TY - JOUR
T1 - Bias in the measurement of the outcome is associated with effect sizes in randomized clinical trials on exercise therapy for chronic low back pain
T2 - a meta-epidemiological study
AU - Innocenti, Tiziano
AU - Hayden, Jill A
AU - Salvioli, Stefano
AU - Giagio, Silvia
AU - Piano, Leonardo
AU - Cosentino, Carola
AU - Brindisino, Fabrizio
AU - Feller, Daniel
AU - Ogilvie, Rachel
AU - Gianola, Silvia
AU - Castellini, Greta
AU - Bargeri, Silvia
AU - Twisk, Jos Wr
AU - Ostelo, Raymond W
AU - Chiarotto, Alessandro
N1 - Publisher Copyright: © 2023 The Author(s)
PY - 2023/10
Y1 - 2023/10
N2 - Objectives: To explore the relationships between the risk of bias and treatment effect estimates for exercise therapy interventions on pain intensity and physical functioning outcomes in randomized controlled trials (RCTs) involving patients with chronic low back pain. Study Design and Setting: A cross-sectional meta-epidemiological study of the 230 RCTs (31,674 participants) in the 2021 ‘Exercise therapy for chronic low back pain’ Cochrane Review were included. Study design characteristics, sample size, prospective trial registration, flowchart information, interventions, and comparisons were extracted. Independent pairs of reviewers assessed the risk of bias using the Cochrane Risk of Bias 2 tool. Results: The metaregression included 220 (pain intensity) and 203 (physical functioning) effect sizes. Unadjusted and adjusted metaregression models showed no significant associations between the bias domains and pain intensity effect sizes. Only domain ‘bias in the measurement of the outcome’ was significantly associated with physical functioning (standardized mean difference: −0.40, 95% confidence interval: −0.77 to −0.02) when adjusted for flowchart reported (yes/no), prospective trial registration, sample size, and comparator type. Conclusion: The risk of bias in the measurement of the outcome could lead to slight overestimates of the effect size for physical functioning. Clinicians should consider this when they read and assess RCT results in this field. We encourage metaresearchers to replicate our findings using a consistent approach for evaluating the risk of bias (i.e., the RoB 2 tool) in other musculoskeletal conditions and interventions to investigate their generalizability.
AB - Objectives: To explore the relationships between the risk of bias and treatment effect estimates for exercise therapy interventions on pain intensity and physical functioning outcomes in randomized controlled trials (RCTs) involving patients with chronic low back pain. Study Design and Setting: A cross-sectional meta-epidemiological study of the 230 RCTs (31,674 participants) in the 2021 ‘Exercise therapy for chronic low back pain’ Cochrane Review were included. Study design characteristics, sample size, prospective trial registration, flowchart information, interventions, and comparisons were extracted. Independent pairs of reviewers assessed the risk of bias using the Cochrane Risk of Bias 2 tool. Results: The metaregression included 220 (pain intensity) and 203 (physical functioning) effect sizes. Unadjusted and adjusted metaregression models showed no significant associations between the bias domains and pain intensity effect sizes. Only domain ‘bias in the measurement of the outcome’ was significantly associated with physical functioning (standardized mean difference: −0.40, 95% confidence interval: −0.77 to −0.02) when adjusted for flowchart reported (yes/no), prospective trial registration, sample size, and comparator type. Conclusion: The risk of bias in the measurement of the outcome could lead to slight overestimates of the effect size for physical functioning. Clinicians should consider this when they read and assess RCT results in this field. We encourage metaresearchers to replicate our findings using a consistent approach for evaluating the risk of bias (i.e., the RoB 2 tool) in other musculoskeletal conditions and interventions to investigate their generalizability.
UR - http://www.scopus.com/inward/record.url?scp=85172285038&partnerID=8YFLogxK
U2 - 10.1016/j.jclinepi.2023.09.001
DO - 10.1016/j.jclinepi.2023.09.001
M3 - Review article
C2 - 37704114
SN - 0895-4356
VL - 162
SP - 145
EP - 155
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
ER -