Biological insights from 108 schizophrenia-associated genetic loci

S Ripke; BM Neale; A Corvin; JTR Walters; KH Farh; PA Holmans; P Lee; B Bulik-Sullivan; DA Collier; HL Huang; TH Pers; I Agartz; E Agerbo; M Albus; M Alexander; F Amin; SA Bacanu; M Begemann; RA Belliveau; J Bene; SE Bergen; E Bevilacqua; TB Bigdeli; DW Black; R Bruggeman; NG Buccola; RL Buckner; W Byerley; W Cahn; GQ Cai; D Campion; RM Cantor; VJ Carr; N Carrera; SV Catts; KD Chambert; RCK Chan; RYL Chen; EYH Chen; W Cheng; EFC Cheung; SA Chong; CR Cloninger; D Cohen; N Cohen; P Cormican; N Craddock; JJ Crowley; D Curtis; M Davidson; KL Davis; F Degenhardt; J Del Favero; D Demontis; D Dikeos; T Dinan; S Djurovic; G Donohoe; E Drapeau; J Duan; F Dudbridge; N Durmishi; P Eichhammer; J Eriksson; V Escott-Price; L Essioux; AH Fanous; MS Farrell; J Frank; L Franke; R Freedman; NB Freimer; M Friedl; JI Friedman; M Fromer; G Genovese; L Georgieva; I Giegling; P Giusti-Rodriguez; S Godard; JI Goldstein; V Golimbet; S Gopal; J Gratten; L (Lieuwe) den Haan; C Hammer; ML Hamshere; M Hansen; T Hansen; V Haroutunian; AM Hartmann; FA Henskens; S Herms; JN Hirschhorn; P Hoffmann; Bert Hofman; MV Hollegaard; DM Hougaard; M Ikeda; I Joa; A Julia; RS Kahn; L Kalaydjieva; S Karachanak-Yankova; J Karjalainen; D Kavanagh; MC Keller; JL Kennedy; A Khrunin; Y. Kim; J Klovins; JA Knowles; B Konte; V Kucinskas; ZA Kucinskiene; H Kuzelova-Ptackova; AK Kahler; C Laurent; JLC Keong; SH Lee; SE Legge; B Lerer; MX Li; T Li; KY Liang; J Lieberman; S Limborska; CM Loughland; J Lubinski; J Lonnqvist; M Macek; PKE Magnusson; BS Maher; W Maier; J Mallet; S Marsal; M Mattheisen; M Mattingsdal; RW McCarley; C McDonald; AM McIntosh; S Meier; Kees Meijer; B Melegh; I Melle; RI Mesholam-Gately; A Metspalu; PT Michie; L Milani; V Milanova; Y Mokrab; DW Morris; O Mors; KC Murphy; RM Murray; I Myin-Germeys; B Muller-Myhsok; M Nelis; I Nenadic; DA Nertney; G Nestadt; KK Nicodemus; L Nikitina-Zake; L Nisenbaum; A Nordin; E O'Callaghan; C O'Dushlaine; FA O'Neill; SY Oh; A Olincy; L Olsen; J van Os; C Pantelis; GN Papadimitriou; S Papiol; E Parkhomenko; MT Pato; T Paunio; M Pejovic-Milovancevic; DO Perkins; O Pietilainen; J Pimm; AJ Pocklington; J Powell; A Price; AE Pulver; SM Purcell; D Quested; HB Rasmussen; A Reichenberg; MA Reimers; AL Richards; JL Roffman; P Roussos; DM Ruderfer; V Salomaa; AR Sanders; U Schall; CR Schubert; TG Schulze; SG Schwab; EM Scolnick; RJ Scott; LJ Seidman; JX Shi; E Sigurdsson; T Silagadze; JM Silverman; K Sim; P Slominsky; JW Smoller; HC So; CCA Spencer; EA Stahl; H Stefansson; S Steinberg; E Stogmann; RE Straub; E Strengman; J Strohmaier; TS Stroup; M Subramaniam; J Suvisaari; DM Svrakic; JP Szatkiewicz; E Soderman; S Thirumalai; D Toncheva; S Tosato; J Veijola; J Waddington; D Walsh; D Wang; Q (Qing) Wang; BT Webb; M Weiser; DB Wildenauer; NM Williams; S Williams; SH Witt; AR Wolen; EHM Wong; BK Wormley; HS Xi; CC Zai; XB Zheng; F Zimprich; NR Wray; K Stefansson; PM Visscher; R Adolfsson; OA Andreassen; DHR Blackwood; E Bramon; JD Buxbaum; AD Borglum; S Cichon; A Darvasi; E Domenici; H Ehrenreich; T Esko; PV Gejman; M Gill; H Gurling; CM Hultman; N Iwata; AV Jablensky; EG Jonsson; KS Kendler; G Kirov; J Knight; T Lencz; DF Levinson; QQS Li; JJ Liu; AK Malhotra; SA McCarroll; A McQuillin; JL Moran; PB Mortensen; BJ Mowry; MM Nothen; RA Ophoff; MJ Owen; A Palotie; CN Pato; TL Petryshen; Daniëlle Posthuma; M Rietschel; BP Riley; D Rujescu; PC Sham; P Sklar; D St Clair; DR Weinberger; JR Wendland; T Werge; MJ Daly; PF Sullivan; MC O'Donovan

