beta-Glucan exacerbates allergic airway responses to house dust mite allergen

S Hadebe; F Kirstein; K Fierens; P Redelinghuys; GI Murray; DL Williams; Bart Lambrecht; F Brombacher; GD Brown

doi:10.1186/s12931-016-0352-5

beta-Glucan exacerbates allergic airway responses to house dust mite allergen

S Hadebe, F Kirstein, K Fierens, P Redelinghuys, GI Murray, DL Williams, Bart Lambrecht, F Brombacher, GD Brown

Pulmonary Medicine

Research output: Contribution to journal › Article › Academic › peer-review

7 Citations (Scopus)

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Abstract

beta-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. beta-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified beta-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Der beta T cells). We therefore provide definitive evidence that beta-glucan can influence allergic pulmonary inflammation.

Original language	Undefined/Unknown
Journal	Respiratory Research
Volume	17
DOIs	https://doi.org/10.1186/s12931-016-0352-5
Publication status	Published - 2016

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10.1186/s12931-016-0352-5

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Cite this

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title = "beta-Glucan exacerbates allergic airway responses to house dust mite allergen",

abstract = "beta-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. beta-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified beta-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Der beta T cells). We therefore provide definitive evidence that beta-glucan can influence allergic pulmonary inflammation.",

author = "S Hadebe and F Kirstein and K Fierens and P Redelinghuys and GI Murray and DL Williams and Bart Lambrecht and F Brombacher and GD Brown",

year = "2016",

doi = "10.1186/s12931-016-0352-5",

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volume = "17",

journal = "Respiratory Research",

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TY - JOUR

T1 - beta-Glucan exacerbates allergic airway responses to house dust mite allergen

AU - Hadebe, S

AU - Kirstein, F

AU - Fierens, K

AU - Redelinghuys, P

AU - Murray, GI

AU - Williams, DL

AU - Lambrecht, Bart

AU - Brombacher, F

AU - Brown, GD

PY - 2016

Y1 - 2016

N2 - beta-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. beta-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified beta-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Der beta T cells). We therefore provide definitive evidence that beta-glucan can influence allergic pulmonary inflammation.

AB - beta-(1,3)-Glucan is present in mould cell walls and frequently detected in house dust mite (HDM) faeces. beta-Glucan exposure is thought to be associated with pulmonary allergic inflammation in mouse and man, although the published data are inconsistent. Here, we show that highly purified beta-glucan exacerbates HDM-induced eosinophilic, T helper 2 type airway responses by acting as an adjuvant, promoting activation, proliferation and polarisation of HDM-specific T cells (1-Der beta T cells). We therefore provide definitive evidence that beta-glucan can influence allergic pulmonary inflammation.

U2 - 10.1186/s12931-016-0352-5

DO - 10.1186/s12931-016-0352-5

M3 - Article

VL - 17

JO - Respiratory Research

JF - Respiratory Research

SN - 1465-9921

ER -