Biology of lung macrophages in health and disease

Helena Aegerter, Bart N. Lambrecht, Claudia V. Jakubzick*

*Corresponding author for this work

Research output: Contribution to journalReview articleAcademicpeer-review

7 Citations (Scopus)

Abstract

Tissue-resident alveolar and interstitial macrophages and recruited macrophages are critical players in innate immunity and maintenance of lung homeostasis. Until recently, assessing the differential functional contributions of tissue-resident versus recruited macrophages has been challenging because they share overlapping cell surface markers, making it difficult to separate them using conventional methods. This review describes how scRNA-seq and spatial transcriptomics can separate these subpopulations and help unravel the complexity of macrophage biology in homeostasis and disease. First, we provide a guide to identifying and distinguishing lung macrophages from other mononuclear phagocytes in humans and mice. Second, we outline emerging concepts related to the development and function of the various lung macrophages in the alveolar, perivascular, and interstitial niches. Finally, we describe how different tissue states profoundly alter their functions, including acute and chronic lung disease, cancer, and aging.

Original languageEnglish
Pages (from-to)1564-1580
Number of pages17
JournalImmunity
Volume55
Issue number9
DOIs
Publication statusPublished - 13 Sep 2022

Bibliographical note

ACKNOWLEDGMENTS
B.N.L. is supported by a FWO Methusalem grant, and by an FWO Excellence of Science grant. He has received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation programme (grant agreement No 789384). H.A. is supported by an FWOVLAIO Fellowship. C.V.J. is supported by National Institutes of Health grant
R35 HL155458.

Publisher Copyright: Copyright © 2022 Elsevier Inc. All rights reserved.

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