Biodegradable poly(polyol sebacate) polymers

Joost Bruggeman; BJ de Bruin; CJ Bettinger; R Langer

doi:10.1016/j.biomaterials.2008.08.037

Biodegradable poly(polyol sebacate) polymers

Joost Bruggeman, BJ de Bruin, CJ Bettinger, R Langer

Research output: Contribution to journal › Article › Academic › peer-review

207 Citations (Scopus)

Abstract

We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. These thermoset networks exhibited tensile Young's modiali ranging from 0.37 +/- 0.08 to 378 +/- 33 MPa with maximum elongations at break from 10.90 +/- 1.37% to 205.16 +/- 55.76%, and glass transition temperatures ranging from similar to 7-46 degrees C. In vitro degradation under physiological conditions was slower than in vivo degradation rates observed for some PPS polymers. PPS polymers demonstrated similar in vitro and in vivo biocompatibility compared to poly(L-lactic-co-glycolic acid) (PLGA). (c) 2008 Elsevier Ltd. All rights reserved.

Original language	Undefined/Unknown
Pages (from-to)	4726-4735
Number of pages	10
Journal	Biomaterials
Volume	29
Issue number	36
DOIs	https://doi.org/10.1016/j.biomaterials.2008.08.037
Publication status	Published - 2008
Externally published	Yes

Research programs

EMC MUSC-01-50-01

Access to Document

10.1016/j.biomaterials.2008.08.037

http://hdl.handle.net/1765/14634

Cite this

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title = "Biodegradable poly(polyol sebacate) polymers",

abstract = "We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. These thermoset networks exhibited tensile Young's modiali ranging from 0.37 +/- 0.08 to 378 +/- 33 MPa with maximum elongations at break from 10.90 +/- 1.37% to 205.16 +/- 55.76%, and glass transition temperatures ranging from similar to 7-46 degrees C. In vitro degradation under physiological conditions was slower than in vivo degradation rates observed for some PPS polymers. PPS polymers demonstrated similar in vitro and in vivo biocompatibility compared to poly(L-lactic-co-glycolic acid) (PLGA). (c) 2008 Elsevier Ltd. All rights reserved.",

author = "Joost Bruggeman and {de Bruin}, BJ and CJ Bettinger and R Langer",

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TY - JOUR

T1 - Biodegradable poly(polyol sebacate) polymers

AU - Bruggeman, Joost

AU - de Bruin, BJ

AU - Bettinger, CJ

AU - Langer, R

PY - 2008

Y1 - 2008

N2 - We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. These thermoset networks exhibited tensile Young's modiali ranging from 0.37 +/- 0.08 to 378 +/- 33 MPa with maximum elongations at break from 10.90 +/- 1.37% to 205.16 +/- 55.76%, and glass transition temperatures ranging from similar to 7-46 degrees C. In vitro degradation under physiological conditions was slower than in vivo degradation rates observed for some PPS polymers. PPS polymers demonstrated similar in vitro and in vivo biocompatibility compared to poly(L-lactic-co-glycolic acid) (PLGA). (c) 2008 Elsevier Ltd. All rights reserved.

AB - We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. These thermoset networks exhibited tensile Young's modiali ranging from 0.37 +/- 0.08 to 378 +/- 33 MPa with maximum elongations at break from 10.90 +/- 1.37% to 205.16 +/- 55.76%, and glass transition temperatures ranging from similar to 7-46 degrees C. In vitro degradation under physiological conditions was slower than in vivo degradation rates observed for some PPS polymers. PPS polymers demonstrated similar in vitro and in vivo biocompatibility compared to poly(L-lactic-co-glycolic acid) (PLGA). (c) 2008 Elsevier Ltd. All rights reserved.

U2 - 10.1016/j.biomaterials.2008.08.037

DO - 10.1016/j.biomaterials.2008.08.037

M3 - Article

C2 - 18824260

SN - 0142-9612

VL - 29

SP - 4726

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JO - Biomaterials

JF - Biomaterials

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