doi:10.1038/nature13595

Biological insights from 108 schizophrenia-associated genetic loci

S Ripke, BM Neale, A Corvin, JTR Walters, KH Farh, PA Holmans, P Lee, B Bulik-Sullivan, DA Collier, HL Huang, TH Pers, I Agartz, E Agerbo, M Albus, M Alexander, F Amin, SA Bacanu, M Begemann, RA Belliveau, J BeneSE Bergen, E Bevilacqua, TB Bigdeli, DW Black, R Bruggeman, NG Buccola, RL Buckner, W Byerley, W Cahn, GQ Cai, D Campion, RM Cantor, VJ Carr, N Carrera, SV Catts, KD Chambert, RCK Chan, RYL Chen, EYH Chen, W Cheng, EFC Cheung, SA Chong, CR Cloninger, D Cohen, N Cohen, P Cormican, N Craddock, JJ Crowley, D Curtis, M Davidson, KL Davis, F Degenhardt, J Del Favero, D Demontis, D Dikeos, T Dinan, S Djurovic, G Donohoe, E Drapeau, J Duan, F Dudbridge, N Durmishi, P Eichhammer, J Eriksson, V Escott-Price, L Essioux, AH Fanous, MS Farrell, J Frank, L Franke, R Freedman, NB Freimer, M Friedl, JI Friedman, M Fromer, G Genovese, L Georgieva, I Giegling, P Giusti-Rodriguez, S Godard, JI Goldstein, V Golimbet, S Gopal, J Gratten, L (Lieuwe) den Haan, C Hammer, ML Hamshere, M Hansen, T Hansen, V Haroutunian, AM Hartmann, FA Henskens, S Herms, JN Hirschhorn, P Hoffmann, Bert Hofman, MV Hollegaard, DM Hougaard, M Ikeda, I Joa, A Julia, RS Kahn, L Kalaydjieva, S Karachanak-Yankova, J Karjalainen, D Kavanagh, MC Keller, JL Kennedy, A Khrunin, Y. Kim, J Klovins, JA Knowles, B Konte, V Kucinskas, ZA Kucinskiene, H Kuzelova-Ptackova, AK Kahler, C Laurent, JLC Keong, SH Lee, SE Legge, B Lerer, MX Li, T Li, KY Liang, J Lieberman, S Limborska, CM Loughland, J Lubinski, J Lonnqvist, M Macek, PKE Magnusson, BS Maher, W Maier, J Mallet, S Marsal, M Mattheisen, M Mattingsdal, RW McCarley, C McDonald, AM McIntosh, S Meier, Kees Meijer, B Melegh, I Melle, RI Mesholam-Gately, A Metspalu, PT Michie, L Milani, V Milanova, Y Mokrab, DW Morris, O Mors, KC Murphy, RM Murray, I Myin-Germeys, B Muller-Myhsok, M Nelis, I Nenadic, DA Nertney, G Nestadt, KK Nicodemus, L Nikitina-Zake, L Nisenbaum, A Nordin, E O'Callaghan, C O'Dushlaine, FA O'Neill, SY Oh, A Olincy, L Olsen, J van Os, C Pantelis, GN Papadimitriou, S Papiol, E Parkhomenko, MT Pato, T Paunio, M Pejovic-Milovancevic, DO Perkins, O Pietilainen, J Pimm, AJ Pocklington, J Powell, A Price, AE Pulver, SM Purcell, D Quested, HB Rasmussen, A Reichenberg, MA Reimers, AL Richards, JL Roffman, P Roussos, DM Ruderfer, V Salomaa, AR Sanders, U Schall, CR Schubert, TG Schulze, SG Schwab, EM Scolnick, RJ Scott, LJ Seidman, JX Shi, E Sigurdsson, T Silagadze, JM Silverman, K Sim, P Slominsky, JW Smoller, HC So, CCA Spencer, EA Stahl, H Stefansson, S Steinberg, E Stogmann, RE Straub, E Strengman, J Strohmaier, TS Stroup, M Subramaniam, J Suvisaari, DM Svrakic, JP Szatkiewicz, E Soderman, S Thirumalai, D Toncheva, S Tosato, J Veijola, J Waddington, D Walsh, D Wang, Q (Qing) Wang, BT Webb, M Weiser, DB Wildenauer, NM Williams, S Williams, SH Witt, AR Wolen, EHM Wong, BK Wormley, HS Xi, CC Zai, XB Zheng, F Zimprich, NR Wray, K Stefansson, PM Visscher, R Adolfsson, OA Andreassen, DHR Blackwood, E Bramon, JD Buxbaum, AD Borglum, S Cichon, A Darvasi, E Domenici, H Ehrenreich, T Esko, PV Gejman, M Gill, H Gurling, CM Hultman, N Iwata, AV Jablensky, EG Jonsson, KS Kendler, G Kirov, J Knight, T Lencz, DF Levinson, QQS Li, JJ Liu, AK Malhotra, SA McCarroll, A McQuillin, JL Moran, PB Mortensen, BJ Mowry, MM Nothen, RA Ophoff, MJ Owen, A Palotie, CN Pato, TL Petryshen, Daniëlle Posthuma, M Rietschel, BP Riley, D Rujescu, PC Sham, P Sklar, D St Clair, DR Weinberger, JR Wendland, T Werge, MJ Daly, PF Sullivan, MC O'Donovan

