Bias in the measurement of the outcome is associated with effect sizes in randomized clinical trials on exercise therapy for chronic low back pain: a meta-epidemiological study

Tiziano Innocenti*, Jill A Hayden, Stefano Salvioli, Silvia Giagio, Leonardo Piano, Carola Cosentino, Fabrizio Brindisino, Daniel Feller, Rachel Ogilvie, Silvia Gianola, Greta Castellini, Silvia Bargeri, Jos Wr Twisk, Raymond W Ostelo, Alessandro Chiarotto

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

2 Citations (Scopus)

Abstract

Objectives: To explore the relationships between the risk of bias and treatment effect estimates for exercise therapy interventions on pain intensity and physical functioning outcomes in randomized controlled trials (RCTs) involving patients with chronic low back pain. Study Design and Setting: A cross-sectional meta-epidemiological study of the 230 RCTs (31,674 participants) in the 2021 ‘Exercise therapy for chronic low back pain’ Cochrane Review were included. Study design characteristics, sample size, prospective trial registration, flowchart information, interventions, and comparisons were extracted. Independent pairs of reviewers assessed the risk of bias using the Cochrane Risk of Bias 2 tool. Results: The metaregression included 220 (pain intensity) and 203 (physical functioning) effect sizes. Unadjusted and adjusted metaregression models showed no significant associations between the bias domains and pain intensity effect sizes. Only domain ‘bias in the measurement of the outcome’ was significantly associated with physical functioning (standardized mean difference: −0.40, 95% confidence interval: −0.77 to −0.02) when adjusted for flowchart reported (yes/no), prospective trial registration, sample size, and comparator type. Conclusion: The risk of bias in the measurement of the outcome could lead to slight overestimates of the effect size for physical functioning. Clinicians should consider this when they read and assess RCT results in this field. We encourage metaresearchers to replicate our findings using a consistent approach for evaluating the risk of bias (i.e., the RoB 2 tool) in other musculoskeletal conditions and interventions to investigate their generalizability.

Original languageEnglish
Pages (from-to)145-155
Number of pages11
JournalJournal of Clinical Epidemiology
Volume162
Early online date12 Sept 2023
DOIs
Publication statusPublished - Oct 2023

Bibliographical note

Publisher Copyright: © 2023 The Author(s)

Fingerprint

Dive into the research topics of 'Bias in the measurement of the outcome is associated with effect sizes in randomized clinical trials on exercise therapy for chronic low back pain: a meta-epidemiological study'. Together they form a unique fingerprint.

Cite this