Biodegradable poly(polyol sebacate) polymers

Joost P. Bruggeman; Berend-Jan de Bruin; Christopher J. Bettinger; Robert Langer

doi:10.1016/j.biomaterials.2008.08.037

Biodegradable poly(polyol sebacate) polymers

Joost P. Bruggeman
, Berend-Jan de Bruin
, Christopher J. Bettinger
, Robert Langer

Plastic and Reconstructive Surgery and Hand Surgery

Massachusetts Institute of Technology
Erasmus University Medical Centre
Charles Stark Draper Laboratory

Research output: Contribution to journal › Article › Academic › peer-review

217 Citations (Scopus)

Abstract

We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. These thermoset networks exhibited tensile Young's modiali ranging from 0.37 +/- 0.08 to 378 +/- 33 MPa with maximum elongations at break from 10.90 +/- 1.37% to 205.16 +/- 55.76%, and glass transition temperatures ranging from similar to ∼7-46 degrees C. In vitro degradation under physiological conditions was slower than in vivo degradation rates observed for some PPS polymers. PPS polymers demonstrated similar in vitro and in vivo biocompatibility compared to poly(_L-lactic-co-glycolic acid) (PLGA).

Original language	English
Pages (from-to)	4726-4735
Number of pages	10
Journal	Biomaterials
Volume	29
Issue number	36
DOIs	https://doi.org/10.1016/j.biomaterials.2008.08.037
Publication status	Published - Dec 2008

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10.1016/j.biomaterials.2008.08.037

http://hdl.handle.net/1765/14634

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title = "Biodegradable poly(polyol sebacate) polymers",

abstract = "We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. These thermoset networks exhibited tensile Young's modiali ranging from 0.37 +/- 0.08 to 378 +/- 33 MPa with maximum elongations at break from 10.90 +/- 1.37\% to 205.16 +/- 55.76\%, and glass transition temperatures ranging from similar to ∼7-46 degrees C. In vitro degradation under physiological conditions was slower than in vivo degradation rates observed for some PPS polymers. PPS polymers demonstrated similar in vitro and in vivo biocompatibility compared to poly(L-lactic-co-glycolic acid) (PLGA).",

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T1 - Biodegradable poly(polyol sebacate) polymers

AU - Bruggeman, Joost P.

AU - de Bruin, Berend-Jan

AU - Bettinger, Christopher J.

AU - Langer, Robert

PY - 2008/12

Y1 - 2008/12

N2 - We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. These thermoset networks exhibited tensile Young's modiali ranging from 0.37 +/- 0.08 to 378 +/- 33 MPa with maximum elongations at break from 10.90 +/- 1.37% to 205.16 +/- 55.76%, and glass transition temperatures ranging from similar to ∼7-46 degrees C. In vitro degradation under physiological conditions was slower than in vivo degradation rates observed for some PPS polymers. PPS polymers demonstrated similar in vitro and in vivo biocompatibility compared to poly(L-lactic-co-glycolic acid) (PLGA).

AB - We have developed a family of synthetic biodegradable polymers that are composed of structural units endogenous to the human metabolism, designated poly(polyol sebacate) (PPS) polymers. Material properties of PPS polymers can be tuned by altering the polyol monomer and reacting stiochiometric ratio of sebacic acid. These thermoset networks exhibited tensile Young's modiali ranging from 0.37 +/- 0.08 to 378 +/- 33 MPa with maximum elongations at break from 10.90 +/- 1.37% to 205.16 +/- 55.76%, and glass transition temperatures ranging from similar to ∼7-46 degrees C. In vitro degradation under physiological conditions was slower than in vivo degradation rates observed for some PPS polymers. PPS polymers demonstrated similar in vitro and in vivo biocompatibility compared to poly(L-lactic-co-glycolic acid) (PLGA).

U2 - 10.1016/j.biomaterials.2008.08.037

DO - 10.1016/j.biomaterials.2008.08.037

M3 - Article

C2 - 18824260

SN - 0142-9612

VL - 29

SP - 4726

EP - 4735

JO - Biomaterials

JF - Biomaterials

IS - 36

ER -

Biodegradable poly(polyol sebacate) polymers

Abstract

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