Research output: Contribution to journal › Article › Academic › peer-review

5954 Citations (Scopus)

Abstract

Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.

Original language	Undefined/Unknown
Pages (from-to)	421-+
Journal	Nature
Volume	511
Issue number	7510
DOIs	https://doi.org/10.1038/nature13595
Publication status	Published - 2014

Research programs

EMC NIHES-01-64-01

Access to Document

10.1038/nature13595

http://hdl.handle.net/1765/59882

Cite this

Ripke, S., Neale, BM., Corvin, A., Walters, JTR., Farh, KH., Holmans, PA., Lee, P., Bulik-Sullivan, B., Collier, DA., Huang, HL., Pers, TH., Agartz, I., Agerbo, E., Albus, M., Alexander, M., Amin, F., Bacanu, SA., Begemann, M., Belliveau, RA., ... O'Donovan, MC. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511(7510), 421-+. https://doi.org/10.1038/nature13595

@article{c7ac1a72cc1e4631a6e93d2aca8f5023,

title = "Biological insights from 108 schizophrenia-associated genetic loci",

abstract = "Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.",

author = "S Ripke and BM Neale and A Corvin and JTR Walters and KH Farh and PA Holmans and P Lee and B Bulik-Sullivan and DA Collier and HL Huang and TH Pers and I Agartz and E Agerbo and M Albus and M Alexander and F Amin and SA Bacanu and M Begemann and RA Belliveau and J Bene and SE Bergen and E Bevilacqua and TB Bigdeli and DW Black and R Bruggeman and NG Buccola and RL Buckner and W Byerley and W Cahn and GQ Cai and D Campion and RM Cantor and VJ Carr and N Carrera and SV Catts and KD Chambert and RCK Chan and RYL Chen and EYH Chen and W Cheng and EFC Cheung and SA Chong and CR Cloninger and D Cohen and N Cohen and P Cormican and N Craddock and JJ Crowley and D Curtis and M Davidson and KL Davis and F Degenhardt and {Del Favero}, J and D Demontis and D Dikeos and T Dinan and S Djurovic and G Donohoe and E Drapeau and J Duan and F Dudbridge and N Durmishi and P Eichhammer and J Eriksson and V Escott-Price and L Essioux and AH Fanous and MS Farrell and J Frank and L Franke and R Freedman and NB Freimer and M Friedl and JI Friedman and M Fromer and G Genovese and L Georgieva and I Giegling and P Giusti-Rodriguez and S Godard and JI Goldstein and V Golimbet and S Gopal and J Gratten and {den Haan}, {L (Lieuwe)} and C Hammer and ML Hamshere and M Hansen and T Hansen and V Haroutunian and AM Hartmann and FA Henskens and S Herms and JN Hirschhorn and P Hoffmann and Bert Hofman and MV Hollegaard and DM Hougaard and M Ikeda and I Joa and A Julia and RS Kahn and L Kalaydjieva and S Karachanak-Yankova and J Karjalainen and D Kavanagh and MC Keller and JL Kennedy and A Khrunin and Y. Kim and J Klovins and JA Knowles and B Konte and V Kucinskas and ZA Kucinskiene and H