Biomarkers: Cardiovascular Biomarkers: Translational Aspects of Hypertension, Atherosclerosis, and Heart Failure in Drug Development

A. Rogier van der Velde; Wouter C. Meijers; Rudolf A. de Boer

doi:10.1016/B978-0-12-800687-0.00018-9

Biomarkers: Cardiovascular Biomarkers: Translational Aspects of Hypertension, Atherosclerosis, and Heart Failure in Drug Development

A. Rogier van der Velde^*, Wouter C. Meijers, Rudolf A. de Boer

^*Corresponding author for this work

Research output: Chapter/Conference proceeding › Chapter › Academic

7 Citations (Scopus)

Abstract

Biomarkers are the base of any description of physiology, disease and interventional effects including those by drugs. Their value in aiding translational processes may range from nonspecific, unreliable or inaccessible to highly predictive or even surrogate quality precisely predicting clinical endpoints. Thus, identification, development and validation of biomarkers are pivotal for translational processes, and related predictivity scoring represent important sources supporting prioritization and improvement plans. They could be single or multiple readouts with challenges regarding statistical multiplicity issues, and are specifically chosen to support a given project. Most biomarkers are derived from biological fluids, or imaging procedures. Examples are given for cardiovascular, oncological and CNS biomarkers.

Original language	English
Title of host publication	Principles of Translational Science in Medicine
Subtitle of host publication	From Bench to Bedside: Second Edition
Publisher	Elsevier Inc.
Pages	167-183
Number of pages	17
ISBN (Electronic)	9780128007211
ISBN (Print)	9780128006870
DOIs	https://doi.org/10.1016/B978-0-12-800687-0.00018-9
Publication status	Published - 7 Apr 2015
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2015 Elsevier Inc. All rights reserved.

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Rogier van der Velde, A., Meijers, W. C., & de Boer, R. A. (2015). Biomarkers: Cardiovascular Biomarkers: Translational Aspects of Hypertension, Atherosclerosis, and Heart Failure in Drug Development. In Principles of Translational Science in Medicine: From Bench to Bedside: Second Edition (pp. 167-183). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-800687-0.00018-9

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Biomarkers: Cardiovascular Biomarkers: Translational Aspects of Hypertension, Atherosclerosis, and Heart Failure in Drug Development. / Rogier van der Velde, A.; Meijers, Wouter C.; de Boer, Rudolf A.
Principles of Translational Science in Medicine: From Bench to Bedside: Second Edition. Elsevier Inc., 2015. p. 167-183.

Research output: Chapter/Conference proceeding › Chapter › Academic

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Biomarkers: Cardiovascular Biomarkers: Translational Aspects of Hypertension, Atherosclerosis, and Heart Failure in Drug Development

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