beta-Glucan exacerbates allergic airway responses to house dust mite allergen

S Hadebe, F Kirstein, K Fierens, P Redelinghuys, GI Murray, DL Williams, Bart Lambrecht, F Brombacher, GD Brown

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Abstract

beta-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. beta-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified beta-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Der beta T cells). We therefore provide definitive evidence that beta-glucan can influence allergic pulmonary inflammation.
Original languageUndefined/Unknown
JournalRespiratory Research
Volume17
DOIs
Publication statusPublished - 2016

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