TY - JOUR
T1 - Biomarker S100B in plasma a screening tool for mild traumatic brain injury in an emergency department
AU - H. Hopman, Joëlla
AU - A. L. Santing, Juliette
AU - A. Foks, Kelly
AU - J. Verheul, Rolf
AU - M. van der Linden, Christien
AU - L. van den Brand, Crispijn
AU - Jellema, Korné
N1 - Funding Information:
This study was supported by Roche Diagnostics. They had no role in the design, conduct, analysis, or content of this research or article.
Publisher Copyright:
© 2022 Taylor & Francis Group, LLC.
PY - 2023
Y1 - 2023
N2 - Introduction: A computerized tomography (CT) scan is an effective test for detecting traumatic intracranial findings after mild traumatic brain injury (mTBI). However, a head CT is costly, and can only be performed in a hospital. Objective: To determine if the addition of plasma S100B to clinical guidelines could lead to a more selective scanning strategy without compromising safety. Methods: We conducted a single center prospective cohort study at the emergency department. Patients (≥16 years) who received head CT and had a blood draw were included. The primary outcome was the accuracy of plasma S100B to predict the presence of any traumatic intracranial lesion on head CT. Results: We included 495 patients, out of the 74 patients who had traumatic intracranial lesions, 5 patients had a plasma S100B level below the cutoff value of 0.105 ug/L. For the detection of traumatic intracranial injury, S100B had a sensitivity of 0.932, a specificity of 0.157, a negative predictive value of 0.930, and a positive predictive value of 0.163. Conclusions: Among patients undergoing guideline-based CT scan for mTBI, the use of S100B, would results in a further decrease (14.8%) of CT scans but at a cost of missed injury, without clinical consequence, on CT.
AB - Introduction: A computerized tomography (CT) scan is an effective test for detecting traumatic intracranial findings after mild traumatic brain injury (mTBI). However, a head CT is costly, and can only be performed in a hospital. Objective: To determine if the addition of plasma S100B to clinical guidelines could lead to a more selective scanning strategy without compromising safety. Methods: We conducted a single center prospective cohort study at the emergency department. Patients (≥16 years) who received head CT and had a blood draw were included. The primary outcome was the accuracy of plasma S100B to predict the presence of any traumatic intracranial lesion on head CT. Results: We included 495 patients, out of the 74 patients who had traumatic intracranial lesions, 5 patients had a plasma S100B level below the cutoff value of 0.105 ug/L. For the detection of traumatic intracranial injury, S100B had a sensitivity of 0.932, a specificity of 0.157, a negative predictive value of 0.930, and a positive predictive value of 0.163. Conclusions: Among patients undergoing guideline-based CT scan for mTBI, the use of S100B, would results in a further decrease (14.8%) of CT scans but at a cost of missed injury, without clinical consequence, on CT.
UR - http://www.scopus.com/inward/record.url?scp=85142245054&partnerID=8YFLogxK
U2 - 10.1080/02699052.2022.2145360
DO - 10.1080/02699052.2022.2145360
M3 - Article
C2 - 36397287
AN - SCOPUS:85142245054
SN - 0269-9052
VL - 37
SP - 47
EP - 53
JO - Brain Injury
JF - Brain Injury
IS - 1
ER -