Kuzelova-Ptackova and AK Kahler and C Laurent and JLC Keong and SH Lee and SE Legge and B Lerer and MX Li and T Li and KY Liang and J Lieberman and S Limborska and CM Loughland and J Lubinski and J Lonnqvist and M Macek and PKE Magnusson and BS Maher and W Maier and J Mallet and S Marsal and M Mattheisen and M Mattingsdal and RW McCarley and C McDonald and AM McIntosh and S Meier and Kees Meijer and B Melegh and I Melle and RI Mesholam-Gately and A Metspalu and PT Michie and L Milani and V Milanova and Y Mokrab and DW Morris and O Mors and KC Murphy and RM Murray and I Myin-Germeys and B Muller-Myhsok and M Nelis and I Nenadic and DA Nertney and G Nestadt and KK Nicodemus and L Nikitina-Zake and L Nisenbaum and A Nordin and E O'Callaghan and C O'Dushlaine and FA O'Neill and SY Oh and A Olincy and L Olsen and {van Os}, J and C Pantelis and GN Papadimitriou and S Papiol and E Parkhomenko and MT Pato and T Paunio and M Pejovic-Milovancevic and DO Perkins and O Pietilainen and J Pimm and AJ Pocklington and J Powell and A Price and AE Pulver and SM Purcell and D Quested and HB Rasmussen and A Reichenberg and MA Reimers and AL Richards and JL Roffman and P Roussos and DM Ruderfer and V Salomaa and AR Sanders and U Schall and CR Schubert and TG Schulze and SG Schwab and EM Scolnick and RJ Scott and LJ Seidman and JX Shi and E Sigurdsson and T Silagadze and JM Silverman and K Sim and P Slominsky and JW Smoller and HC So and CCA Spencer and EA Stahl and H Stefansson and S Steinberg and E Stogmann and RE Straub and E Strengman and J Strohmaier and TS Stroup and M Subramaniam and J Suvisaari and DM Svrakic and JP Szatkiewicz and E Soderman and S Thirumalai and D Toncheva and S Tosato and J Veijola and J Waddington and D Walsh and D Wang and Wang, {Q (Qing)} and BT Webb and M Weiser and DB Wildenauer and NM Williams and S Williams and SH Witt and AR Wolen and EHM Wong and BK Wormley and HS Xi and CC Zai and XB Zheng and F Zimprich and NR Wray and K Stefansson and PM Visscher and R Adolfsson and OA Andreassen and DHR Blackwood and E Bramon and JD Buxbaum and AD Borglum and S Cichon and A Darvasi and E Domenici and H Ehrenreich and T Esko and PV Gejman and M Gill and H Gurling and CM Hultman and N Iwata and AV Jablensky and EG Jonsson and KS Kendler and G Kirov and J Knight and T Lencz and DF Levinson and QQS Li and JJ Liu and AK Malhotra and SA McCarroll and A McQuillin and JL Moran and PB Mortensen and BJ Mowry and MM Nothen and RA Ophoff and MJ Owen and A Palotie and CN Pato and TL Petryshen and Dani{\"e}lle Posthuma and M Rietschel and BP Riley and D Rujescu and PC Sham and P Sklar and {St Clair}, D and DR Weinberger and JR Wendland and T Werge and MJ Daly and PF Sullivan and MC O'Donovan",

