Biological interpretation of genome-wide association studies using predicted gene functions

TH Pers; JM Karjalainen; Y Chan; HJ Westra; AR Wood; Jiaqi Yang; JC Lui; S Vedantam; S Gustafsson; T Esko; T Frayling; EK Speliotes; M Boehnke; S Raychaudhuri; RSN Fehrmann; JN Hirschhorn; L Franke

doi:10.1038/ncomms6890

Biological interpretation of genome-wide association studies using predicted gene functions

TH Pers, JM Karjalainen, Y Chan, HJ Westra, AR Wood, Jiaqi Yang, JC Lui, S Vedantam, S Gustafsson, T Esko, T Frayling, EK Speliotes, M Boehnke, S Raychaudhuri, RSN Fehrmann, JN Hirschhorn, L Franke

Research output: Contribution to journal › Article › Academic › peer-review

526 Citations (Scopus)

Abstract

The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.

Original language	Undefined/Unknown
Journal	Nature Communications
Volume	6
DOIs	https://doi.org/10.1038/ncomms6890
Publication status	Published - 2015
Externally published	Yes

Bibliographical note

Geen EMC auteur, alleen in Group Authors

Research programs

EMC MGC-02-26-01
EMC NIHES-01-64-02
EMC OR-01-39-08

Access to Document

10.1038/ncomms6890

Cite this

Pers, TH., Karjalainen, JM., Chan, Y., Westra, HJ., Wood, AR., Yang, J., Lui, JC., Vedantam, S., Gustafsson, S., Esko, T., Frayling, T., Speliotes, EK., Boehnke, M., Raychaudhuri, S., Fehrmann, RSN., Hirschhorn, JN., & Franke, L. (2015). Biological interpretation of genome-wide association studies using predicted gene functions. Nature Communications, 6. https://doi.org/10.1038/ncomms6890

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Pers, TH, Karjalainen, JM, Chan, Y, Westra, HJ, Wood, AR, Yang, J, Lui, JC, Vedantam, S, Gustafsson, S, Esko, T, Frayling, T, Speliotes, EK, Boehnke, M, Raychaudhuri, S, Fehrmann, RSN, Hirschhorn, JN & Franke, L 2015, 'Biological interpretation of genome-wide association studies using predicted gene functions', Nature Communications, vol. 6. https://doi.org/10.1038/ncomms6890

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AU - Pers, TH

AU - Karjalainen, JM

AU - Chan, Y

AU - Westra, HJ

AU - Wood, AR

AU - Yang, Jiaqi

AU - Lui, JC

AU - Vedantam, S

AU - Gustafsson, S

AU - Esko, T

AU - Frayling, T

AU - Speliotes, EK

AU - Boehnke, M

AU - Raychaudhuri, S

AU - Fehrmann, RSN

AU - Hirschhorn, JN

AU - Franke, L

N1 - Geen EMC auteur, alleen in Group Authors

PY - 2015

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AB - The main challenge for gaining biological insights from genetic associations is identifying which genes and pathways explain the associations. Here we present DEPICT, an integrative tool that employs predicted gene functions to systematically prioritize the most likely causal genes at associated loci, highlight enriched pathways and identify tissues/cell types where genes from associated loci are highly expressed. DEPICT is not limited to genes with established functions and prioritizes relevant gene sets for many phenotypes.

U2 - 10.1038/ncomms6890

DO - 10.1038/ncomms6890

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