Bioresorbable Drug-Eluting Magnesium-Alloy Scaffold for Treatment of Coronary Artery Disease

CA Campos, Takashi Muramatsu, Iqbal Iqbal, Y Zhang, Yoshinobu Onuma, Hector Garcia Garcia, M Haude, PA Lemos, B Warnack, PWJC (Patrick) Serruys

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Abstract

The introduction of metallic drug-eluting stents has reduced the risk of restenosis and widened the indications of percutaneous coronary intervention in treatment of coronary artery disease. However, this medical device can induce hypersensitive reaction that interferes with the endothelialization and healing process resulting in late persistent or acquired malapposition of the permanent metallic implant. Delayed endotheliaization and malapposition may lead to late and very late stent thrombosis. Bioresorbable scaffolds (BRS) have been introduced to potentially overcome these limitations, as they provide temporary scaffolding and then disappear, liberating the treated vessel from its cage. Magnesium is an essential mineral needed for a variety of physiological functions in the human body and its bioresorbable alloy has the strength-to-weight ratio comparable with that of strong aluminum alloys and alloy steels. The aim of this review is to present the new developments in Magnesium BRS technology, to describe its clinical application and to discuss the future prospects of this innovative therapy.
Original languageUndefined/Unknown
Pages (from-to)24492-24500
Number of pages9
JournalInternational Journal of Molecular Sciences
Volume14
Issue number12
DOIs
Publication statusPublished - 2013

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