year = "2014",

doi = "10.1038/nature13595",

language = "Undefined/Unknown",

volume = "511",

pages = "421--+",

journal = "Nature",

issn = "0028-0836",

publisher = "Nature Research",

number = "7510",

}

Ripke, S, Neale, BM, Corvin, A, Walters, JTR, Farh, KH, Holmans, PA, Lee, P, Bulik-Sullivan, B, Collier, DA, Huang, HL, Pers, TH, Agartz, I, Agerbo, E, Albus, M, Alexander, M, Amin, F, Bacanu, SA, Begemann, M, Belliveau, RA, Bene, J, Bergen, SE, Bevilacqua, E, Bigdeli, TB, Black, DW, Bruggeman, R, Buccola, NG, Buckner, RL, Byerley, W, Cahn, W, Cai, GQ, Campion, D, Cantor, RM, Carr, VJ, Carrera, N, Catts, SV, Chambert, KD, Chan, RCK, Chen, RYL, Chen, EYH, Cheng, W, Cheung, EFC, Chong, SA, Cloninger, CR, Cohen, D, Cohen, N, Cormican, P, Craddock, N, Crowley, JJ, Curtis, D, Davidson, M, Davis, KL, Degenhardt, F, Del Favero, J, Demontis, D, Dikeos, D, Dinan, T, Djurovic, S, Donohoe, G, Drapeau, E, Duan, J, Dudbridge, F, Durmishi, N, Eichhammer, P, Eriksson, J, Escott-Price, V, Essioux, L, Fanous, AH, Farrell, MS, Frank, J, Franke, L, Freedman, R, Freimer, NB, Friedl, M, Friedman, JI, Fromer, M, Genovese, G, Georgieva, L, Giegling, I, Giusti-Rodriguez, P, Godard, S, Goldstein, JI, Golimbet, V, Gopal, S, Gratten, J, den Haan, L, Hammer, C, Hamshere, ML, Hansen, M, Hansen, T, Haroutunian, V, Hartmann, AM, Henskens, FA, Herms, S, Hirschhorn, JN, Hoffmann, P, Hofman, B, Hollegaard, MV, Hougaard, DM, Ikeda, M, Joa, I, Julia, A, Kahn, RS, Kalaydjieva, L, Karachanak-Yankova, S, Karjalainen, J, Kavanagh, D, Keller, MC, Kennedy, JL, Khrunin, A, Kim, Y, Klovins, J, Knowles, JA, Konte, B, Kucinskas, V, Kucinskiene, ZA, Kuzelova-Ptackova, H, Kahler, AK, Laurent, C, Keong, JLC, Lee, SH, Legge, SE, Lerer, B, Li, MX, Li, T, Liang, KY, Lieberman, J, Limborska, S, Loughland, CM, Lubinski, J, Lonnqvist, J, Macek, M, Magnusson, PKE, Maher, BS, Maier, W, Mallet, J, Marsal, S, Mattheisen, M, Mattingsdal, M, McCarley, RW, McDonald, C, McIntosh, AM, Meier, S, Meijer, K, Melegh, B, Melle, I, Mesholam-Gately, RI, Metspalu, A, Michie, PT, Milani, L, Milanova, V, Mokrab, Y, Morris, DW, Mors, O, Murphy, KC, Murray, RM, Myin-Germeys, I, Muller-Myhsok, B, Nelis, M, Nenadic, I, Nertney, DA, Nestadt, G, Nicodemus, KK, Nikitina-Zake, L, Nisenbaum, L, Nordin, A, O'Callaghan, E, O'Dushlaine, C, O'Neill, FA, Oh, SY, Olincy, A, Olsen, L, van