TY - JOUR
T1 - Biopsy prostate cancer perineural invasion and tumour load are associated with positive posterolateral margins at radical prostatectomy
T2 - implications for planning of nerve-sparing surgery
AU - van der Slot, Margaretha A.
AU - Remmers, Sebastiaan
AU - the Anser Prostate Cancer Network
AU - Kweldam, Charlotte F.
AU - den Bakker, Michael A.
AU - Nieboer, Daan
AU - Busstra, Martijn B.
AU - Gan, Melanie
AU - Klaver, Sjoerd
AU - Rietbergen, John B.W.
AU - van Leenders, Geert J.L.H.
N1 - Funding Information:
The study was sponsored by a generous grant from the BeterKeten Foundation.
Publisher Copyright:
© 2023 The Authors. Histopathology published by John Wiley & Sons Ltd.
PY - 2023/9
Y1 - 2023/9
N2 - Aims: Radical prostatectomy (RP) for prostate cancer is frequently complicated by erectile dysfunction and urinary incontinence. However, sparing of the nerve bundles adjacent to the posterolateral sides of the prostate reduces the number of complications at the risk of positive surgical margins. Preoperative selection of men eligible for safe, nerve-sparing surgery is therefore needed. Our aim was to identify pathological factors associated with positive posterolateral surgical margins in men undergoing bilateral nerve-sparing RP. Methods and results: Prostate cancer patients undergoing RP with standardised intra-operative surgical margin assessment according to the NeuroSAFE technique were included. Preoperative biopsies were reviewed for grade group (GG), cribriform and/or intraductal carcinoma (CR/IDC), perineural invasion (PNI), cumulative tumour length and extraprostatic extension (EPE). Of 624 included patients, 573 (91.8%) received NeuroSAFE bilaterally and 51 (8.2%) unilaterally, resulting in a total of 1197 intraoperative posterolateral surgical margin assessments. Side-specific biopsy findings were correlated to ipsilateral NeuroSAFE outcome. Higher biopsy GG, CR/IDC, PNI, EPE, number of positive biopsies and cumulative tumour length were all associated with positive posterolateral margins. In multivariable bivariate logistic regression, ipsilateral PNI [odds ratio (OR) = 2.98, 95% confidence interval (CI) = 1.62–5.48; P < 0.001] and percentage of positive cores (OR = 1.18, 95% CI = 1.08–1.29; P < 0.001) were significant predictors for a positive posterolateral margin, while GG and CR/IDC were not. Conclusions: Ipsilateral PNI and percentage of positive cores were significant predictors for a positive posterolateral surgical margin at RP. Biopsy PNI and tumour volume can therefore support clinical decision-making on the level of nerve-sparing surgery in prostate cancer patients.
AB - Aims: Radical prostatectomy (RP) for prostate cancer is frequently complicated by erectile dysfunction and urinary incontinence. However, sparing of the nerve bundles adjacent to the posterolateral sides of the prostate reduces the number of complications at the risk of positive surgical margins. Preoperative selection of men eligible for safe, nerve-sparing surgery is therefore needed. Our aim was to identify pathological factors associated with positive posterolateral surgical margins in men undergoing bilateral nerve-sparing RP. Methods and results: Prostate cancer patients undergoing RP with standardised intra-operative surgical margin assessment according to the NeuroSAFE technique were included. Preoperative biopsies were reviewed for grade group (GG), cribriform and/or intraductal carcinoma (CR/IDC), perineural invasion (PNI), cumulative tumour length and extraprostatic extension (EPE). Of 624 included patients, 573 (91.8%) received NeuroSAFE bilaterally and 51 (8.2%) unilaterally, resulting in a total of 1197 intraoperative posterolateral surgical margin assessments. Side-specific biopsy findings were correlated to ipsilateral NeuroSAFE outcome. Higher biopsy GG, CR/IDC, PNI, EPE, number of positive biopsies and cumulative tumour length were all associated with positive posterolateral margins. In multivariable bivariate logistic regression, ipsilateral PNI [odds ratio (OR) = 2.98, 95% confidence interval (CI) = 1.62–5.48; P < 0.001] and percentage of positive cores (OR = 1.18, 95% CI = 1.08–1.29; P < 0.001) were significant predictors for a positive posterolateral margin, while GG and CR/IDC were not. Conclusions: Ipsilateral PNI and percentage of positive cores were significant predictors for a positive posterolateral surgical margin at RP. Biopsy PNI and tumour volume can therefore support clinical decision-making on the level of nerve-sparing surgery in prostate cancer patients.
UR - http://www.scopus.com/inward/record.url?scp=85156217198&partnerID=8YFLogxK
U2 - 10.1111/his.14934
DO - 10.1111/his.14934
M3 - Article
C2 - 37140551
AN - SCOPUS:85156217198
SN - 0309-0167
VL - 83
SP - 348
EP - 356
JO - Histopathology
JF - Histopathology
IS - 3
ER -
