Biodegradable polymeric microcapsules for selective ultrasound-triggered drug release

D Lensen, EC Gelderblom, DM Vriezema, P Marmottant, N Verdonschot, M Versluis, Nico Jong, JCM van Hest

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Abstract

A series of hollow biodegradable polymeric microcapsules were prepared, of which their susceptibility to ultrasound was used for triggered release. High speed imaging of the ultrasound experiments showed a strong correlation between the acoustic pressure needed to activate these microcapsules and their shell thickness to diameter ratio. Based on this information a selective triggering of capsules with two different shell thickness to diameter ratios was successfully performed. The capsules were mixed in a single system and were activated independently from each other by a differentiation in acoustic pressure levels. This application is of great interest in the field of drug delivery, since this system allows for localized multiple drug releases in a selective fashion.
Original languageUndefined/Unknown
Pages (from-to)5417-5422
Number of pages6
JournalSoft Matter
Volume7
Issue number11
DOIs
Publication statusPublished - 2011

Research programs

  • EMC COEUR-09

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