Biologicals for pediatric patients with atopic dermatitis: practical challenges and knowledge gaps

Lisa P. van der Rijst, Annet van Royen-Kerkhof, Suzanne G.M.A. Pasmans, Renske Schappin, Marjolein S. de Bruin-Weller, Marlies de Graaf*

*Corresponding author for this work

Research output: Contribution to journalComment/Letter to the editorAcademicpeer-review

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Biologicals are becoming increasingly important in the therapeutic landscape of pediatric patients with moderate-to-severe atopic dermatitis (AD). Currently, dupilumab and tralokinumab are registered for the treatment of moderate-to-severe AD, and novel biologicals are expected to follow. Dupilumab was the first biological registered for AD in pediatric patients and was recently approved for patients aged six months to five years. Current and emerging biologicals may address the unmet need for effective and safe treatment options for pediatric AD patients, however, little is known about the practical implementation of biologicals in infants and preschoolers (aged <6 years), including the timing of treatment initiation, discontinuation, and long-term administration of the subcutaneous injections. Currently, only a small number of biologicals are approved for the treatment of infants and preschoolers for other inflammatory diseases. Consequently, data on the practical implementation of biological treatment remain scarce. In addition, long-term effects, impact on co-morbidities, and impact on live-accentuated vaccination are still unknown. With the introduction of biologicals for AD from the age of six months, potential challenges within the implementation of biologicals may arise. Therefore, we aim to discuss current practical challenges and knowledge gaps of the treatment with biologicals in infants and preschoolers with AD.

Original languageEnglish
Article number2254567
JournalJournal of Dermatological Treatment
Issue number1
Publication statusPublished - 4 Sept 2023

Bibliographical note

Funding Information:
This work was not supported by funding.

Publisher Copyright:
© 2023 The Author(s). Published with license by Taylor & Francis Group, LLC.


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