Os, J, Pantelis, C, Papadimitriou, GN, Papiol, S, Parkhomenko, E, Pato, MT, Paunio, T, Pejovic-Milovancevic, M, Perkins, DO, Pietilainen, O, Pimm, J, Pocklington, AJ, Powell, J, Price, A, Pulver, AE, Purcell, SM, Quested, D, Rasmussen, HB, Reichenberg, A, Reimers, MA, Richards, AL, Roffman, JL, Roussos, P, Ruderfer, DM, Salomaa, V, Sanders, AR, Schall, U, Schubert, CR, Schulze, TG, Schwab, SG, Scolnick, EM, Scott, RJ, Seidman, LJ, Shi, JX, Sigurdsson, E, Silagadze, T, Silverman, JM, Sim, K, Slominsky, P, Smoller, JW, So, HC, Spencer, CCA, Stahl, EA, Stefansson, H, Steinberg, S, Stogmann, E, Straub, RE, Strengman, E, Strohmaier, J, Stroup, TS, Subramaniam, M, Suvisaari, J, Svrakic, DM, Szatkiewicz, JP, Soderman, E, Thirumalai, S, Toncheva, D, Tosato, S, Veijola, J, Waddington, J, Walsh, D, Wang, D, Wang, Q, Webb, BT, Weiser, M, Wildenauer, DB, Williams, NM, Williams, S, Witt, SH, Wolen, AR, Wong, EHM, Wormley, BK, Xi, HS, Zai, CC, Zheng, XB, Zimprich, F, Wray, NR, Stefansson, K, Visscher, PM, Adolfsson, R, Andreassen, OA, Blackwood, DHR, Bramon, E, Buxbaum, JD, Borglum, AD, Cichon, S, Darvasi, A, Domenici, E, Ehrenreich, H, Esko, T, Gejman, PV, Gill, M, Gurling, H, Hultman, CM, Iwata, N, Jablensky, AV, Jonsson, EG, Kendler, KS, Kirov, G, Knight, J, Lencz, T, Levinson, DF, Li, QQS, Liu, JJ, Malhotra, AK, McCarroll, SA, McQuillin, A, Moran, JL, Mortensen, PB, Mowry, BJ, Nothen, MM, Ophoff, RA, Owen, MJ, Palotie, A, Pato, CN, Petryshen, TL, Posthuma, D, Rietschel, M, Riley, BP, Rujescu, D, Sham, PC, Sklar, P, St Clair, D, Weinberger, DR, Wendland, JR, Werge, T, Daly, MJ, Sullivan, PF & O'Donovan, MC 2014, 'Biological insights from 108 schizophrenia-associated genetic loci', Nature, vol. 511, no. 7510, pp. 421-+. https://doi.org/10.1038/nature13595

