825
Number of pages	3
Journal	Nature Neuroscience
Volume	12
Issue number	7
DOIs	https://doi.org/10.1038/nn.2329
Publication status	Published - 2009

Research programs

EMC ONWAR-01-94-01
EMC OR-01-58-01

Access to Document

10.1038/nn.2329

http://hdl.handle.net/1765/22573

Cite this

@article{de1cc47541734a509980917bfd675705,

title = "beta CaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses",

abstract = "We found that beta CaMKII, the predominant CaMKII isoform of the cerebellum, is important for controlling the direction of plasticity at the parallel fiber-Purkinje cell synapse; a protocol that induced synaptic depression in wild-type mice resulted in synaptic potentiation in Camk2b knockout mice and vice versa. These findings provide us with unique experimental insight into the mechanisms that transduce graded calcium signals into either synaptic depression or potentiation.",

author = "{van Woerden}, Geeske and Freek Hoebeek and ZY Gao and RY Nagaraja and CC Hoogenraad and Steven Kushner and Christian Hansel and {de Zeeuw}, Chris and Ype Elgersma",

year = "2009",

doi = "10.1038/nn.2329",

language = "Undefined/Unknown",

volume = "12",

pages = "823--825",

journal = "Nature Neuroscience",

issn = "1097-6256",

publisher = "Nature Research",

number = "7",

}

TY - JOUR

T1 - beta CaMKII controls the direction of plasticity at parallel fiber-Purkinje cell synapses

AU - van Woerden, Geeske

AU - Hoebeek, Freek

AU - Gao, ZY

AU - Nagaraja, RY

AU - Hoogenraad, CC

AU - Kushner, Steven

AU - Hansel, Christian

AU - de Zeeuw, Chris

AU - Elgersma, Ype

PY - 2009

Y1 - 2009

N2 - We found that beta CaMKII, the predominant CaMKII isoform of the cerebellum, is important for controlling the direction of plasticity at the parallel fiber-Purkinje cell synapse; a protocol that induced synaptic depression in wild-type mice resulted in synaptic potentiation in Camk2b knockout mice and vice versa. These findings provide us with unique experimental insight into the mechanisms that transduce graded calcium signals into either synaptic depression or potentiation.

AB - We found that beta CaMKII, the predominant CaMKII isoform of the cerebellum, is important for controlling the direction of plasticity at the parallel fiber-Purkinje cell synapse; a protocol that induced synaptic depression in wild-type mice resulted in synaptic potentiation in Camk2b knockout mice and vice versa. These findings provide us with unique experimental insight into the mechanisms that transduce graded calcium signals into either synaptic depression or potentiation.

U2 - 10.1038/nn.2329

DO - 10.1038/nn.2329

M3 - Article

SN - 1097-6256

VL - 12

SP - 823

EP - 825

JO - Nature Neuroscience

JF - Nature Neuroscience

IS - 7

ER -