Biological pathways and genetic mechanisms involved in social functioning

JR Ordonana, M Bartels, DI Boomsma, D Cella, M Mosing, JR Oliviera, DL Patrick, MAG Sprangers, R Veenhoven

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: To describe the major findings in the literature regarding associations between biologicaland genetic factors and social functioning, paying special attention to: (1) heritability studieson social functioning and related concepts; (2) hypothesized biological pathways and geneticvariants that could be involved in social functioning, and (3) the implications of these results for quality-of-life research. Methods: A search of Web of Science and PubMed databases was conducted using combinations ofthe following keywords: genetics, twins, heritability, social functioning, social adjustment, social interaction, and social dysfunction. Results:Variability in the definitions and measures of social functioning was extensive. Moderate to high heritability was reported for social functioning and related concepts, including prosocial behavior, loneliness, and extraversion. Disorders characterized by impairments in social functioning also show substantial heritability. Genetic variants hypothesized to be involved in social functioning are related to the network of brain structures and processes that are known to affect social cognition and behavior. Conclusions: Better knowledge and understanding about the impact of genetic factors on social functioning is needed to help us attain a more comprehensover view of health related qual;ity-of-life (HQOL), and will ultimately enhance our ability to identify those patients who are vulnerable to poor social functioning. Keywords: Quality of life, Social functioning, Patient-reported outcomes, Genetic variants, Genetic underpinning
Original languageFrench
JournalQuality of Life Research
Publication statusPublished - 1 Oct 2012

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