TY - JOUR

T1 - Biological insights from 108 schizophrenia-associated genetic loci

AU - Ripke, S

AU - Neale, BM

AU - Corvin, A

AU - Walters, JTR

AU - Farh, KH

AU - Holmans, PA

AU - Lee, P

AU - Bulik-Sullivan, B

AU - Collier, DA

AU - Huang, HL

AU - Pers, TH

AU - Agartz, I

AU - Agerbo, E

AU - Albus, M

AU - Alexander, M

AU - Amin, F

AU - Bacanu, SA

AU - Begemann, M

AU - Belliveau, RA

AU - Bene, J

AU - Bergen, SE

AU - Bevilacqua, E

AU - Bigdeli, TB

AU - Black, DW

AU - Bruggeman, R

AU - Buccola, NG

AU - Buckner, RL

AU - Byerley, W

AU - Cahn, W

AU - Cai, GQ

AU - Campion, D

AU - Cantor, RM

AU - Carr, VJ

AU - Carrera, N

AU - Catts, SV

AU - Chambert, KD

AU - Chan, RCK

AU - Chen, RYL

AU - Chen, EYH

AU - Cheng, W

AU - Cheung, EFC

AU - Chong, SA

AU - Cloninger, CR

AU - Cohen, D

AU - Cohen, N

AU - Cormican, P

AU - Craddock, N

AU - Crowley, JJ

AU - Curtis, D

AU - Davidson, M

AU - Davis, KL

AU - Degenhardt, F

AU - Del Favero, J

AU - Demontis, D

AU - Dikeos, D

AU - Dinan, T

AU - Djurovic, S

AU - Donohoe, G

AU - Drapeau, E

AU - Duan, J

AU - Dudbridge, F

AU - Durmishi, N

AU - Eichhammer, P

AU - Eriksson, J

AU - Escott-Price, V

AU - Essioux, L

AU - Fanous, AH

AU - Farrell, MS

AU - Frank, J

AU - Franke, L

AU - Freedman, R

AU - Freimer, NB

AU - Friedl, M

AU - Friedman, JI

AU - Fromer, M

AU - Genovese, G

AU - Georgieva, L

AU - Giegling, I

AU - Giusti-Rodriguez, P

AU - Godard, S

AU - Goldstein, JI

AU - Golimbet, V

AU - Gopal, S

AU - Gratten, J

AU - den Haan, L (Lieuwe)

AU - Hammer, C

AU - Hamshere, ML

AU - Hansen, M

AU - Hansen, T

AU - Haroutunian, V

AU - Hartmann, AM

AU - Henskens, FA

AU - Herms, S

AU - Hirschhorn, JN

AU - Hoffmann, P

AU - Hofman, Bert

AU - Hollegaard, MV

AU - Hougaard, DM

AU - Ikeda, M

AU - Joa, I

AU - Julia, A

AU - Kahn, RS

AU - Kalaydjieva, L

AU - Karachanak-Yankova, S

AU - Karjalainen, J

AU - Kavanagh, D

AU - Keller, MC

AU - Kennedy, JL

AU - Khrunin, A

AU - Kim, Y.

AU - Klovins, J

AU - Knowles, JA

AU - Konte, B

AU - Kucinskas, V

AU - Kucinskiene, ZA

AU - Kuzelova-Ptackova, H

AU - Kahler, AK

AU - Laurent, C

AU - Keong, JLC

AU - Lee, SH

AU - Legge, SE

AU - Lerer, B

AU - Li, MX

AU - Li, T

AU - Liang, KY

AU - Lieberman, J

AU - Limborska, S

AU - Loughland, CM

AU - Lubinski, J

AU - Lonnqvist, J

AU - Macek, M

AU - Magnusson, PKE

AU - Maher, BS

AU - Maier, W

AU - Mallet, J

AU - Marsal, S

AU - Mattheisen, M

AU - Mattingsdal, M

AU - McCarley, RW

AU - McDonald, C

AU - McIntosh, AM

AU - Meier, S

AU - Meijer, Kees

AU - Melegh, B

AU - Melle, I

AU - Mesholam-Gately, RI

AU - Metspalu, A

AU - Michie, PT

AU - Milani, L

AU - Milanova, V

AU - Mokrab, Y

AU - Morris, DW

AU - Mors, O

AU - Murphy, KC

AU - Murray, RM

AU - Myin-Germeys, I

AU - Muller-Myhsok, B

AU - Nelis, M

AU - Nenadic, I

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AU - Sullivan, PF

AU - O'Donovan, MC

PY - 2014

Y1 - 2014

N2 - Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.

AB - Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of alleles, including common alleles of small effect that might be detected by genome-wide association studies. Here we report a multi-stage schizophrenia genome-wide association study of up to 36,989 cases and 113,075 controls. We identify 128 independent associations spanning 108 conservatively defined loci that meet genome-wide significance, 83 of which have not been previously reported. Associations were enriched among genes expressed in brain, providing biological plausibility for the findings. Many findings have the potential to provide entirely new insights into aetiology, but associations at DRD2 and several genes involved in glutamatergic neurotransmission highlight molecules of known and potential therapeutic relevance to schizophrenia, and are consistent with leading pathophysiological hypotheses. Independent of genes expressed in brain, associations were enriched among genes expressed in tissues that have important roles in immunity, providing support for the speculated link between the immune system and schizophrenia.

U2 - 10.1038/nature13595

DO - 10.1038/nature13595

M3 - Article

C2 - 25056061

SN - 0028-0836

VL - 511

SP - 421-+

JO - Nature

JF - Nature

IS - 7510

ER -